Mitochondrial ROS regulates hepatoma cell invasiveness via NFE2L1

Lee, Eun-beom; Kim, Gyeong-Hyeon; Yoon, Gyesoon

doi:10.1016/j.freeradbiomed.2018.04.463

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Hypoxia Stabilize the Transactivation Activity Of Nrf11

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“…In our analysis, the ARE contained in the pGL3.47 luciferase gene construct served as the direct target DNA binding sequence for Nrf1 (as opposed to Nrf2), therefore, the increased luciferase enzymatic activity was directly proportional to Nrf1 transactivation activity. This result indicated Nrf1 activity was induced by hypoxia treatment; possibly by ROS produced under hypoxic conditions (Lee et al, 2018). However, results from luciferase assays did not show significant differences in Nrf1 transactivation activity between wtNrf1 or mutNrf1 co-expressed with PHD2.…”

Section: Hypoxia Stabilize the Transactivation Activity Of Nrf1mentioning

confidence: 84%