Mitoplasticity: Adaptation Biology of the Mitochondrion to the Cellular Redox State in Physiology and Carcinogenesis

Jose, Caroline; Melser, Su; Bénard, Giovanni; Rossignol, Rodrigue

doi:10.1089/ars.2011.4357

Cited by 38 publications

(35 citation statements)

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“…The fact that it is also consistently differentially expressed may indicate that the COI gene, and potentially other mitochondrial genes, may be the original target of selection between the strains (Meiklejohn, Montooth, and Rand 2007). Changes in mitochondrial functions are associated to changes in energy demand or supply (Jose et al 2013). In addition, variations in mitochondrial sequences can be the cause of mitonuclear incompatibilities between species (Hill 2015).…”

Section: Cc-by-nc-ndmentioning

confidence: 99%

Transcriptional differences between the two host strains of Spodoptera frugiperda (Lepidoptera: Noctuidae)

Orsucci

Moné

Audiot

et al. 2018

Preprint

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crops such as corn, sorghum and soybean. While FAW larvae are considered polyphagous, differences in diet preference have been described between two genetic variants: the Corn strain (sf-C) and the Rice strain (sf-R). These two strains are sometimes considered as distinct species, raising the hypothesis that host plant specialization might have driven their divergence. Ecological speciation takes place when adaptations to different ecological niches lead to the reproductive isolation of two populations. Under this hypothesis, we expect that the transcriptional response to the host plants should affect differently the fitness of the two FAW strains. We also expect that these genes should also be linked to a reproductive isolation mechanism between the strains. In this study, we performed controlled reciprocal transplant (RT) experiments to address the impact of plant diet on several traits linked to the fitness of the sf-C and sf-R strains. The phenotypical data suggest that sf-C is specialized to corn. We then used RNA-Seq to analyze the gene expression of FAW larvae from RT experiments. We show that each strain has a different response to the same plant diets. However, we also found constitutive transcriptional differences between strains in laboratory and in natural populations. In particular, we show that mitochondrial transcription is the main difference between strains. A difference in mitochondrial function may be the basis for a shift in host plant and could be involved in hybrid incompatibility, raising the hypothesis that mitochondrial genome is the main target of selection between the two strains.. CC-BY-NC-ND 4.0 International license It is made available under a was not peer-reviewed) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. (Goergen et al. 2016;Jeger et al. 2017).The FAW is a polyphagous species, being documented on over 100 plants from 27 different families (Pogue 2002). However, using allozymes electrophoresis monitoring, a significant genetic heterogeneity has been observed in FAW . CC-BY-NC-ND 4.0 International license It is made available under a was not peer-reviewed) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity.The copyright holder for this preprint (which . http://dx.doi.org/10.1101/263186 doi: bioRxiv preprint first posted online Mar. 5, 2018; 4 populations that was associated with feeding preferences (Pashley et al. 1985;Pashley 1986). One genetic haplotype was mostly found on corn (Zea mais), sorghum (Sorghum spp.) and cotton (Gossypium spp.) and was named the corn strain (sf-C). Another haplotype was found associated to individuals collected on smaller grasses such as turf, pasture (Cynodon dactylon) grasses and rice (Oryza spp.), and has been named the rice strain (sf-R) (Pashley 1988). Subsequent studies have confirmed these genetic differences on markers such as the mitochondrial gene Pashley and Martin 1987;Pashley, Hammond, and Hardy 1992). In order to detect post-zygotic...

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Section: Cc-by-nc-ndmentioning

confidence: 99%

Transcriptional differences between the two host strains of Spodoptera frugiperda (Lepidoptera: Noctuidae)

Orsucci

Moné

Audiot

et al. 2018

Preprint

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“…This may either be the result of increased energy expenditure such as with endurance training, or due to a functional mitochondrial defect or mutation, relevant during pathological conditions. During energy crisis, ATP deficiency and/or mitochondrial dysfunction will activate adaptive mechanisms attempting to counterbalance this situation [23,24,[42][43][44]. These interlinked regulatory systems control mitochondrial content at the transcriptional and functional level by modulating mitochondrial biogenesis/degradation, fission/fusion dynamics, motility and/or respiration [23].…”

Section: Regulation Of Mitochondrial Contentmentioning

confidence: 99%

“…During energy crisis, ATP deficiency and/or mitochondrial dysfunction will activate adaptive mechanisms attempting to counterbalance this situation [23,24,[42][43][44]. These interlinked regulatory systems control mitochondrial content at the transcriptional and functional level by modulating mitochondrial biogenesis/degradation, fission/fusion dynamics, motility and/or respiration [23]. Of note, mitochondrial content modulation might not work identically in the various cell types because of their different biological function and mitochondrial morphology (Fig.…”

Section: Regulation Of Mitochondrial Contentmentioning

confidence: 99%

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Regulation and Quantification of Cellular Mitochondrial Morphology and Content

