Mitochondrial respiration inhibitor enhances the anti-tumor effect of high-dose ascorbic acid in castration-resistant prostate cancer

Jia, Quanli; Yang, Tianhong; Long, Ya‐Qiu; He, Ping; Shen, Wanqing; Zhang, Bing; Shi, Xiulin; Peng, Lei; Li, Zhoulei; Zhang, Xiangsong

doi:10.1007/s00109-022-02273-5

Cited by 3 publications

(1 citation statement)

References 51 publications

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“…Numerous studies have shown that Met can regulate tumor metabolism, inhibit tumor cell proliferation, migration, and invasion, and induce apoptosis ( 93 , 94 ). More importantly, Met can exert anti-tumor effects by ameliorating hypoxia, chronic inflammation, and the immunosuppressive microenvironment ( 95 ). Recent studies have shown that met significantly downregulates M2 TAM markers and shifts the polarization of TAMs from M2 to M1, thereby inhibiting the pro-tumor effects of M2 TAMs ( 96 , 97 ).…”

Section: Dds Based On Nanoparticles For Cancer Immunotherapymentioning

confidence: 99%

Diverse drug delivery systems for the enhancement of cancer immunotherapy: an overview

Liu,

Cheng,

et al. 2024

Front. Immunol.

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Despite the clear benefits demonstrated by immunotherapy, there is still an inevitable off-target effect resulting in serious adverse immune reactions. In recent years, the research and development of Drug Delivery System (DDS) has received increased prominence. In decades of development, DDS has demonstrated the ability to deliver drugs in a precisely targeted manner to mitigate side effects and has the advantages of flexible control of drug release, improved pharmacokinetics, and drug distribution. Therefore, we consider that combining cancer immunotherapy with DDS can enhance the anti-tumor ability. In this paper, we provide an overview of the latest drug delivery strategies in cancer immunotherapy and briefly introduce the characteristics of DDS based on nano-carriers (liposomes, polymer nano-micelles, mesoporous silica, extracellular vesicles, etc.) and coupling technology (ADCs, PDCs and targeted protein degradation). Our aim is to show readers a variety of drug delivery platforms under different immune mechanisms, and analyze their advantages and limitations, to provide more superior and accurate targeting strategies for cancer immunotherapy.

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Section: Dds Based On Nanoparticles For Cancer Immunotherapymentioning

confidence: 99%

Diverse drug delivery systems for the enhancement of cancer immunotherapy: an overview

Liu,

Cheng,

et al. 2024

Front. Immunol.

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Vitamin‐C‐dependent downregulation of the citrate metabolism pathway potentiates pancreatic ductal adenocarcinoma growth arrest

Cenigaonandia‐Campillo,

Garcia‐Bautista,

Rio‐Vilariño

et al. 2024

Molecular Oncology

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In pancreatic ductal adenocarcinoma (PDAC), metabolic rewiring and resistance to standard therapy are closely associated. PDAC cells show enormous requirements for glucose‐derived citrate, the first rate‐limiting metabolite in the synthesis of new lipids. Both the expression and activity of citrate synthase (CS) are extraordinarily upregulated in PDAC. However, no previous relationship between gemcitabine response and citrate metabolism has been documented in pancreatic cancer. Here, we report for the first time that pharmacological doses of vitamin C are capable of exerting an inhibitory action on the activity of CS, reducing glucose‐derived citrate levels. Moreover, ascorbate targets citrate metabolism towards the de novo lipogenesis pathway, impairing fatty acid synthase (FASN) and ATP citrate lyase (ACLY) expression. Lowered citrate availability was found to be directly associated with diminished proliferation and, remarkably, enhanced gemcitabine response. Moreover, the deregulated citrate‐derived lipogenic pathway correlated with a remarkable decrease in extracellular pH through inhibition of lactate dehydrogenase (LDH) and overall reduced glycolytic metabolism. Modulation of citric acid metabolism in highly chemoresistant pancreatic adenocarcinoma, through molecules such as vitamin C, could be considered as a future clinical option to improve patient response to standard chemotherapy regimens.

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The Role of Vitamin C in the Prevention and Treatment of Cancers

Cheng,

Zhou,

et al. 2024

Advances in Biochemistry in Health and Disease

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Mitochondrial respiration inhibitor enhances the anti-tumor effect of high-dose ascorbic acid in castration-resistant prostate cancer

Cited by 3 publications

References 51 publications

Diverse drug delivery systems for the enhancement of cancer immunotherapy: an overview

Diverse drug delivery systems for the enhancement of cancer immunotherapy: an overview

Vitamin‐C‐dependent downregulation of the citrate metabolism pathway potentiates pancreatic ductal adenocarcinoma growth arrest

The Role of Vitamin C in the Prevention and Treatment of Cancers

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