Mitochondrial respiration in blood platelets of depressive patients

Hroudová, Jana; Fišar, Zdeněk; Kitzlerová, Eva; Zvěřová, Martina; Raboch, Jiří

doi:10.1016/j.mito.2013.05.005

Cited by 99 publications

(81 citation statements)

References 39 publications

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“…In addition, mitochondrial respiration was negatively correlated with early trauma exposure (84). Another study found impaired mitochondrial respiration in platelets of patients with depression (84, 85). With regard to mtDNA copy number, one study did not show alterations in 17–45 year-old Chinese outpatients with MDD compared with matched healthy controls (32).…”

Section: Discussionmentioning

confidence: 96%

Alterations of Mitochondrial DNA Copy Number and Telomere Length With Early Adversity and Psychopathology

Tyrka

Parade

Price

et al. 2016

Biological Psychiatry

227

177

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Background Telomere shortening and alterations of mitochondrial biogenesis are involved in cellular aging. Childhood adversity is associated with telomere shortening, and several investigations have shown short telomeres in psychiatric disorders. Recent studies have examined whether mitochondria might be involved in neuropsychiatric conditions; findings are limited and no prior work has examined this in relation to stress exposure. Methods Two-hundred and ninety healthy adults provided information on childhood parental loss and maltreatment and completed diagnostic interviews. Participants were categorized into four groups based upon the presence or absence of childhood adversity and the presence or absence of lifetime psychopathology (depressive, anxiety, and substance use disorders). Telomere length and mtDNA copy number were measured from leukocyte DNA by qPCR. Results Childhood adversity and lifetime psychopathology were each associated with shorter telomeres (p < .01) and higher mtDNA copy numbers (p < .001). Significantly higher mtDNA copy numbers and shorter telomeres were seen in individuals with major depression, depressive disorders, and anxiety disorders, as well as those with parental loss and childhood maltreatment. A history of substance disorders was also associated with significantly higher mtDNA copy numbers. Conclusion This study provides the first evidence of an alteration of mitochondrial biogenesis with early life stress and with anxiety and substance use disorders. We replicate prior work on telomere length and psychopathology, and show that this effect is not secondary to medication use or comorbid medical illness. Finally, we show that early life stress and psychopathology are each associated with these markers of cellular aging.

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Section: Discussionmentioning

confidence: 96%

Alterations of Mitochondrial DNA Copy Number and Telomere Length With Early Adversity and Psychopathology

Tyrka

Parade

Price

et al. 2016

Biological Psychiatry

227

177

View full text Add to dashboard Cite

show abstract

“…rCBF is improved by treatment including cognitive-behavioral and electroconvulsive therapy (ECT) in MDD [4]–[5], suggesting a state related change. This may be linked to reduced mitochondrial energy generation and dysfunction in the disorder [6]–[7]. In parallel, there is a large literature showing alterations in brain glucose utilization in depression [8].…”

Section: Introductionmentioning

confidence: 99%

Assessing Regional Cerebral Blood Flow in Depression Using 320-Slice Computed Tomography

et al. 2014

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While there is evidence that the development and course of major depressive disorder (MDD) symptomatology is associated with vascular disease, and that there are changes in energy utilization in the disorder, the extent to which cerebral blood flow is changed in this condition is not clear. This study utilized a novel imaging technique previously used in coronary and stroke patients, 320-slice Computed-Tomography (CT), to assess regional cerebral blood flow (rCBF) in those with MDD and examine the pattern of regional cerebral perfusion. Thirty nine participants with depressive symptoms (Hamilton Depression Rating Scale 24 (HAMD24) score >20, and Self-Rating Depression Scale (SDS) score >53) and 41 healthy volunteers were studied. For all subjects, 3 ml of venous blood was collected to assess hematological parameters. Trancranial Doppler (TCD) ultrasound was utilized to measure parameters of cerebral artery rCBFV and analyse the Pulsatility Index (PI). 16 subjects (8 = MDD; 8 = healthy) also had rCBF measured in different cerebral artery regions using 320-slice CT. Differences among groups were analyzed using ANOVA and Pearson's tests were employed in our statistical analyses. Compared with the control group, whole blood viscosity (including high\middle\low shear rate)and hematocrit (HCT) were significantly increased in the MDD group. PI values in different cerebral artery regions and parameters of rCBFV in the cerebral arteries were decreased in depressive participants, and there was a positive relationship between rCBFV and the corresponding vascular rCBF in both gray and white matter. rCBF of the left gray matter was lower than that of the right in MDD. Major depression is characterized by a wide range of CBF impairments and prominent changes in gray matter blood flow. 320-slice CT appears to be a valid and promising tool for measuring rCBF, and could thus be employed in psychiatric settings for biomarker and treatment response purposes.

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“…In particular, damage to the mitochondrial electron transport chain has been suggested as an important factor in the pathogenesis of a range of neuropsychiatric disorders, including depression . For example, decreased mitochondrial respiratory rate may play a role in pathophysiology of depression in humans . In addition, previous work demonstrated that mitochondrial respiratory chain activity is impaired in animal models of depression (induced via chronic stress) .…”

Section: Introductionmentioning

confidence: 69%

“…18,19,22 For example, decreased mitochondrial respiratory rate may play a role in pathophysiology of depression in humans. 23 In addition, previous work demonstrated that mitochondrial respiratory chain activity is impaired in animal models of depression (induced via chronic stress). 24 This work demonstrated that mitochondrial respiratory chain complexes I, III, and IV were inhibited in the stress group but that complex II was not affected.…”

mentioning

confidence: 99%

Mitochondrial DNA m.13514G>A heteroplasmy is associated with depressive symptoms in the elderly

Tranah

Maglione

Yaffe

et al. 2018

Int J Geriat Psychiatry

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Mitochondrial respiration in blood platelets of depressive patients

Cited by 99 publications

References 39 publications

Alterations of Mitochondrial DNA Copy Number and Telomere Length With Early Adversity and Psychopathology

Alterations of Mitochondrial DNA Copy Number and Telomere Length With Early Adversity and Psychopathology

Assessing Regional Cerebral Blood Flow in Depression Using 320-Slice Computed Tomography

Mitochondrial DNA m.13514G>A heteroplasmy is associated with depressive symptoms in the elderly

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