Mitolnc controls cardiac BCAA metabolism and heart hypertrophy by allosteric activation of BCKDH
Maria Weiss,
Sara Hettrich,
Theresa Hofmann
et al.
Abstract:Enzyme activity is determined by various different mechanisms, including posttranslational modifications and allosteric regulation. Allosteric activators are often metabolites but other molecules serve similar functions. So far, examples of long non-coding RNAs (lncRNAs) acting as allosteric activators of enzyme activity are missing. Here, we describe the function of mitolnc in cardiomyocytes, a nuclear encoded long non-coding RNA, located in mitochondria and directly interacting with the branched-chain ketoac… Show more
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