Mitogen-activated protein kinase action in plant response to high-temperature stress: a mini review

Mo, Shuangrong; Qian, Ying; Zhang, Wenjuan; Lü, Qian; Wang, Yan; Ge, Cailin; Ding, Haidong

doi:10.1007/s00709-020-01603-z

Cited by 20 publications

(11 citation statements)

References 31 publications

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“…MAPKs play important roles in regulating responses to abiotic stress. They have been linked to oxidative stress tolerance under heat stress in wheat (47) and are involved in the heat stress response in Arabidopsis , maize and rice (48). The novelty of this gene and the presence-absence variation between Ae.…”

Section: Discussionmentioning

confidence: 99%

Exotic alleles contribute to heat tolerance in wheat under field conditions

Molero

Coombes

Joynson

et al. 2022

Preprint

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Global warming is one of the most significant threats to food security. With temperatures predicted to rise and extreme weather events becoming more common we must safeguard food production by developing crop varieties that are more tolerant to heat stress without compromising yield under favourable conditions. By evaluating 149 spring wheat lines in the field under yield potential and heat stressed conditions, we demonstrate how strategic integration of exotic material significantly increases yield under heat stress compared to elite lines, with no significant yield penalty under favourable conditions. Genome-wide association analysis revealed three marker trait associations, which together increase yield under heat stress by over 50% compared to lines without the advantageous alleles and was associated with approximately 2°C lower canopy temperature. We identified an Aegilops tauschii introgression underlying the most significant of these associations. By comparing overlapping recombination of this introgressed segment between lines, we identified a 1.49Mbp region of the introgression responsible for this association that increases yield under heat stress by 32.4%. The genes within this region were extracted from diverse Ae. tauschii genomes, revealing a novel Ae. tauschii MAPK gene, a SOC1 orthologue and a pair of type-B two-component response regulators. Incorporating these exotic alleles into breeding programmes could serve as a pre-emptive strategy to produce high yielding wheat cultivars that are resilient to the effects of future climate uncertainty with no yield penalty under favourable conditions.

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Section: Discussionmentioning

confidence: 99%

Exotic alleles contribute to heat tolerance in wheat under field conditions

Molero

Coombes

Joynson

et al. 2022

Preprint

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“…MAPK is typically activated by epidermal growth factors, inflammatory factors and growth factors, which has been found to regulate the stress response, inflammatory response, cell proliferation and development (31,32). Results of a previous study demonstrated that MAPK7 deficiency alleviated DNA damage in mouse thymus cells and inhibited the growth of mouse thymus lymphoma (33).…”

Section: Discussionmentioning

confidence: 99%

Pitavastatin maintains MAPK7 expression and alleviates angiotensin II‑induced vascular endothelial cell inflammation and injury

Liu

2021

Exp Ther Med

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Statins have been reported to suppress vascular remodeling in rats with spontaneous hypertension. However, the possible effects of the statin pitavastatin on hypertension-induced endothelial inflammation and injury remain to be fully elucidated. The present study aimed to evaluate the effects of pitavastatin on HUVEC injury and inflammation. HUVECs were exposed to angiotensin (Ang) II with or without pitavastatin co-treatment, after which MAPK7 expression was detected via reverse transcription-quantitative PCR and western blotting. MAPK7 expression was additionally silenced in HUVECs via transfection with short hairpin RNA, followed by Ang II treatment with or without pitavastatin. Cell viability, inflammation, reactive oxygen species (ROS) production, nitric oxide (NO) production and cell apoptosis were then measured by using Cell Conting Kit-8, ELISA, commercial corresponding kits and TUNEL staining, respectively. Western blotting was also used to determine the protein expression of endothelial NO synthase and endothelin 1, and the proteins involved in apoptosis. Results of the present study demonstrated that the expression levels of MAPK7 in Ang II-induced endothelial cells were decreased, which was reversed following treatment with pitavastatin. Pitavastatin reversed the Ang II-induced reduction in cell viability and reversed the Ang II-induced increase in inflammatory factor and ROS levels and apoptosis in HUVECs by activating MAPK7. Treatment with pitavastatin also increased the production of NO in addition to increasing the expression of endothelial NO synthase and endothelin-1 in Ang II-induced HUVECs through MAPK7 activation. Collectively, results from the present study demonstrated that treatment with pitavastatin preserves MAPK7 expression to alleviate Ang II-induced vascular endothelial cell inflammation and injury. Therefore, findings of the present study may help to elucidate the mechanisms underlying the effects of pitavastatin on vascular endothelial cell inflammation and injury.

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“…Additionally, three DEGs involved in the MAPK signal pathway (HAI1, MAPKKK18, and MKK5) were down-regulated in SlCML39 overexpression plants. MAPK cascade is involved in response to HT stress [26,39]. ROS-induced redox signal acts as an important regulator of various stress responses [40].…”

Section: Slcml39 Negatively Regulates Stress/aba-responsive Genes Under Ht Stressmentioning

confidence: 99%

Characteristics of SlCML39, a Tomato Calmodulin-like Gene, and Its Negative Role in High Temperature Tolerance of Arabidopsis thaliana during Germination and Seedling Growth

Ding

Qian

Fang

et al. 2021

IJMS

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Calmodulin-like (CML) proteins are primary calcium sensors and function in plant growth and response to stress stimuli. However, so far, the function of plant CML proteins, including tomato, is still unclear. Previously, it was found that a tomato (Solanum lycopersicum) CML, here named SlCML39, was significantly induced by high temperature (HT) at transcription level, but its biological function is scarce. In this study, the characteristics of SlCML39 and its role in HT tolerance were studied. SlCML39 encodes a protein of 201 amino acids containing four EF hand motifs. Many cis-acting elements related to plant stress and hormone response appear in the promoter regions of SlCML39. SlCML39 is mainly expressed in the root, stem, and leaf and can be regulated by HT, cold, drought, and salt stresses as well as ABA and H2O2. Furthermore, heterologous overexpression of SlCML39 reduces HT tolerance in Arabidopsis thaliana at the germination and seedling growth stages. To better understand the molecular mechanism of SlCML39, the downstream gene network regulated by SlCML39 under HT was analyzed by RNA-Seq. Interestingly, we found that many genes involved in stress responses as well as ABA signal pathway are down-regulated in the transgenic seedlings under HT stress, such as KIN1, RD29B, RD26, and MAP3K18. Collectively, these data indicate that SlCML39 acts as an important negative regulator in response to HT stress, which might be mediated by the ABA signal pathway.

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Mitogen-activated protein kinase action in plant response to high-temperature stress: a mini review

Cited by 20 publications

References 31 publications

Exotic alleles contribute to heat tolerance in wheat under field conditions

Exotic alleles contribute to heat tolerance in wheat under field conditions

Pitavastatin maintains MAPK7 expression and alleviates angiotensin II‑induced vascular endothelial cell inflammation and injury

Characteristics of SlCML39, a Tomato Calmodulin-like Gene, and Its Negative Role in High Temperature Tolerance of Arabidopsis thaliana during Germination and Seedling Growth

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