Mitochondrion: Main organelle in orchestrating cancer escape from chemotherapy
Samaneh Mostafavi,
Nahid Eskandari
Abstract:BackgroundChemoresistance is a challenging barrier to cancer therapy, and in this context, the role of mitochondria is significant. We put emphasis on key biological characteristics of mitochondria, contributing to tumor escape from various therapies, to find the “Achilles' Heel” of cancer cells for future drug design.Recent findingsThe mitochondrion is a dynamic organelle, and its existence is important for tumor growth. Its metabolites also cooperate with cell signaling in tumor proliferation and drug resist… Show more
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