Mitomycin-C-loaded Alginate Carriers for Bladder Cancer Chemotherapy: In Vivo Studies

Erogğlu, Muzaffer; Öztürk, Emel; Özdemύr, Nalan; Denkbapi, Emύr Bakύ; Doğan, Işιn; Acar, Abuzer; Güzel, M. S.

doi:10.1177/0883911505051853

Cited by 7 publications

(3 citation statements)

References 15 publications

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“…Degradability is crucial for tissue engineering applications. 39 CICAH exhibits slow degradability and uncontrollable degradation kinetics, 17 mainly due to the instability of the gels in the environment with calcium-chelating compounds in vivo. The intact alginate can hardly be cleared out of the body due to a higher molecular weight than the renal clearance threshold.…”

Section: Discussionmentioning

confidence: 99%

Self-cross-linkable hydrogels composed of partially oxidized alginate and gelatin for myocardial infarction repair

Bai

Fang

Zhang

et al. 2013

Journal of Bioactive and Compatible Polymers

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Calcium cross-linked alginate hydrogel has shown positive results for the treatment of myocardial infarction in both acute and chronic rat models. However, cross-linked alginate hydrogels possess poor mechanical properties, uncontrollable degradation, and poor cell adhesion and infiltration. In this study, covalent cross-linking of partially oxidized alginate and gelatin hydrogel was developed for myocardial infarction treatment, as compared to cross-linked alginate hydrogel and saline. Specifically, the gelation process, mechanical properties, and biodegradation of both crosslinked alginate hydrogel and oxidized alginate and gelatin hydrogel were examined in vitro and in vivo; and a rat myocardial infarction model was developed by injecting hydrogel into hearts, and postinjection, echocardiography was performed at 2, 4, and 6 weeks, respectively. Matrix metalloprotease-2/9 activity was also examined by in situ zymography on frozen slices of the treated hearts. Based on the results, that both hydrogels enhanced scar thickness and attenuated heart remodeling compared with the saline control group and that, compared to cross-linked Downloaded from Bai et al. 127alginate hydrogel, oxidized alginate and gelatin hydrogel exhibited the increased mechanical strength, enhanced angiogenesis, and stronger cell-recruiting capacity. It has also been illustrated that oxidized alginate and gelatin hydrogel-treated hearts have much weaker cardiac remodeling, enhanced extracellular matrix accumulation, and reduced matrix metalloprotease activity than cross-linked alginate hydrogel-treated ones. All results suggest oxidized alginate and gelatin hydrogel may be more suitable for the myocardial infarction treatment.

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Section: Discussionmentioning

confidence: 99%

Self-cross-linkable hydrogels composed of partially oxidized alginate and gelatin for myocardial infarction repair

Bai

Fang

Zhang

et al. 2013

Journal of Bioactive and Compatible Polymers

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“…The mucoadhesive properties of polysaccharide carriers enable the desired attachment to the inner wall of the bladder and provide optimum release rate of the encapsulated agent. As regards in vivo-tested systems, calcium alginate rods containing mitomycin C (2 mm in diameter and 15 mm length in the dry form containing 0.2 mg of the drug) were implanted into the rabbit bladder [ 112 ]. Ultrasonographic observations showed that the alginate implant is retained at the injection site for 1 week, during which the drug is released fairly evenly, and 85% of the cargo drug was released at the end of the week.…”

Section: Reservoir-type Intravesical Delivery Systemsmentioning

confidence: 99%

Local Drug Delivery in Bladder Cancer: Advances of Nano/Micro/Macro-Scale Drug Delivery Systems

Marchenko,

Trushina

2023

Pharmaceutics

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Treatment of bladder cancer remains a critical unmet need and requires advanced approaches, particularly the development of local drug delivery systems. The physiology of the urinary bladder causes the main difficulties in the local treatment of bladder cancer: regular voiding prevents the maintenance of optimal concentration of the instilled drugs, while poor permeability of the urothelium limits the penetration of the drugs into the bladder wall. Therefore, great research efforts have been spent to overcome these hurdles, thereby improving the efficacy of available therapies. The explosive development of nanotechnology, polymer science, and related fields has contributed to the emergence of a number of nanostructured vehicles (nano- and micro-scale) applicable for intravesical drug delivery. Moreover, the engineering approach has facilitated the design of several macro-sized depot systems (centimeter scale) capable of remaining in the bladder for weeks and months. In this article, the main rationales and strategies for improved intravesical delivery are reviewed. Here, we focused on analysis of colloidal nano- and micro-sized drug carriers and indwelling macro-scale devices, which were evaluated for applicability in local therapy for bladder cancer in vivo.

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“…In particular, hydrogel formed in situ, filled with cisplatin and rhenium-188 was tested for regional radiochemotherapy of tumors [72]. Alginate networked by ethyleneglycol diglycidyl ether and calcium chloride, filled with mitomycin C (pharmacotherapeautical agent) is used in chemotherapy after transurethral resection; in vivo studies showed the plausibility of such a system [73].…”

Section: Alginates In Biomedicinementioning

confidence: 99%

Alginates and similar exopolysaccharides in biomedical application and pharmacy: Controled delivery of drugs

Marković¹,

Zarubica²,

Stojkovic³

et al. 2016

Adv techn

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Due to its biocompatibility, biodegradability, hydrophility, technological properties and vast availability, polysaccharides are widely used as natural non-toxic polymers in different branches of industry (food, cosmetic, textile, construction industries). Exopolysaccharides (as dextran, pullulan) have recently taken up a significant position in pharmaceutical industry. Alginate has an irreplaceable role in biomedicine, since its hydrogel form is successfully applied for immobilization of a wide range of enzymes, therapeutics, biochemical agents and different kinds of microorganisms and cells (herbal, animal or human). Alginate microspheres and microcapsules are used for controlled release of biologically active molecules, as well as cell carriers in tissue engineering. Special benefits are brought by the simplicity of configuration of alginate hydrogel, including the possibility of the controlled production of micro-and nanoparticles. Taking into account a very important role of alginates in the form of hydrogel in biomedicine, in this paper a specific attention is paid on the preparation and application of alginate matrices, microspheres and microcapsules that may have essential and unexchangeable usage/application. This paper therefore displays various possibilities of use of polysaccharide matrices for biomolecules, polysaccharide as excipients of pharmaceutical products for oral or local application, and provides a review of the examples of innovative applications.

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Mitomycin-C-loaded Alginate Carriers for Bladder Cancer Chemotherapy: In Vivo Studies

Cited by 7 publications

References 15 publications

Self-cross-linkable hydrogels composed of partially oxidized alginate and gelatin for myocardial infarction repair

Self-cross-linkable hydrogels composed of partially oxidized alginate and gelatin for myocardial infarction repair

Local Drug Delivery in Bladder Cancer: Advances of Nano/Micro/Macro-Scale Drug Delivery Systems

Alginates and similar exopolysaccharides in biomedical application and pharmacy: Controled delivery of drugs

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