Mitochondrial quality control in acute kidney disease

Sheng, Jingyi; Li, Xian; Lei, Juan; Gan, Weihua; Song, Jiayu

doi:10.1007/s40620-023-01582-3

Cited by 2 publications

(1 citation statement)

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“…Significant emphasis has been placed on preserving mitochondrial biogenesis and maintaining mitochondrial integrity during processes of injury and repair. 68 Furthermore, Chung, et al 69 recently introduced a hypothesis that the release of mitochondria DNA (mtDNA) during AKI can trigger immune responses and injury progression. They demonstrated that mitochondrial transcription factor A is depleted in fibrotic kidneys of both human and murine subjects, providing additional insights into its impact on mitochondria and subsequent translocation of mtDNA into the cytosol.…”

Section: Aki-to-ckd Transition: Recent Mechanistic Insightsmentioning

confidence: 99%

Recent Update on Acute Kidney Injury-to-Chronic Kidney Disease Transition

Koh,

Chung

2024

Yonsei Med J

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Acute kidney injury (AKI) is characterized by an abrupt decline of excretory kidney function. The incidence of AKI has increased in the past decades. Patients diagnosed with AKI often undergo diverse clinical trajectories, such as early or late recovery, relapses, and even a potential transition from AKI to chronic kidney disease (CKD). Although recent clinical studies have demonstrated a strong association between AKI and progression of CKD, our understanding of the complex relationship between AKI and CKD is still evolving. No cohort study has succeeded in painting a comprehensive picture of these multi-faceted pathways. To address this lack of understanding, the idea of acute kidney disease (AKD) has recently been proposed. This presents a new perspective to pinpoint a period of heightened vulnerability following AKI, during which a patient could witness a substantial decline in glomerular filtration rate, ultimately leading to CKD transition. Although AKI is included in a range of kidney conditions collectively known as AKD, spanning from mild and self-limiting to severe and persistent, AKD can also occur without a rapid onset usually seen in AKI, such as when kidney dysfunction slowly evolves. In the present review, we summarize the most recent findings about AKD, explore the current state of biomarker discovery related to AKD, discuss the latest insights into pathophysiological underpinnings of AKI to CKD transition, and reflect on therapeutic challenges and opportunities that lie ahead.

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Section: Aki-to-ckd Transition: Recent Mechanistic Insightsmentioning

confidence: 99%