Mitomycin C in Sinus Surgery: Preliminary Results in a Rabbit Model

Rahal, Akram; Péloquin, Louis; Ahmarani, Christian

doi:10.2310/7070.2001.20838

Cited by 33 publications

(36 citation statements)

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“…In the present study, in group 1 applied single dose of MMC, unlike other animal studies [16][17][18], although mean antrostomy areas were larger than control side when animals were killed, the difference was not statistically significant (p = 0.287). This may be due to the fact that animals were killed at 8 weeks, not at 3 or 6 weeks as in other studies.…”

Section: Discussioncontrasting

confidence: 81%

“…In addition, no injury was observed in electron microscope examinations. Likewise, Rahal et al [17] and Park et al [18] stated that topical MMC was efficacious in their studies on maxillary sinus ostium.…”

Section: Discussionmentioning

confidence: 97%

“…In sinonasal cavity, it was used at concentrations between 0.04-1.2 mg/ml [17,23]. 0.04 concentration was used at a single study and was shown to be inefficient [17]. In the same study, it was also shown that 1 mg/ml concentration provided ostium patency for a period longer than 0.4 mg/ml concentration and at 1 mg/ml concentration temporary impairment in clearance was observed.…”

Section: Discussionmentioning

confidence: 99%

“…It was demonstrated that 0.4 mg/ml MMC exerted antiproliferative effects in fibroblast culture and that at higher doses it led to cell death [15]. In sinonasal cavity, it was used at concentrations between 0.04-1.2 mg/ml [17,23]. 0.04 concentration was used at a single study and was shown to be inefficient [17].…”

Section: Discussionmentioning

confidence: 99%

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The effects of repetitious topical use of mitomycin C on antrostomy patency in maxillary antrostomy created rabbit model

Kavuzlu

Arslan

Taştan

et al. 2011

Eur Arch Otorhinolaryngol

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The aim of our study was to investigate the effect of the topical use of mitomycin C (MMC) intraoperatively in single dose and intra-postoperatively in two doses on the narrowing of antrostomy in maxillary rabbit sinus antrostomies created experimentally. And also to determine the local and systemic side effects of topical MMC. With this objective, 0.6 mg/ml MMC was used to the first group at single dose and to the second group intraoperatively and on third day postoperatively in two doses topically for 5 min. After 8 weeks, although the mean area of antrostomy was larger than that in the control side in the first group, which received single dose MMC, the difference was not statistically significant (p = 0.287). The second group received two doses, and the antrostomy areas were found to be significantly larger than the controls (p = 0.05). Overall, the sides that received MMC were significantly larger (p = 0.029). From the point of histopathological examination of the tissue, it was seen that two-dose MMC increased the edema indicating inflammation and antrostomy resolved with normal respiratory tract epithelium. It was shown by measuring the blood values that nephrotoxic and myelosupressant effect of MMC occurring in systemic use did not occur with single or double dose topical use. Our results demonstrate that even if the number of cases was low, two doses of topical MMC usage prevent the narrowing of antrostomy while single dose MMC does not. And two-dose topical MMC usage does not have local and systemic side effects.

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Section: Discussioncontrasting

confidence: 81%

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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The effects of repetitious topical use of mitomycin C on antrostomy patency in maxillary antrostomy created rabbit model

Kavuzlu

Arslan

Taştan

et al. 2011

Eur Arch Otorhinolaryngol

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“…In topical use, this drug has been used in ophthalmology, otology and laryngology without systemic toxicity, thus being considered safe. It does not cause bleeding, necrosis or infection when used in external acriocistorhinostomy or permanent eyelash lesions in concentrations of up to 1mg/ml 16,18,[20][21][22][23][24][25][26][27] . This study aims at assessing MMC action, in vivo, in patients with eosinophilic NSP through IL5 and GM-CSF analysis, pre and 24hs post application, using RT-PCR (reverse transcription in polymerase chain reaction).…”

Section: Introductionmentioning

confidence: 99%

Efeito da mitomicina C em polipose nasossinusal eosinofílica, in vivo: dosagem de IL5 e GM-CSF, RT-PCR

Assunção

Castro²,

Araújo³

et al. 2006

Rev. Bras. Otorrinolaringol.

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Eosi nophilic nasosinusal polyposis is a chronic inflammatory infection with elevated infiltration of eosinophils, which presents high rate of recurrence after surgical treatment. The continuous inflammatory process that leads to the formation of polyps requires constant clinical treatment. Contributing to the maintenance of eosinophilia are cytokines IL5 (interleukin-5) and GM-CSF (granulocyte macrophages colony-stimulating factor), which show up in elevated concentrations. These oligoproteins diminish the rate of apoptosis and prolong the survival of eosinophils. Aim: By diminishing these cytokines, the action of Mitomycin C (MMC), an antineoplasic drug which inhibits the synthesis of DNA, was studied. In a recent study the power of this drug to cause apoptosis in eosinophils, in vitro, of nasal polyps was verified. Methodology: A biopsy of the nasal polyps was undertaken in 15 patients carriers of eosinophilic nasosinusal polyposis 24 hours after applying 0.5 mg/ml of MMC during five minutes. RT-PCR (reverse transcription of polymerase chain reaction) for IL5 and GM-CSF was the method used to obtain the results. Results: The comparison of the results of GM-CSF pre-and post-application of MMC, when the paired T-test was used, showed p=0.041 and for IL5 we found p<0.001. Conclusion: Topic use of MMC in patients with eosinophilic nasosinusal polyposis shows statistically significant reduction for GM-CSF and significant and important reduction for IL5.

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Endonasal Dacryocystorhinostomy

Goldberg¹

2004

Arch Ophthalmol

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Mitomycin C in Sinus Surgery: Preliminary Results in a Rabbit Model

Cited by 33 publications

References 0 publications

The effects of repetitious topical use of mitomycin C on antrostomy patency in maxillary antrostomy created rabbit model

The effects of repetitious topical use of mitomycin C on antrostomy patency in maxillary antrostomy created rabbit model

Efeito da mitomicina C em polipose nasossinusal eosinofílica, in vivo: dosagem de IL5 e GM-CSF, RT-PCR

Endonasal Dacryocystorhinostomy

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