Mitochondrial physiology varies with parity and body mass in the laboratory mouse (Mus musculus)

Park, Noel R.; Taylor, Halie A.; Andreasen, Victoria A.; Williams, Ashley S; Niitepõld, Kristjan; Yap, Kang Nian; Kavazis, Andreas N.; Hood, Wendy R.

doi:10.1007/s00360-020-01285-2

Cited by 7 publications

(6 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Oxidative stress during pregnancy is in uenced by lifestyle factors, such as socioeconomic status (49). In addition, animal studies showed that parity in uenced mitochondrial enzyme activity (50) and respiratory capacity (51). Furthermore, we found that gestational age was linked with cord blood MT-D-Loop 16362T > C heteroplasmy, which can be explained due to an increase in oxidative stress as gestation progresses (52).…”

Section: Discussionmentioning

confidence: 57%

Exploring Mitochondrial Heteroplasmy in Neonates: Implications for Growth Patterns in the First Years of Life

Cosemans,

Alfano,

Sleurs

et al. 2023

Preprint

View full text Add to dashboard Cite

Background: Mitochondrial heteroplasmy reflects genetic diversity within individuals due to the presence of varying mitochondrial DNA (mtDNA) sequences, possibly affecting mitochondrial function and energy production in cells. Rapid growth during early childhood is a critical development with long-term implications for health and well-being. In this study, we investigated if cord blood mtDNA heteroplasmy is associated with rapid growth at six and 12 months and overweight in childhood at four to six years. Methods: This study included 200 mother-child pairs of the ENVIRONAGE birth cohort. Whole mitochondrial genome sequencing was performed to determine mtDNA heteroplasmy levels (in variant allele frequency; VAF) in cord blood. Rapid growth was defined for each child as the difference between WHO-SD scores of predicted weight at either six or 12 months and birth weight. Logistic regression models were used to determine the association of mitochondrial heteroplasmy with rapid growth and childhood overweight. Determinants of relevant cord blood mitochondrial heteroplasmies were identified using multiple linear regression models. Results: One % increase in VAF of cord blood MT-D-Loop16362T>C heteroplasmy was associated with rapid growth at six (OR=1.03; 95% CI: 1.01 to 1.05; p=0.001) and 12 months (OR=1.02; 95% CI: 1.00 to 1.03; p=0.02). Furthermore, this variant was associated with childhood overweight at four to six years (OR=1.01; 95% CI 1.00 to 1.02; p=0.05). Additionally, rapid growth at six (OR=3.00; 95% CI: 1.49 to 6.14; p=0.002) and 12 months (OR=4.05; 95% CI: 2.06 to 8.49; p<0.001) was also associated with childhood overweight at four to six years. Furthermore, we identified maternal age, pre-pregnancy BMI, maternal education, parity, and gestational age as determinants of cord blood MT-D-Loop16362T>C heteroplasmy. Conclusions: Our findings, based on mitochondrial DNA genotyping, offer insights into the molecular machinery leading to rapid growth in early life, potentially explaining a working mechanism of the development towards childhood overweight.

show abstract

Section: Discussionmentioning

confidence: 57%

Exploring Mitochondrial Heteroplasmy in Neonates: Implications for Growth Patterns in the First Years of Life

Cosemans,

Alfano,

Sleurs

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…A number of important works have described parity-induced alterations in the brain lasting beyond delivery and even weaning (reviewed in Puri et al, 2023). Indeed, reproductive events have been found to alter mitochondrial capacity in the liver as well as organ-specific responses to oxidative stress (Wood et al, 2019;Park et al, 2020). It is therefore tempting to speculate that altered brain mitochondrial function might underlie or associate with these adaptations.…”

Section: Discussionmentioning

confidence: 99%

Mitochondrial might: powering the peripartum for risk and resilience

Gorman-Sandler,

Wood,

Cloude

et al. 2023

Front. Behav. Neurosci.

View full text Add to dashboard Cite

The peripartum period, characterized by dynamic hormonal shifts and physiological adaptations, has been recognized as a potentially vulnerable period for the development of mood disorders such as postpartum depression (PPD). Stress is a well-established risk factor for developing PPD and is known to modulate mitochondrial function. While primarily known for their role in energy production, mitochondria also influence processes such as stress regulation, steroid hormone synthesis, glucocorticoid response, GABA metabolism, and immune modulation – all of which are crucial for healthy pregnancy and relevant to PPD pathology. While mitochondrial function has been implicated in other psychiatric illnesses, its role in peripartum stress and mental health remains largely unexplored, especially in relation to the brain. In this review, we first provide an overview of mitochondrial involvement in processes implicated in peripartum mood disorders, underscoring their potential role in mediating pathology. We then discuss clinical and preclinical studies of mitochondria in the context of peripartum stress and mental health, emphasizing the need for better understanding of this relationship. Finally, we propose mitochondria as biological mediators of resilience to peripartum mood disorders.

show abstract

“…An experimental medicine study stated that the energy costs of reproduction may reduce an animal's ability to support self-maintenance and longevity. 32 It showed that female mice that allocated more to reproduction had lower basal respiration, lower mitochondrial density, and higher protein oxidation in liver mitochondria than females that allocated less. These results suggest that through their first four reproductive events, mice may experience bioenergetic benefits from reproduction, but only those females that allocated the most to reproduction seem to experience a potential cost of reproduction.…”

Section: Discussionmentioning

confidence: 99%

“…However, we could not specifically assess, because of the low number of women, whether those mothers with five or more children had less longevity. An experimental medicine study stated that the energy costs of reproduction may reduce an animal's ability to support self-maintenance and longevity 32 . It showed that female mice that allocated more to reproduction had lower basal respiration, lower mitochondrial density, and higher protein oxidation in liver mitochondria than females that allocated less.…”

Section: Discussionmentioning

confidence: 99%

Health screening of middle-aged women: what factors impact longevity?

et al. 2022

View full text Add to dashboard Cite

Objective: The aim of this study was to measure the impact of different risk factors in middle-aged women on longevity evaluated after three decades of an initial health screening.Methods: Women who received an annual check-up between 1990 and 1993 were recruited. Anamnesis and physical examination were recorded. Blood samples for the measurement of glycemia and lipids were taken. Data are reported as of December 2021.Results: A total of 1,158 women aged 40 to 60 were studied. At 30.9 years of follow-up, the Kaplan-Meier overall survival was 75.6% (95% confidence interval, 72.6-78.3). The main causes of the 260 deaths observed were the following: cancer (n = 88; 33.8%), cardiovascular disease (n = 55; 21.2%), and infectious disease (n = 41; 15.8%). The following hazard ratios were found with the flexible parametric survival model:

show abstract

Mitochondrial physiology varies with parity and body mass in the laboratory mouse (Mus musculus)

Cited by 7 publications

References 56 publications

Exploring Mitochondrial Heteroplasmy in Neonates: Implications for Growth Patterns in the First Years of Life

Exploring Mitochondrial Heteroplasmy in Neonates: Implications for Growth Patterns in the First Years of Life

Mitochondrial might: powering the peripartum for risk and resilience

Health screening of middle-aged women: what factors impact longevity?

Contact Info

Product

Resources

About