Mitochondrial-related gene expression profiles suggest an important role of PGC-1alpha in the compensatory mechanism of endemic dilated cardiomyopathy

He, Shulan; Tan, Wenfeng; Zhang, Zengtie; Zhang, Feng; Qu, Chengjuan; Lei, Yanxia; Zhu, Yulan; Yu, Hanjie; Xiang, Youzhang; Guo, Xiong

doi:10.1016/j.yexcr.2013.07.018

Cited by 10 publications

(4 citation statements)

References 35 publications

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“…The researchers found that six nuclear receptorrelated pathways and eight genes, as well as four energy production-related pathways and five genes are upregulated in KD and PGC-1α-induced energy production plays an important role in the compensatory mechanism of KD. 397 Recently, Jiang et al discovered that the mRNA levels of PGC-1α, NRF1, and PPARα are higher in patients with KD. Notably, the area under the curve for the "lactate dehydrogenase (LDH) + PPARα" combination was 0.984, with 96.7% sensitivity and 93.0% specificity, indicating that the combined detection of LDH and PPARα can be performed to diagnose chronic KD.…”

Section: The Role Of Pgc-1s In Pathophysiological Processes and Disea...mentioning

confidence: 99%

Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family in physiological and pathophysiological process and diseases

Qian,

Zhu,

Deng

et al. 2024

Sig Transduct Target Ther

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Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family (PGC-1s), consisting of three members encompassing PGC-1α, PGC-1β, and PGC-1-related coactivator (PRC), was discovered more than a quarter-century ago. PGC-1s are essential coordinators of many vital cellular events, including mitochondrial functions, oxidative stress, endoplasmic reticulum homeostasis, and inflammation. Accumulating evidence has shown that PGC-1s are implicated in many diseases, such as cancers, cardiac diseases and cardiovascular diseases, neurological disorders, kidney diseases, motor system diseases, and metabolic disorders. Examining the upstream modulators and co-activated partners of PGC-1s and identifying critical biological events modulated by downstream effectors of PGC-1s contribute to the presentation of the elaborate network of PGC-1s. Furthermore, discussing the correlation between PGC-1s and diseases as well as summarizing the therapy targeting PGC-1s helps make individualized and precise intervention methods. In this review, we summarize basic knowledge regarding the PGC-1s family as well as the molecular regulatory network, discuss the physio-pathological roles of PGC-1s in human diseases, review the application of PGC-1s, including the diagnostic and prognostic value of PGC-1s and several therapies in pre-clinical studies, and suggest several directions for future investigations. This review presents the immense potential of targeting PGC-1s in the treatment of diseases and hopefully facilitates the promotion of PGC-1s as new therapeutic targets.

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Section: The Role Of Pgc-1s In Pathophysiological Processes and Disea...mentioning

confidence: 99%

Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family in physiological and pathophysiological process and diseases

Qian,

Zhu,

Deng

et al. 2024

Sig Transduct Target Ther

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“…Meanwhile, the activity of oxidative phosphorylation enzymes was significant reduced in the mitochondria of KD patients 9 . Mitochondria-related gene expression profiles have been shown to be different between KD patients and healthy controls 10 .…”

Section: Discussionmentioning

confidence: 99%

Prediction of co-expression genes and integrative analysis of gene microarray and proteomics profile of Keshan disease

Wang

Yan

Wang³

et al. 2018

Sci Rep

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Keshan disease (KD) is a kind of endemic cardiomyopathy which has a high mortality. However, molecular mechanism in the pathogenesis of KD remains poorly understood. Serum samples were collected from 112 KD patients and 112 normal controls. Gene microarray was used to screen differently expressed genes. Genevestigator was applied to forecast co-expression genes of significant gene. iTRAQ proteomics analysis was used to verify significant genes and their co-expression genes. GO, COG, IPA and STRING were applied to undertake function categorization, pathway and network analysis separately. We identified 32 differentially expressed genes; IDH2, FEM1A, SSPB1 and their respective 30 co-expression genes; 68 differential proteins in KD. Significant proteins were categorized into 23 biological processes, 16 molecular functions, 16 cellular components, 15 function classes, 13 KD pathways and 1 network. IDH2, FEM1A, SSBP1, CALR, NDUFS2, IDH3A, GAPDH, TCA Cycle II (Eukaryotic) pathway and NADP repair pathway may play important roles in the pathogenesis of KD.

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“…Recent studies have also indicated that CYP1A1 and CYP2C19 are highly expressed (ratios ≥2.0) in patients with KD (11). These genes belong to the cytochrome P450 isoforms, and their metabolites are biologically active and critical for the maintenance of essential bodily functions (12,13). KD is widely considered a multifactorial environmentgene interaction complex disease.…”

Section: Introductionmentioning

confidence: 99%

Keshan Disease: A Potentially Fatal Endemic Cardiomyopathy in Remote Mountains of China

et al. 2021

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Keshan disease (KD) as an endemic, highly lethal cardiomyopathy, first reported in northeast China's Keshan County in 1935. The clinical manifestations of patients with KD include primarily congestive heart failure, acute heart failure, and cardiac arrhythmia. Even though some possible etiologies, such as viral infection, fungal infection, microelement deficiency, and malnutrition, have been reported, the exact causes of KD remain poorly known. The endemic areas where KD is found are remote and rural, and many are poor and mountainous places where people are the most socioeconomically disadvantaged in terms of housing, income, education, transportation, and utilization of health services. To date, KD is a huge burden to and severely restricts the economic development of the local residents and health systems of the endemic areas. Although efforts have been made by the government to control, treat, and interrupt disease transmission, the cure for or complete eradication of KD still requires global attention. For this reason, in this review, we systematically describe the etiological hypothesis, clinical manifestations, incidence characteristics, and treatment of KD, to facilitate the better understanding of and draw more attention to this non-representative cardiovascular disease, with the aim of accelerating its elimination.

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Mitochondrial-related gene expression profiles suggest an important role of PGC-1alpha in the compensatory mechanism of endemic dilated cardiomyopathy

Cited by 10 publications

References 35 publications

Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family in physiological and pathophysiological process and diseases

Peroxisome proliferator-activated receptor gamma coactivator-1 (PGC-1) family in physiological and pathophysiological process and diseases

Prediction of co-expression genes and integrative analysis of gene microarray and proteomics profile of Keshan disease

Keshan Disease: A Potentially Fatal Endemic Cardiomyopathy in Remote Mountains of China

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