Mitomycin-C Concentration in Cornea and Aqueous Humor and Apoptosis in the Stroma After Topical Mitomycin-C Application

Abstract

Reducing the applied concentration or decreasing the exposure time might be a good modality for reducing the potential MMC toxicity. The applied MMC concentration had greater effects on the aqueous MMC concentration and apoptosis in the stromal cells than the exposure time.

Corneal endothelium after refractive surgery

“…[65][66][67] However, laboratory evidence of MMC detected in the aqueous humor has led to a concern about endothelial toxicity. [68][69][70] Clinical studies of PRK and the effect of MMC on the endothelium do not show a significant decrease in ECD or a change in cell morphology. 67,[71][72][73][74][75][76][77] Two studies report endothelial cell loss in conjunction with MMC use.…”

Lipid corneal degeneration after trabeculectomy with mitomicin 0.02%

“…The inhibition of keratocyte proliferation observed after photorefractive keratectomy was originally believed to be the main mechanism of MMC, since it was reported to have an antiproliferative effect on cultured human keratocytes. However, since they reported MMC cause apoptosis of cultured human keratocytes, this is now considered its main effect on corneal cells (10) . Corneal NV occurs as a sequel resulting from various causes such as infections, allergies, toxins, anoxia and immune response.…”

Focal Corneal Decompensation After Filtering Surgery With Mitomycin C

“…Some retrospective studies suggested that 0.02% MMC applied for 2 minutes may be as effective as higher doses but may be associated with fewer complications. [12][13][14][15][16] A variety of sponges have been advocated as vehicles for MMC, including Meroce1 and various microsurgical sponges, and it may be possible that manipulating the size or shape of the sponge can influence the effect of the MMC. 16 One study suggested that placing the sponge beneath the scleral flap rather than over intact episclera may improve the success rate without increasing complications.…”