Mitophagy in cancer and cancer stem cells: a role in metabolic reprogramming

Santoshkumar, Anirudh; Ray, Srijit; Narayanan, Samyukta; Kumar, Dhruv; Harihar, Sitaram

doi:10.1016/b978-0-323-99879-6.00009-2

Cited by 2 publications

(4 citation statements)

References 69 publications

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“…Mitophagy is a process of selective removal of old or dysfunctional mitochondria through the autophagic pathway and thus plays a crucial role in mitochondria quality, ROS production, and cellular metabolism. This process plays a critical role in regulating multiple-cellular signaling and processes such as cell growth, metabolic alterations, proliferation, quiescence, and cell death [ 104 ]. Due to the regulation of such crucial functions, mitophagy also plays a key role in the regulation of stem-cell functions.…”

Section: Mitochondrial Autophagy: Mitophagy In Cscsmentioning

confidence: 99%

“…From past evidence, mitophagy has been shown to be required for the self-renewal of CSCs by turning over respiring mitochondria to maintain CSCs in a glycolytic state with low levels of oxidative metabolism [ 121 , 122 ]. The balance between glycolysis and oxidative metabolism has been reported in numerous systems to determine the rates of stem-cell quiescence versus differentiation [ 104 , 116 , 122 ]. In this regard, the upregulation of mitophagy-associated flux mediated by BNIP3L has been reported in human colorectal cancer-derived CSCs [ 123 ].…”

Section: Mitochondrial Autophagy: Mitophagy In Cscsmentioning

confidence: 99%

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Emerging Role of Autophagy in Governing Cellular Dormancy, Metabolic Functions, and Therapeutic Responses of Cancer Stem Cells

Tiwari,

Srivastava,

Abbas

et al. 2024

Cells

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Tumors are composed of heterogeneous populations of dysregulated cells that grow in specialized niches that support their growth and maintain their properties. Tumor heterogeneity and metastasis are among the major hindrances that exist while treating cancer patients, leading to poor clinical outcomes. Although the factors that determine tumor complexity remain largely unknown, several genotypic and phenotypic changes, including DNA mutations and metabolic reprograming provide cancer cells with a survival advantage over host cells and resistance to therapeutics. Furthermore, the presence of a specific population of cells within the tumor mass, commonly known as cancer stem cells (CSCs), is thought to initiate tumor formation, maintenance, resistance, and recurrence. Therefore, these CSCs have been investigated in detail recently as potential targets to treat cancer and prevent recurrence. Understanding the molecular mechanisms involved in CSC proliferation, self-renewal, and dormancy may provide important clues for developing effective therapeutic strategies. Autophagy, a catabolic process, has long been recognized to regulate various physiological and pathological processes. In addition to regulating cancer cells, recent studies have identified a critical role for autophagy in regulating CSC functions. Autophagy is activated under various adverse conditions and promotes cellular maintenance, survival, and even cell death. Thus, it is intriguing to address whether autophagy promotes or inhibits CSC functions and whether autophagy modulation can be used to regulate CSC functions, either alone or in combination. This review describes the roles of autophagy in the regulation of metabolic functions, proliferation and quiescence of CSCs, and its role during therapeutic stress. The review further highlights the autophagy-associated pathways that could be used to regulate CSCs. Overall, the present review will help to rationalize various translational approaches that involve autophagy-mediated modulation of CSCs in controlling cancer progression, metastasis, and recurrence.

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Section: Mitochondrial Autophagy: Mitophagy In Cscsmentioning

confidence: 99%

Section: Mitochondrial Autophagy: Mitophagy In Cscsmentioning

confidence: 99%

Emerging Role of Autophagy in Governing Cellular Dormancy, Metabolic Functions, and Therapeutic Responses of Cancer Stem Cells

Tiwari,

Srivastava,

Abbas

et al. 2024

Cells

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“…Mitophagy-the lysosome-mediated autophagy specific to mitochondria-is a mechanism used in cells to eliminate damaged, old or unneeded mitochondria. [71][72][73] Mitophagy is conserved in mammalian cells, yeast and plant cells, which use different signalling pathways and proteins to accomplish this process. 74 Two pathways of mitophagy have been well characterized in mammalian cells.…”

Section: Mitochondrial Clearance and Mitophagymentioning

confidence: 99%

“…Damaged is a broad term in mitophagy and may include stress, malfunctions in mtDNA and decreased mitochondrial membrane potential (MMP). 73 The signalling pathways of developmental versus damage-induced mitophagy are distinct 76 (Figures 2 and 3).…”

Section: Mitochondrial Clearance and Mitophagymentioning

confidence: 99%

Mitochondrial regulation of erythropoiesis in homeostasis and disease

Menon,

Slavinsky,

Hermine

et al. 2024

Br J Haematol

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SummaryErythroid cells undergo a highly complex maturation process, resulting in dynamic changes that generate red blood cells (RBCs) highly rich in haemoglobin. The end stages of the erythroid cell maturation process primarily include chromatin condensation and nuclear polarization, followed by nuclear expulsion called enucleation and clearance of mitochondria and other organelles to finally generate mature RBCs. While healthy RBCs are devoid of mitochondria, recent evidence suggests that mitochondria are actively implicated in the processes of erythroid cell maturation, erythroblast enucleation and RBC production. However, the extent of mitochondrial participation that occurs during these ultimate steps is not completely understood. This is specifically important since abnormal RBC retention of mitochondria or mitochondrial DNA contributes to the pathophysiology of sickle cell and other disorders. Here we review some of the key findings so far that elucidate the importance of this process in various aspects of erythroid maturation and RBC production under homeostasis and disease conditions.

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Mitophagy in cancer and cancer stem cells: a role in metabolic reprogramming

Cited by 2 publications

References 69 publications

Emerging Role of Autophagy in Governing Cellular Dormancy, Metabolic Functions, and Therapeutic Responses of Cancer Stem Cells

Emerging Role of Autophagy in Governing Cellular Dormancy, Metabolic Functions, and Therapeutic Responses of Cancer Stem Cells

Mitochondrial regulation of erythropoiesis in homeostasis and disease

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