Mitochondrial Reactive Oxygen Species Elicit Acute and Chronic Itch via Transient Receptor Potential Canonical 3 Activation in Mice

Kim, Seong-Ah; Jang, Jun Ho; Kim, Wheedong; Lee, Pa Reum; Kim, Yong Ho; Vang, Hue; Lee, Kihwan; Oh, Seog Bae

doi:10.1007/s12264-022-00837-6

Cited by 8 publications

(8 citation statements)

References 73 publications

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“…Using a mouse cheek model of dry skin-induced chronic itch, Oh's team demonstrated that TRPC3 but not TRPA1 and TRPV1 contributes to dry skin-induced itch. They also showed increased mROS levels in the dry skin [11]. Therefore, TRPC3 may serve as a new therapeutic target for itch.…”

mentioning

confidence: 93%

Third Special Issue on Mechanisms of Pain and Itch

2022

Neurosci. Bull.

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mentioning

confidence: 93%

Third Special Issue on Mechanisms of Pain and Itch

2022

Neurosci. Bull.

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“…For the TRPC channels, TRPC1, TRPC4, and TRPC5 are activated directly by inositol-1,4,5-trisphosphate, and TRPC3, TRPC6, and TRPC7 are activated by diacylglycerol (DAG), independent of the storage reduction of intracellular calcium [ 16 ]. The TRPC channels have been reported to play important roles in both the nociceptor signaling and the sensitization of the nociceptors by the inflammatory mediators [ 25 ]. This previous study [ 25 ] revealed a major contribution of TRPC to the neuronal calcium homeostasis in the somatosensory pathways.…”

Section: Introductionmentioning

confidence: 99%

“…The TRPC channels have been reported to play important roles in both the nociceptor signaling and the sensitization of the nociceptors by the inflammatory mediators [ 25 ]. This previous study [ 25 ] revealed a major contribution of TRPC to the neuronal calcium homeostasis in the somatosensory pathways. These channels are non selectively permeable to cations, with variable selectivity for calcium over sodium among the different members.…”

Section: Introductionmentioning

confidence: 99%

“…We previously reported that a SNP near the TRPC3 gene was associated with the postoperative fentanyl requirements and pain [ 27 ]. Several studies of the TRPC3 gene polymorphisms and chronic itch have been reported [ 25 , 28 ], but no studies have evaluated the associations between the TRPC3 gene polymorphisms and chronic pain. In the present study, we investigated the genetic polymorphisms within and around the TRPC3 gene and analyzed the TRPC3 gene polymorphisms that influence chronic pain.…”

Section: Introductionmentioning

confidence: 99%

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Rs11726196 Single-Nucleotide Polymorphism of the Transient Receptor Potential Canonical 3 (TRPC3) Gene Is Associated with Chronic Pain

Aoki

Nishizawa

Ohka

et al. 2023

IJMS

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Chronic pain is reportedly associated with the transient receptor potential canonical 3 (TRPC3) gene. The present study examined the genetic associations between the single-nucleotide polymorphisms (SNPs) of the TRPC3 gene and chronic pain. The genomic samples from 194 patients underwent linkage disequilibrium (LD) analyses of 29 SNPs within and around the vicinity of the TRPC3 gene. We examined the associations between the SNPs and the susceptibility to chronic pain by comparing the genotype distribution of 194 patients with 282 control subjects. All SNP genotype data were extracted from our previous whole-genome genotyping results. Twenty-nine SNPs were extracted, and a total of four LD blocks with 15 tag SNPs were observed within and around the TRPC3 gene. We further analyzed the associations between these tag SNPs and chronic pain. The rs11726196 SNP genotype distribution of patients was significantly different from the control subjects even after multiple-testing correction with the number of SNPs. The TT + TG genotype of rs11726196 is often carried by chronic pain patients, suggesting a causal role for the T allele. These results contribute to our understanding of the genetic risk factors for chronic pain.

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“…Interestingly, chronic pruritus is a common feature of many of these diseases. Recently, it has also been shown that mitochondrial reactive oxygen species (mROS) may play a role in pain processing and that mitochondrial dysfunction can contribute to painful peripheral neuropathies [6] .…”

mentioning

confidence: 99%

Role of antioxidants in itch treatment: lessons learned from pain management

Soares¹,

Mahmoud²,

Yosipovitch³

2023

Itch

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Chronic pain and chronic pruritus are both debilitating conditions that cause a significant burden to patients. Oxidative stressdriven by an imbalance between reactive oxygen species and antioxidants-has been shown to play a role both in pain disorders and conditions in which chronic itch is a prominent symptom. Antioxidants can be useful in treating oxidative stress-driven diseases and have shown promise in treating chronic pain conditions such as fibromyalgia and osteoarthritis. However, their role in treating pruritus and pruritic conditions such as psoriasis and atopic dermatitis remains unclear. Many of the current treatments for chronic itch are costly, associated with side effects, and have limited efficacy. Therefore, further controlled studies exploring antioxidants as a potential therapeutic option for chronic pruritus are warranted.

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Mitochondrial Reactive Oxygen Species Elicit Acute and Chronic Itch via Transient Receptor Potential Canonical 3 Activation in Mice

Cited by 8 publications

References 73 publications

Third Special Issue on Mechanisms of Pain and Itch

Third Special Issue on Mechanisms of Pain and Itch

Rs11726196 Single-Nucleotide Polymorphism of the Transient Receptor Potential Canonical 3 (TRPC3) Gene Is Associated with Chronic Pain

Role of antioxidants in itch treatment: lessons learned from pain management

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