Mitochondrial noncoding RNA-regulatory network in cardiovascular disease

Jusić, Amela; Devaux, Yvan; Action, EU-CardioRNA Cost

doi:10.1007/s00395-020-0783-5

Cited by 77 publications

(69 citation statements)

References 132 publications

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“…Cardiac contraction is powered by ATP administration, which is produced within mitochondria through oxidative phosphorylation process on fatty acid, while glucose oxidation or glycolysis could also supply some energy under hypoxia condition 27 . Mitochondria is the multifunctional cell organelle involved in essential functions of cardiomyocytes, including maintain morphology of cardiomyocyte via mitochondrial dynamics process, reactive oxygen species (ROS) accumulation, calcium transportation by uniporter located on mitochondrial membrane, apart from energy generation 29 . Pathological hypertrophy is associated with mitochondria dysfunction 27 .…”

Section: Lncrnas In Regulation Of Pathophysiological Process Of Cardimentioning

confidence: 99%

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LncRNAs in cardiac hypertrophy: From basic science to clinical application

Liu

Zhang

2020

J Cellular Molecular Medi

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Section: Lncrnas In Regulation Of Pathophysiological Process Of Cardimentioning

confidence: 99%

“…volved in essential functions of cardiomyocytes, including maintain morphology of cardiomyocyte via mitochondrial dynamics process, reactive oxygen species (ROS) accumulation, calcium transportation by uniporter located on mitochondrial membrane, apart from energy generation 29. Pathological hypertrophy is associated with mitochondria dysfunction 27.…”

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confidence: 99%

LncRNAs in cardiac hypertrophy: From basic science to clinical application

Liu

Zhang

2020

J Cellular Molecular Medi

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“…A number of proteins involved in mitochondrial metabolism are regulated in a sex-specific manner and targeted by sex-specific miRNA regulation. Mitochondrial dysfunction may result in unique transcriptional landscape, leading to impaired cardiovascular function, in which dysregulated ncRNA encoded either by nuclear or mitochondrial genome may play critical role [ 132 ]. Including both females and males in the investigation of mitochondrial ncRNA regulatory network in sex-specific mitochondrial dysfunction may lead to opportunity of development of improved and tailored diagnostic and therapeutic approaches for mitochondrial dysfunction-related CVD.…”

Section: Experimental Models To Study Sex-related Ncrna Differencementioning

confidence: 99%

Approaching Sex Differences in Cardiovascular Non-Coding RNA Research

Jusić

Salgado-Somoza

Paes

et al. 2020

IJMS

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Cardiovascular disease (CVD) is the biggest cause of sickness and mortality worldwide in both males and females. Clinical statistics demonstrate clear sex differences in risk, prevalence, mortality rates, and response to treatment for different entities of CVD. The reason for this remains poorly understood. Non-coding RNAs (ncRNAs) are emerging as key mediators and biomarkers of CVD. Similarly, current knowledge on differential regulation, expression, and pathology-associated function of ncRNAs between sexes is minimal. Here, we provide a state-of-the-art overview of what is known on sex differences in ncRNA research in CVD as well as discussing the contributing biological factors to this sex dimorphism including genetic and epigenetic factors and sex hormone regulation of transcription. We then focus on the experimental models of CVD and their use in translational ncRNA research in the cardiovascular field. In particular, we want to highlight the importance of considering sex of the cellular and pre-clinical models in clinical studies in ncRNA research and to carefully consider the appropriate experimental models most applicable to human patient populations. Moreover, we aim to identify sex-specific targets for treatment and diagnosis for the biggest socioeconomic health problem globally.

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“…miR-1 is responsible for protecting heart structure and functions against hypertrophy, maintaining cardiovascular health. Thus, miR-1 is one of the crucial regulators of pathological cardiac hypertrophy by fine-tuning the translation of different molecules, including eukaryotic initiation factor 4E (EIF4E), Mef2a, Gata4 and histone deacetylase 6 (HDAC6) [ 102 , 103 ]. MiR-1 also reduces the cardiac hypertrophic response by negatively impacting calmodulin involved in calcium signaling [ 104 ] via directly targeting heart-specific fat binding protein 2 (FABP3).…”

Section: Mitochondrial Mirnas—potential Contribution For Regeneratmentioning

confidence: 99%

Mitochondrial microRNAs: A Putative Role in Tissue Regeneration

Rodrigues

Cardoso

Duarte

2020

Biology

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The most famous role of mitochondria is to generate ATP through oxidative phosphorylation, a metabolic pathway that involves a chain of four protein complexes (the electron transport chain, ETC) that generates a proton-motive force that in turn drives the ATP synthesis by the Complex V (ATP synthase). An impressive number of more than 1000 mitochondrial proteins have been discovered. Since mitochondrial proteins have a dual genetic origin, it is predicted that ~99% of these proteins are nuclear-encoded and are synthesized in the cytoplasmatic compartment, being further imported through mitochondrial membrane transporters. The lasting 1% of mitochondrial proteins are encoded by the mitochondrial genome and synthesized by the mitochondrial ribosome (mitoribosome). As a result, an appropriate regulation of mitochondrial protein synthesis is absolutely required to achieve and maintain normal mitochondrial function. Regarding miRNAs in mitochondria, it is well-recognized nowadays that several cellular mechanisms involving mitochondria are regulated by many genetic players that originate from either nuclear- or mitochondrial-encoded small noncoding RNAs (sncRNAs). Growing evidence collected from whole genome and transcriptome sequencing highlight the role of distinct members of this class, from short interfering RNAs (siRNAs) to miRNAs and long noncoding RNAs (lncRNAs). Some of the mechanisms that have been shown to be modulated are the expression of mitochondrial proteins itself, as well as the more complex coordination of mitochondrial structure and dynamics with its function. We devote particular attention to the role of mitochondrial miRNAs and to their role in the modulation of several molecular processes that could ultimately contribute to tissue regeneration accomplishment.

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Mitochondrial noncoding RNA-regulatory network in cardiovascular disease

Cited by 77 publications

References 132 publications

LncRNAs in cardiac hypertrophy: From basic science to clinical application

LncRNAs in cardiac hypertrophy: From basic science to clinical application

Approaching Sex Differences in Cardiovascular Non-Coding RNA Research

Mitochondrial microRNAs: A Putative Role in Tissue Regeneration

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