Mitochondrial Transfer as a Novel Therapeutic Approach in Disease Diagnosis and Treatment

Clemente-Suárez, Vicente Javier; Martín-Rodríguez, Alexandra; Yáñez-Sepúlveda, Rodrigo; Tornero-Aguilera, José Francisco

doi:10.3390/ijms24108848

Cited by 26 publications

(19 citation statements)

References 209 publications

(301 reference statements)

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“…M-sec also serves as a therapeutic target. Inhibiting M-sec blocks the formation of TNTs [ 105 ]. Due to the lack of specific TNT markers, the inhibitors mentioned earlier, including L-778,123 and cytochalasins, only partially prohibit the formation of TNTs and have limited ability to inhibit tumor growth [ 83 ].…”

Section: Clinical Application Of Mitochondrial Transplantationmentioning

confidence: 99%

Mitochondrial transfer in tunneling nanotubes—a new target for cancer therapy

Guan,

Wu,

Zhou

et al. 2024

J Exp Clin Cancer Res

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A century ago, the Warburg effect was first proposed, revealing that cancer cells predominantly rely on glycolysis during the process of tumorigenesis, even in the presence of abundant oxygen, shifting the main pathway of energy metabolism from the tricarboxylic acid cycle to aerobic glycolysis. Recent studies have unveiled the dynamic transfer of mitochondria within the tumor microenvironment, not only between tumor cells but also between tumor cells and stromal cells, immune cells, and others. In this review, we explore the pathways and mechanisms of mitochondrial transfer within the tumor microenvironment, as well as how these transfer activities promote tumor aggressiveness, chemotherapy resistance, and immune evasion. Further, we discuss the research progress and potential clinical significance targeting these phenomena. We also highlight the therapeutic potential of targeting intercellular mitochondrial transfer as a future anti-cancer strategy and enhancing cell-mediated immunotherapy. Graphical Abstract

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Section: Clinical Application Of Mitochondrial Transplantationmentioning

confidence: 99%

Mitochondrial transfer in tunneling nanotubes—a new target for cancer therapy

Guan,

Wu,

Zhou

et al. 2024

J Exp Clin Cancer Res

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“…Pretreatment and treatment of EAE mice with MitoQ reduces axonal loss and decreases neurological deficits associated with EAE, suggesting that MitoQ has a realized neuroprotective effect ( Mao et al, 2013 ). Mitochondrial transplantation in animal models of MS has recently emerged as a potential therapeutic approach to restore mitochondrial function in diseased cells ( Clemente-Suárez et al, 2023 ). However, methods involving the use of mitochondrial transplants to slow or block axonal degeneration require additional in vitro or in vivo studies for validation ( Picone and Nuzzo, 2022 ).…”

Section: Treatment Strategies and Future Prospectsmentioning

confidence: 99%

The role of the “gut microbiota-mitochondria” crosstalk in the pathogenesis of multiple sclerosis

Tian,

Huang,

Wang

et al. 2024

Front. Microbiol.

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Multiple Sclerosis (MS) is a neurologic autoimmune disease whose exact pathophysiologic mechanisms remain to be elucidated. Recent studies have shown that the onset and progression of MS are associated with dysbiosis of the gut microbiota. Similarly, a large body of evidence suggests that mitochondrial dysfunction may also have a significant impact on the development of MS. Endosymbiotic theory has found that human mitochondria are microbial in origin and share similar biological characteristics with the gut microbiota. Therefore, gut microbiota and mitochondrial function crosstalk are relevant in the development of MS. However, the relationship between gut microbiota and mitochondrial function in the development of MS is not fully understood. Therefore, by synthesizing previous relevant literature, this paper focuses on the changes in gut microbiota and metabolite composition in the development of MS and the possible mechanisms of the crosstalk between gut microbiota and mitochondrial function in the progression of MS, to provide new therapeutic approaches for the prevention or reduction of MS based on this crosstalk.

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“…These investigators showed a similar improvement in doxorubicin-induced toxicity in cultured cardiomyocytes ( 96 ). Thus, transfer of healthy intact mitochondria within EVs represents a novel and potentially viable therapy for patients with mitochondrial damage or dysfunction ( 97 , 98 ).…”

Section: Mitochondrial Autoimmunity and Myocarditismentioning

confidence: 99%

Mitochondrial extracellular vesicles, autoimmunity and myocarditis

Di Florio,

Beetler,

McCabe

et al. 2024

Front. Immunol.

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For many decades viral infections have been suspected as ‘triggers’ of autoimmune disease, but mechanisms for how this could occur have been difficult to establish. Recent studies have shown that viral infections that are commonly associated with viral myocarditis and other autoimmune diseases such as coxsackievirus B3 (CVB3) and SARS-CoV-2 target mitochondria and are released from cells in mitochondrial vesicles that are able to activate the innate immune response. Studies have shown that Toll-like receptor (TLR)4 and the inflammasome pathway are activated by mitochondrial components. Autoreactivity against cardiac myosin and heart-specific immune responses that occur after infection with viruses where the heart is not the primary site of infection (e.g., CVB3, SARS-CoV-2) may occur because the heart has the highest density of mitochondria in the body. Evidence exists for autoantibodies against mitochondrial antigens in patients with myocarditis and dilated cardiomyopathy. Defects in tolerance mechanisms like autoimmune regulator gene (AIRE) may further increase the likelihood of autoreactivity against mitochondrial antigens leading to autoimmune disease. The focus of this review is to summarize current literature regarding the role of viral infection in the production of extracellular vesicles containing mitochondria and virus and the development of myocarditis.

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Mitochondrial Transfer as a Novel Therapeutic Approach in Disease Diagnosis and Treatment

Cited by 26 publications

References 209 publications

Mitochondrial transfer in tunneling nanotubes—a new target for cancer therapy

Mitochondrial transfer in tunneling nanotubes—a new target for cancer therapy

The role of the “gut microbiota-mitochondria” crosstalk in the pathogenesis of multiple sclerosis

Mitochondrial extracellular vesicles, autoimmunity and myocarditis

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