Mitochondrially Localized MPZL3 Functions as a Negative Regulator of Sebaceous Gland Size and Sebocyte Proliferation

Wikramanayake, Tongyu C.; Nicu, Carina; Gherardini, Jennifer; Mello, Anna C G C V; Chéret, Jérémy; Paus, Ralf

doi:10.1016/j.jid.2021.12.037

Cited by 2 publications

(2 citation statements)

References 48 publications

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“…Sebaceous glands are typically found in association with hair follicles, and their structure consists of a single duct that opens into the hair follicle, with a cluster of secretory cells at the base of the duct. The glandular cells are primarily composed of sebocytes, which are specialized cells that produce and accumulate lipids and other substances that make up the sebum ( Lovászi et al, 2017 ; Wikramanayake et al, 2022 ). Given the high metabolic activity of sebocytes dedicated to the synthesis of lipids of the sebum, the cytoplasm of these cells is rich in highly active mitochondria ( Schneider and Paus, 2010 ).…”

Section: Mitochondria Alterations In Different Cell Types During Agingmentioning

confidence: 99%

“…This lowers the level of surface lipids and causes skin xerosis, a common condition found in elderly persons. A recent study has demonstrated that myelin protein zero-like 3, an Ig-like v-type mitochondrially localized nucleus-encoded protein that regulates lipid metabolism, energy expenditure, and the differentiation and function of epidermal keratinocytes, acts as a negative regulator of sebaceous gland size and proliferation ( Wikramanayake et al, 2022 ). Although the relationship between myelin protein zero-like 3 and age-related changes in sebaceous glands has not been established, this mitochondrial protein may participate in regulating physiological parameters of sebocytes during aging.…”

Section: Mitochondria Alterations In Different Cell Types During Agingmentioning

confidence: 99%

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Mitochondrial dynamics and metabolism across skin cells: implications for skin homeostasis and aging

Martic,

Papaccio,

Bellei

et al. 2023

Front. Physiol.

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Aging of human skin is a complex process leading to a decline in homeostasis and regenerative potential of this tissue. Mitochondria are important cell organelles that have a crucial role in several cellular mechanisms such as energy production and free radical maintenance. However, mitochondrial metabolism as well as processes of mitochondrial dynamics, biogenesis, and degradation varies considerably among the different types of cells that populate the skin. Disturbed mitochondrial function is known to promote aging and inflammation of the skin, leading to impairment of physiological skin function and the onset of skin pathologies. In this review, we discuss the essential role of mitochondria in different skin cell types and how impairment of mitochondrial morphology, physiology, and metabolism in each of these cellular compartments of the skin contributes to the process of skin aging.

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Section: Mitochondria Alterations In Different Cell Types During Agingmentioning

confidence: 99%

Section: Mitochondria Alterations In Different Cell Types During Agingmentioning

confidence: 99%

Mitochondrial dynamics and metabolism across skin cells: implications for skin homeostasis and aging

Martic,

Papaccio,

Bellei

et al. 2023

Front. Physiol.

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Targeting mitochondria in dermatological therapy: beyond oxidative damage and skin aging

Wikramanayake

Chéret

Sevilla

et al. 2022

Expert Opinion on Therapeutic Targets

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Introduction:The analysis of the role of the mitochondria in oxidative damage and skin aging is a significant aspect of dermatological research. Mitochondria generate most reactive oxygen species (ROS); however, excessive ROS are cytotoxic and DNA-damaging and promote (photo-)aging. ROS also possesses key physiological and regulatory functions and mitochondrial dysfunction is prominent in several skin diseases including skin cancers. Although many standard dermatotherapeutics modulate mitochondrial function, dermatological therapy rarely targets the mitochondria. Accordingly, there is a rationale for "mitochondrial dermatology"-based approaches to be applied to therapeutic research.Areas covered: This paper examines the functions of mitochondria in cutaneous physiology beyond energy (ATP) and ROS production. Keratinocyte differentiation and epidermal barrier maintenance, appendage morphogenesis and homeostasis, photoaging and skin cancer are considered. Based on related PubMed search results, the paper evaluates thyroid hormones, glucocorticoids, Vitamin D3 derivatives, retinoids, cannabinoid receptor agonists, PPARγ agonists, thyrotropin, and thyrotropinreleasing hormone as instructive lead compounds. Moreover, the mitochondrial protein MPZL3 as a promising new drug target for future "mitochondrial dermatology" is highlighted.Expert opinion: Future dermatological therapeutic research should have a mitochondrial medicine emphasis. Focusing on selected lead agents, protein targets, in silico drug design, and model diseases will fertilize a mito-centric approach.

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Mitochondrially Localized MPZL3 Functions as a Negative Regulator of Sebaceous Gland Size and Sebocyte Proliferation

Cited by 2 publications

References 48 publications

Mitochondrial dynamics and metabolism across skin cells: implications for skin homeostasis and aging

Mitochondrial dynamics and metabolism across skin cells: implications for skin homeostasis and aging

Targeting mitochondria in dermatological therapy: beyond oxidative damage and skin aging

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