Mitochondrial-targeted nanoparticles: Delivery and therapeutic agents in cancer

Ganji, Chaithaithanya; Muppala, Veda; Khan, Musaab; Farran, Batoul

doi:10.1016/j.drudis.2022.103469

Cited by 18 publications

(13 citation statements)

References 118 publications

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“…With modern tools and strategies, it will be possible to design a more efficient mitochondrial targeting system that will support synergistic approaches as well as guided diagnostic imaging. These strategies might further give directions for development of theranostic nanotechnology capable of targeting other cell organelles, which would exemplify a landmark in cancer therapy. ,, …”

Section: Discussionmentioning

confidence: 99%

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Photodynamic Therapy Induced Mitochondrial Targeting Strategies for Cancer Treatment: Emerging Trends and Insights

Desai,

Choudhary,

Chowdhury

et al. 2024

Mol. Pharmaceutics

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The perpetuity of cancer prevalence at a global level calls for development of novel therapeutic approaches with improved targetability and reduced adverse effects. Conventional cancer treatments have a multitude of limitations such as nonselectivity, invasive nature, and severe adverse effects. Chemotherapy is also losing its efficacy because of the development of multidrug resistance in the majority of cancers. To address these issues, selective targeting-based approaches are being explored for an effective cancer treatment. Mitochondria, being the moderator of a majority of crucial cellular pathways like metabolism, apoptosis, and reactive oxygen species (ROS) homeostasis, are an effective targeting site. Mitochondria-targeted photodynamic therapy (PDT) has arisen as a potential approach in this endeavor. By designing photosensitizers (PSs) that preferentially accumulate in the mitochondria, PDT offers a localized technique to induce cytotoxicity in cancer cells. In this review, we intend to explore the crucial principles and challenges associated with mitochondria-targeted PDT, including variability in mitochondrial function, mitochondria-specific PSs, targeted nanocarrier-based monotherapy, and combination therapies. The hurdles faced by this emerging strategy with respect to safety, optimization, clinical translation, and scalability are also discussed. Nonetheless, mitochondria-targeted PDT exhibits a significant capacity in cancer treatment, especially in combination with other therapeutic modalities. With perpetual research and technological advancements, this treatment strategy is a great addition to the arsenal of cancer treatment options, providing better tumor targetability while reducing the damage to surrounding healthy tissues. This review emphasizes the current status of mitochondria-targeted PDT, limitations, and future prospects in its pursuit of safe and efficacious cancer therapy.

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Section: Discussionmentioning

confidence: 99%

“…These strategies might further give directions for development of theranostic nanotechnology capable of targeting other cell organelles, which would exemplify a landmark in cancer therapy. 38,40,91 ■ ASSOCIATED CONTENT…”

Section: Targeting With Pdtmentioning

confidence: 99%

Photodynamic Therapy Induced Mitochondrial Targeting Strategies for Cancer Treatment: Emerging Trends and Insights

Desai,

Choudhary,

Chowdhury

et al. 2024

Mol. Pharmaceutics

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“…The molecules of TiO 2 NPs would go into an excited state upon absorbing a photon with energy above or equal to the gap energy, and created negative electrons (e-) in the conduction, leaving a positive charged hole (h+) ( George et al, 2011 ). This allowed them to induce reactive oxygen species (ROS), which was the key factor used by the researchers to kill cancer cells in other cancer therapy studies ( Ganji et al, 2022 ).…”

Section: Discussionmentioning

confidence: 99%

Glutamine coated titanium for synergistic sonodynamic and photothermal on tumor therapy upon targeted delivery

Zhang

Zhu

Wan

et al. 2023

Front. Bioeng. Biotechnol.

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Introduction: The application of titanium dioxide nanoparticles (TiO2 NPs) for cancer therapy has been studied for decades; however, the targeted delivery of TiO2 NPs to tumor tissues is challenging, and its efficiency needs to be improved.Method: In this study, we designed an oxygen-deficient TiO2-x coated with glutamine layer for targeted delivery, as well as the enhanced separation of electrons (e-) and holes (h+) following the joint application of sonodynamic therapy (SDT) and photothermal therapy (PTT).Results: This oxygen-deficient TiO2-x possesses relatively high photothermal and sonodynamic efficiency at the 1064 nm NIR-II bio-window. The GL-dependent design eased the penetration of the TiO2-x into the tumor tissues (approximately three-fold). The in vitro and in vivo tests showed that the SDT/PTT-based synergistic treatment achieved more optimized therapeutic effects than the sole use of either SDT or PTT.Conclusion: Our study provided a safety targeted delivery strategy, and enhanced the therapeutic efficiency of SDT/PTT synergistic treatment.

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“…2 ) and hydroxyl radicals (•OH). [18] Moreover, Cu 2 O nanoparticles are also notable inducers of apoptosis in cancer cells. It has proven that these nanoparticles can take up by mitochondria that consequently results in damage of membrane and release of proapoptotic proteins into cytosol.…”

Section: Introductionmentioning

confidence: 99%

NIR‐Mediated Cu₂O/Au Nanomotors for Synergistically Treating Hepatoma Carcinoma Cells

Xian,

Liu,

Song

et al. 2024

Chemistry An Asian Journal

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We presented a NIR‐ driven Janus Cu2O/ Au nanomotor. The nanomotor has a truncated octahedral structure. By asymmetric Au evaporation, the light response range of Cu2O nanomotor is extended to near‐infrared range, and the speed of Cu2O/ Au nanomotors under NIR is significantly increased. In promoting apoptosis of hepatocellular carcinoma, except the nanotoxicity of Cu2O itself, the Au layer enhances the photothermal properties, allowing Cu2O/ Au nanomotors to induce apoptosis in hepatocellular carcinoma cells by heating them. On the other hand, a Schottky barrier formed at the interface of Cu2O and Au, preventing the recombination of electrons, which makes more electrons react with biomolecules to produce toxic ROS to hepatocellular cells. The killing rate of hepatocellular carcinoma cells reached 87% by the combined effect of nanotoxicity inhibition of proliferation and photothermal & photodynamic therapy (PTT & PDT). Nanomotors in combination with multiple approaches to tumor are explored a new treatment in this article.

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Mitochondrial-targeted nanoparticles: Delivery and therapeutic agents in cancer

Cited by 18 publications

References 118 publications

Photodynamic Therapy Induced Mitochondrial Targeting Strategies for Cancer Treatment: Emerging Trends and Insights

Photodynamic Therapy Induced Mitochondrial Targeting Strategies for Cancer Treatment: Emerging Trends and Insights

Glutamine coated titanium for synergistic sonodynamic and photothermal on tumor therapy upon targeted delivery

NIR‐Mediated Cu₂O/Au Nanomotors for Synergistically Treating Hepatoma Carcinoma Cells

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Mitochondrial-targeted nanoparticles: Delivery and therapeutic agents in cancer

Cited by 18 publications

References 118 publications

Photodynamic Therapy Induced Mitochondrial Targeting Strategies for Cancer Treatment: Emerging Trends and Insights

Photodynamic Therapy Induced Mitochondrial Targeting Strategies for Cancer Treatment: Emerging Trends and Insights

Glutamine coated titanium for synergistic sonodynamic and photothermal on tumor therapy upon targeted delivery

NIR‐Mediated Cu2O/Au Nanomotors for Synergistically Treating Hepatoma Carcinoma Cells

Contact Info

Product

Resources

About

NIR‐Mediated Cu₂O/Au Nanomotors for Synergistically Treating Hepatoma Carcinoma Cells