Tronstad¹,

Nooteboom²,

Nilsson³

et al. 2014

CPD

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Running title: Regulation and quantification of mitochondrial morphology and content. Word count: 15,454 (total)Characters: 107,091 (including spaces); 92,067 (excluding spaces) Keywords: mitochondrial biogenesis, mitochondrial dynamics, mitochondrial degradation, living cells, TMRM, microscopy, segmentation, image analysis.Page 2 of 37 ABSTRACTMitochondria play a key role in signal transduction, redox homeostasis and cell survival, which extends far beyond their classical functioning in ATP production and energy metabolism. In living cells, mitochondrial content ("mitochondrial mass") depends on the cell-controlled balance between mitochondrial biogenesis and degradation. These processes are intricately linked to changes in net mitochondrial morphology and spatiotemporal positioning ("mitochondrial dynamics"), which are governed by mitochondrial fusion, fission and motility. It is becoming increasingly clear that mitochondrial mass and dynamics, as well as its ultrastructure and volume, are mechanistically linked to mitochondrial function and the cell. This means that proper quantification of mitochondrial morphology and content is of prime importance in understanding mitochondrial and cellular physiology in health and disease. This review first presents how cellular mitochondrial content is regulated at the level of mitochondrial biogenesis, degradation and dynamics. Next we discuss how mitochondrial dynamics and content can be analyzed with a special emphasis on quantitative live-cell microscopy strategies.

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“…18 A growing body of evidence indicates that mitochondrial network morphology and function are closely connected in active metabolic cells, particularly in cardiomyocytes. 19 Yu et al 20 showed that hyperglycemia leads to Drp1-induced mitochondrial fission in neonatal rat ventricular myocytes, which in turn induced mitochondrial dysfunction and proapoptotic pathway activation. In agreement, Shenouda et al 21 showed that hyperglycemia alters the expression of proteins implicated in mitochondrial dynamics, that is, increased expression of FIS1 and DRP1 proteins, and induces mitochondrial fragmentation in human endothelial cells.…”

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confidence: 99%

Myocardial Contractile Dysfunction Is Associated With Impaired Mitochondrial Function and Dynamics in Type 2 Diabetic but Not in Obese Patients

et al. 2014

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O besity and type 2 diabetes mellitus (DM) have reached epidemic levels worldwide. These 2 metabolic disorders are independent risk factors for the development of heart failure. [1][2][3] Epidemiological and clinical studies strongly support the existence of obesity and diabetic cardiomyopathies unrelated to coronary artery disease, hypertension, and other comorbidities. 4,5 Clinical Perspective on p 564Studies in rodent models of obesity and DM have identified intrinsic cardiomyocyte dysfunctions secondary to alterations in energy substrate utilization, mitochondrial dysfunction, increased oxidative stress, and intracellular accumulation of lipotoxic byproducts. Similarly, human studies have shown that dysregulation of the energy conversion process is one of the major characteristics of the failing heart of subjects with cardiomyopathy related to DM or obesity. 6,7Background-Obesity and diabetes mellitus are independently associated with the development of heart failure. In this study, we determined the respective effects of obesity, insulin resistance, and diabetes mellitus on the intrinsic contraction and mitochondrial function of the human myocardium before the onset of cardiomyopathy. Methods and Results-Right atrial myocardium was obtained from 141 consecutive patients presenting no sign of cardiomyopathy. We investigated ex vivo isometric contraction, mitochondrial respiration and calcium retention capacity, and respiratory chain complex activities and oxidative stress status. Diabetes mellitus was associated with a pronounced impairment of intrinsic contraction, mitochondrial dysfunction, and increased myocardial oxidative stress, regardless of weight status. In contrast, obesity was associated with less pronounced contractile dysfunction without any significant perturbation of mitochondrial function or oxidative stress status. Tested as continuous variables, glycated hemoglobin A 1C , but neither body mass index nor the insulin resistance index (homeostasis model assessment-insulin resistance), was independently associated with cardiac mitochondrial function. Furthermore, diabetes mellitus was associated with cardiac mitochondrial network fragmentation and significantly decreased expression of the mitochondrial fusion related protein MFN1. Myocardial MFN1 content was inversely proportional to hemoglobin A 1C . Conclusion-Worsening

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Mitoplasticity: Adaptation Biology of the Mitochondrion to the Cellular Redox State in Physiology and Carcinogenesis

Cited by 38 publications

References 283 publications

Transcriptional differences between the two host strains of Spodoptera frugiperda (Lepidoptera: Noctuidae)

Transcriptional differences between the two host strains of Spodoptera frugiperda (Lepidoptera: Noctuidae)

Regulation and Quantification of Cellular Mitochondrial Morphology and Content

Myocardial Contractile Dysfunction Is Associated With Impaired Mitochondrial Function and Dynamics in Type 2 Diabetic but Not in Obese Patients

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