Mitochondrial Support of Embryos From Women of Advanced Maternal Age During Art

Kile, Rebecca; Logsdon, Deirdre M.; Nathanson, Catherine; McCormick, S.; Schoolcraft, William B.; Krisher, Rebecca L.

doi:10.1016/j.fertnstert.2020.08.363

Cited by 2 publications

(2 citation statements)

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“…There were no significant differences between the study and control groups, respectively, regarding the fertilization rates (91% vs. 83%, p = 0.11), D5 (20% vs. 18%) or total (45% vs. 48%) good quality blastocyst development (per zygote), or in total blastocyst development (62% vs. 63%) or euploidy rates (30 vs. 33%). Even though this study did not evaluate CoQ10 supplementation at the oocyte level, it proved the safety of this treatment in in vitro culture, as well as its inefficiency in improving aged women's embryo quality, whose oocytes and subsequent embryos were already affected by the aging process [32].…”

Section: Standard Culturementioning

confidence: 85%

“…High levels of this antioxidant come into close contact with the oocyte, although its apparent positive action at the follicular level is absent. In this context, CoQ10 supplementation does not offer any advantage over the standard culture of fertilized oocytes from women of advanced age [32], which seems logical if we consider that these oocytes had already undergone two consecutive meiotic divisions with age-related damaged cell machinery.…”

Section: Discussionmentioning

confidence: 99%

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Does Coenzyme Q10 Supplementation Improve Human Oocyte Quality?

Rodríguez-Varela

Labarta

2021

IJMS

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Acquiring oocyte competence requires optimal mitochondrial function and adequate ATP levels. In this context, CoQ10 supplementation may improve human oocyte quality and subsequent reproductive performance given its role in ATP synthesis and mitochondrial protection from ROS oxidative damage. In infertility treatments, CoQ10 therapy can be orally supplied to promote a more favorable environment for oocyte development in vivo or by its addition to culture media in an attempt to improve its quality in vitro. Human clinical studies evaluating the impact of CoQ10 on reproductive performance are summarized in this review, although the available data do not clearly prove its ability to improve human oocyte quality. The main objective is to provide readers with a complete overview of this topic’s current status as well as the keys for potential future research lines that may help to take this therapy to clinical practice. Indeed, further clinical trials are needed to confirm these results along with molecular studies to evaluate the impact of CoQ10 supplementation on oxidative stress status and mitochondrial function in human gametes.

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Section: Standard Culturementioning

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Does Coenzyme Q10 Supplementation Improve Human Oocyte Quality?

Rodríguez-Varela

Labarta

2021

IJMS

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Clinical Application of Antioxidants to Improve Human Oocyte Mitochondrial Function: A Review

Rodríguez-Varela

Labarta

2020

Antioxidants

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Mitochondria produce adenosine triphosphate (ATP) while also generating high amounts of reactive oxygen species (ROS) derived from oxygen metabolism. ROS are small but highly reactive molecules that can be detrimental if unregulated. While normally functioning mitochondria produce molecules that counteract ROS production, an imbalance between the amount of ROS produced in the mitochondria and the capacity of the cell to counteract them leads to oxidative stress and ultimately to mitochondrial dysfunction. This dysfunction impairs cellular functions through reduced ATP output and/or increased oxidative stress. Mitochondrial dysfunction may also lead to poor oocyte quality and embryo development, ultimately affecting pregnancy outcomes. Improving mitochondrial function through antioxidant supplementation may enhance reproductive performance. Recent studies suggest that antioxidants may treat infertility by restoring mitochondrial function and promoting mitochondrial biogenesis. However, further randomized, controlled trials are needed to determine their clinical efficacy. In this review, we discuss the use of resveratrol, coenzyme-Q10, melatonin, folic acid, and several vitamins as antioxidant treatments to improve human oocyte and embryo quality, focusing on the mitochondria as their main hypothetical target. However, this mechanism of action has not yet been demonstrated in the human oocyte, which highlights the need for further studies in this field.

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Mitochondrial Support of Embryos From Women of Advanced Maternal Age During Art

Cited by 2 publications

References 0 publications

Does Coenzyme Q10 Supplementation Improve Human Oocyte Quality?

Does Coenzyme Q10 Supplementation Improve Human Oocyte Quality?

Clinical Application of Antioxidants to Improve Human Oocyte Mitochondrial Function: A Review

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