Mitochondrial OXPHOS is involved in the protective effects of L-arginine against heat-induced low sperm motility of boar

Li, Yansen; Chen, Jiaqin; Li, Zhaojian; Li, Chunmei

doi:10.1016/j.jtherbio.2019.07.008

Cited by 16 publications

(24 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Semen preservation is an effective modality to preserve male genetic resources, which solves some problems caused by male infertility (Botchan et al, 2013). Nevertheless, the accumulation of excessive ROS during storage causes oxidative damage to boar sperm (Li et al, 2019). Some studies have shown that the activation of AMPK reduces the production of cellular mitochondrial ROS, which stimulated research on its potential in sperm preservation (Calle-Guisado et al, 2017;Zhu et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Rosmarinic acid improves boar sperm quality, antioxidant capacity and energy metabolism at 17°C via AMPK activation

Feng

Zhang

et al. 2020

Reprod Domestic Animals

View full text Add to dashboard Cite

The application of artificial insemination (AI) makes full use of the sperm of boars with excellent qualities and improved economic benefits (Berger & Conley, 2014). The storage of boar sperm at 17°C, as a common sperm preservation technique, inhibits sperm movement and reduces energy consumption such that sperm survive longer in vitro (Zhu et al., 2020). However, the quality and fertility of boar sperm decrease with storage time (Basioura et al., 2018). The plasma membrane of boar sperm contains a high concentration of polyunsaturated fatty acids and has a low cholesterol/phospholipid ratio (Davis, 1981). These characteristics make boar sperm more

show abstract

Section: Discussionmentioning

confidence: 99%

Rosmarinic acid improves boar sperm quality, antioxidant capacity and energy metabolism at 17°C via AMPK activation

Feng

Zhang

et al. 2020

Reprod Domestic Animals

View full text Add to dashboard Cite

show abstract

“…Boar sperm exposed to high temperature (39°C) showed a significant reduction in the sperm ATP content (p < .05; Li et al, 2019).…”

Section: Atp Contentmentioning

confidence: 96%

“…The exposure of boar sperm to heat stress up to 39°C causes a significant decrease in mitochondrial membrane potential (MMP; Li et al, 2019). In ram, when testis was exposed to testicular insulation (an isolating sack was put around the treated animal testicles to initiate heat stress-induced impairment of spermatogenesis), lower numbers of sperm were observed with high MMP (Hamilton et al, 2016).…”

Section: Mitochondrial Memb R Ane P Otentialmentioning

confidence: 99%

“…Based on this information, variations in factors of transcription including nuclear respiratory factor 1 (NRF-1) and PGC-1α could exhibit a vital role in sustaining sperm mitochondria ATP synthesis during HS conditions. In this sense, significant elevation in the relative mRNA expression of peroxisome proliferator-activated receptor-gamma coactivator-1 alpha (PGC-1α) and nuclear respiratory factor 1 (NRF-1) was observed in sperm subjected to heat shock (Li et al, 2019). The negative impacts of HS involved several detrimental mechanisms.…”

Section: During Sperm Differentiation Transcription Factors Such As P...mentioning

confidence: 99%

“…In this sense, several antioxidants (Abdelnour et al, 2021;Attia et al, 2015;De Luca et al, 2021;Li et al, 2019;Qiao et al, 2021;Shahat et al, 2022) have been used in enhancing sperm mitochondrial function during adverse environmental stress such HS. Studying the detrimental effects of Hs on sperm mitochondrial function could help us to increase our acknowledge regarding developing new approaches for mitigating HS through using mitochondria enhancers.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Responses of sperm mitochondria functionality in animals to thermal stress: The mitigating effects of dietary natural antioxidants

Abdelnour

Swelum

Sindi

et al. 2022

Reprod Domestic Animals

View full text Add to dashboard Cite

The reproductive consequences of global warming representing heat stress (HS) have been widely received more attention in the last decades. HS induced significant influence on the male reproductive cell, especially sperm functionally. Reduction in the sperm function induced by HS leads to failure of fertility potential. The main effects of HS on sperm are reducing sperm motility, increased abnormalities and changes in the fluidity of the membrane as well as cell morphology. Moreover, the destruction of mitochondrial function could be the result of adverse influences of HS. The protein contents and enzymes of mitochondria were lowered after the exposure of sperm to HS. Some natural antioxidants were used for improving sperm mitochondrial function under HS conditions. In this review, it was highlighted the potential influences of HS on sperm function through reduction in ATP Synthesis yield, mitochondrial activity, mitochondrial protein contents and mitochondrial enzymes, which involves the interference of mitochondrial remodelling in sperm of animals.

show abstract

The significant mechanism and treatments of cell death in heatstroke

Wang,

Zhu,

Zhang

et al. 2024

Apoptosis

View full text Add to dashboard Cite

Mitochondrial OXPHOS is involved in the protective effects of L-arginine against heat-induced low sperm motility of boar

Cited by 16 publications

References 40 publications

Rosmarinic acid improves boar sperm quality, antioxidant capacity and energy metabolism at 17°C via AMPK activation

Rosmarinic acid improves boar sperm quality, antioxidant capacity and energy metabolism at 17°C via AMPK activation

Responses of sperm mitochondria functionality in animals to thermal stress: The mitigating effects of dietary natural antioxidants

The significant mechanism and treatments of cell death in heatstroke

Contact Info

Product

Resources

About