Mitomycin C extravasation ulcers

Khanna, Anuradha; Asthana, Anjana; Misra, Mahendra K.

doi:10.1002/jso.2930280207

Cited by 14 publications

(2 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This theory, in addition to impaired wound healing (due to DNA insult), may explain why extravasation injuries often persist for a prolonged period of time. 6 Another theory regarding the mechanism behind anthracycline-and mitomycin C-induced tissue injury is generation of semiquinone free radicals. These radicals are further oxidized to form superanion and hydroxyl radicals and peroxides that damage cell membranes, leading to soft tissue injury.…”

Section: Discussionmentioning

confidence: 99%

Distant and Delayed Mitomycin C Extravasation

Patel

Krusa

1999

Pharmacotherapy

View full text Add to dashboard Cite

Mitomycin C is a vesicant chemotherapeutic agent used to treat solid tumors. Its ability to cause delayed and remote tissue injury after intravenous administration is reported in the literature. Two cases of delayed and distant mitomycin C extravasation injury occurred in our institution. In both patients, no evidence of acute extravasation was visible during or immediately after administration. Within 48 hours, one patient reported erythema, burning, and pain in the hand contralateral to the administration site. The second patient developed three distinct ulcerated lesions on her forearm within 6 weeks of receiving the agent. The lesions, located at sites of venipunctures, occurred 12-15 cm proximal to the site of mitomycin infusion. Because the drug has the potential to cause such unusual and unanticipated tissue injuries, health care professionals and patients should be aware of this hazard.

show abstract

Section: Discussionmentioning

confidence: 99%

Distant and Delayed Mitomycin C Extravasation

Patel

Krusa

1999

Pharmacotherapy

View full text Add to dashboard Cite

show abstract

“…MMC is locally highly toxic and extravasation of MMC during i.v. administration may result in severe ulcers with tissue necrosis [113]. Animal experiments have demonstrated teratogenic and oncogenic effects of MMC [104].…”

Section: Chemotherapeutic Agents Used In Picmentioning

confidence: 99%