Mitochondrial transfer in PC-3 cells fingerprinted in ferroptosis sensitivity: a brand new approach targeting cancer metabolism

Nikoo, Amirsadegh; Roudkenar, Mehryar Habibi; Sato, Tomoaki; Kuwahara, Yoshikazu; Tomita, Kazuo; Pourmohammadi-Bejarpasi, Zahra; Najafi-Ghalehlou, Nima; Roushandeh, Amaneh Mohammadi

doi:10.1007/s13577-023-00896-5

Cited by 1 publication

(2 citation statements)

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“…In addition, one study demonstrated that stem cells donate their mitochondria to neighboring cells, aiding oxidative stress resistance and improving metabolic conditions, and thus promoting cell proliferation and enhancing antiapoptotic capability [42]. For instance, the introduction of healthy mitochondria into human prostate cancer PC-3 cells promoted cell proliferation and rescued cells from cisplatin-induced death [23]. Moreover, the engulfment of foreign somatic-derived mitochondria by MSCs increased the expression of the cytoprotective enzyme HO-1 and stimulated mitochondrial biogenesis [42].…”

Section: Discussionmentioning

confidence: 99%

“…MSCs donate their healthy mitochondria to damaged cells, thereby enhancing the recipient cells' oxidative stress resistance, proliferation, and antiapoptotic capability [21]. In addition, such intercellular mitochondrial transfer is involved in the regulation of cancer progression [21][22][23][24]. Nevertheless, the mechanisms through which endothelial mitochondria affect melanoma progression, and subsequently regulate TAMs to promote tumor growth after their transfer, remain to be elucidated.…”

Section: Introductionmentioning

confidence: 99%

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Endothelial Mitochondria Transfer to Melanoma Induces M2-Type Macrophage Polarization and Promotes Tumor Growth by the Nrf2/HO-1-Mediated Pathway

Kuo,

Tsai,

Cheng

et al. 2024

IJMS

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Gynecologic tract melanoma is a malignant tumor with poor prognosis. Because of the low survival rate and the lack of a standard treatment protocol related to this condition, the investigation of the mechanisms underlying melanoma progression is crucial to achieve advancements in the relevant gynecological surgery and treatment. Mitochondrial transfer between adjacent cells in the tumor microenvironment regulates tumor progression. This study investigated the effects of endothelial mitochondria on the growth of melanoma cells and the activation of specific signal transduction pathways following mitochondrial transplantation. Mitochondria were isolated from endothelial cells (ECs) and transplanted into B16F10 melanoma cells, resulting in the upregulation of proteins associated with tumor growth. Furthermore, enhanced antioxidation and mitochondrial homeostasis mediated by the Sirt1-PGC-1α-Nrf2-HO-1 pathway were observed, along with the inhibition of apoptotic protein caspase-3. Finally, the transplantation of endothelial mitochondria into B16F10 cells promoted tumor growth and increased M2-type macrophages through Nrf2/HO-1-mediated pathways in a xenograft animal model. In summary, the introduction of exogenous mitochondria from ECs into melanoma cells promoted tumor growth, indicating the role of mitochondrial transfer by stromal cells in modulating a tumor’s phenotype. These results provide valuable insights into the role of mitochondrial transfer and provide potential targets for gynecological melanoma treatment.

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Section: Discussionmentioning

confidence: 99%