Mitophagy and cGAS–STING crosstalk in neuroinflammation

Zhou, Xiaogang; Wang, Jing; Yu, Lu; Qiao, Gan; Qin, Dalian; Yuen-Kwan Law, Betty; Ren, Fang; Wu, Jianming; Wu, Anguo

doi:10.1016/j.apsb.2024.05.012

Cited by 3 publications

(1 citation statement)

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“… 31 Inappropriate activation of the cGAS–STING triggered by the nuclear DNA, mtDNA, mitochondrial damage and failures in Parkin–mediated mitophagy has been linked to neurodegenerative diseases. 31 , 39 , 40 Aberrant cGAS–STING response contributes to neuroinflammation and promotes degeneration of neuronal cells. 41 In chronic neurodegenerative diseases states, exacerbated cGAS–STING–mediated IFN-I response shapes the glia phenotype and accelerates disease progression.…”

Section: Introductionmentioning

confidence: 99%

Novel Insights into Parkin–Mediated Mitochondrial Dysfunction and “Mito-Inflammation” in α-Synuclein Toxicity. The Role of the cGAS–STING Signalling Pathway

Gąssowska-Dobrowolska,

Olech-Kochańczyk,

Culmsee

et al. 2024

JIR

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Section: Introductionmentioning

confidence: 99%

Novel Insights into Parkin–Mediated Mitochondrial Dysfunction and “Mito-Inflammation” in α-Synuclein Toxicity. The Role of the cGAS–STING Signalling Pathway

Gąssowska-Dobrowolska,

Olech-Kochańczyk,

Culmsee

et al. 2024

JIR

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Targeting Inflammation and Gut Microbiota with Antibacterial Therapy: Implications for Central Nervous System Health

Wei,

Liu,

Qin

et al. 2024

Ageing Research Reviews

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Harnessing Mitophagy for Therapeutic Advances in Aging and Chronic Neurodegenerative Diseases

Ghosh,

Kumar

2024

Neuroglia

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Introduction: Mitophagy, the selective degradation of damaged mitochondria, is essential for maintaining cellular health and function, particularly in high-energy demanding post-mitotic cells like neurons and in microglial cells. Aging results in impaired mitophagy, leading to mitochondrial dysfunction, oxidative stress, the release of damage-associated proteins (DAMPs), and neuroinflammation, which contribute to neurodegenerative diseases such as Alzheimer’s and Parkinson’s. Mitochondrial dysfunction also contributes to the pathophysiology of depression by affecting synaptic plasticity, increasing neuroinflammation, and heightening oxidative stress. Aim: In this review, we summarize the recent developments on mechanisms of mitophagy, its therapeutic role in neuroprotection, and its implications in aging and neuroinflammation, complemented by future research requirements and implications. Result/Discussion: Therapeutic strategies that promote mitochondrial health, including enhancing mitophagy and mitochondrial biogenesis, show promise in treating neurodegenerative diseases and depression. Recent findings have emphasized therapeutic strategies to modulate mitophagy, such as pharmacological agents like urolithin A and rapamycin, genetic interventions such as PINK1/Parkin gene therapy, mitochondrial transplantation, and lifestyle and dietary interventions such as caloric restriction, exercise, and dietary supplements such as resveratrol and CoQ10. Key regulators of mitophagy, including the PINK1/Parkin pathway and various proteins like BNIP3, NIX, and FUNDC1, which facilitate the removal of damaged mitochondria, play a crucial role. Conclusions: These results highlight the importance of understanding the interplay between mitophagy and neuroinflammation and show that modulation of mitophagy can reduce oxidative stress and improve neuroinflammatory outcomes and depression in age-related neurodegenerative diseases. However, despite significant progress, challenges remain in understanding the underlying molecular mechanisms of mitophagy and its therapeutic regulation in aging disorders.

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Mitophagy and cGAS–STING crosstalk in neuroinflammation

Cited by 3 publications

References 311 publications

Novel Insights into Parkin–Mediated Mitochondrial Dysfunction and “Mito-Inflammation” in α-Synuclein Toxicity. The Role of the cGAS–STING Signalling Pathway

Novel Insights into Parkin–Mediated Mitochondrial Dysfunction and “Mito-Inflammation” in α-Synuclein Toxicity. The Role of the cGAS–STING Signalling Pathway

Targeting Inflammation and Gut Microbiota with Antibacterial Therapy: Implications for Central Nervous System Health

Harnessing Mitophagy for Therapeutic Advances in Aging and Chronic Neurodegenerative Diseases

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