2013
DOI: 10.1016/j.bbamcr.2012.02.012
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Mitochondrial morphology in mitophagy and macroautophagy

Abstract: Mitochondria are critical organelles in energy conversion, metabolism and amplification of signalling. They are however also major sources of reactive oxygen species and when dysfunctional they consume cytosolic ATP. Maintenance of a cohort of healthy mitochondria is therefore crucial for the overall cell fitness. Superfluous or damaged organelles are mainly degraded by mitophagy, a selective process of autophagy. In response to the triggers of mitophagy, mitochondria fragment: this morphological change accomp… Show more

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Cited by 222 publications
(182 citation statements)
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“…The mitochondria are dynamic organelles that migrate throughout the cell, fuse, divide and undergo regulated turnover (Chen and Chan, 2009). iASPP depletion affects the balance of these activities by inhibiting the fusion machinery, leading to the formation of numerous small sphere-shaped mitochondria instead of the tubular and branched organelles observed in normal control cells (Gomes and Scorrano, 2013). A similar phenotype has been reported for the mitochondria of quiescent cells, which have been described as containing numerous morphologically and functionally distinct small spheres (Collins et al, 2002).…”
Section: Discussionmentioning
confidence: 82%
“…The mitochondria are dynamic organelles that migrate throughout the cell, fuse, divide and undergo regulated turnover (Chen and Chan, 2009). iASPP depletion affects the balance of these activities by inhibiting the fusion machinery, leading to the formation of numerous small sphere-shaped mitochondria instead of the tubular and branched organelles observed in normal control cells (Gomes and Scorrano, 2013). A similar phenotype has been reported for the mitochondria of quiescent cells, which have been described as containing numerous morphologically and functionally distinct small spheres (Collins et al, 2002).…”
Section: Discussionmentioning
confidence: 82%
“…Thus, it has been suggested that the fragmentation of dysfunctional mitochondria is a crucial step that precedes mitophagy. 63,64 This phenomenon is modulated by a specific ubiquitin ligase, PARK2/parkin 65 and its interaction with the kinase PINK1 (PTEN-induced putative kinase 1). 66 Especially PINK1 undergoes a voltage dependent cleavage in polarized mitochondria and, following Ψ m collapse, an accumulation of PINK1 is observed, with consequent induction of PARK2 stabilization and initiation of mitochondrion engulfment.…”
Section: Discussionmentioning
confidence: 99%
“…2D and E), although cristae were not readily visible, consistent with the mitochondrial damage described following mitophagy. 24 Electron microscopy images are difficult to quantify, thus to assay the level of mitophagy accurately we used a biochemical method. The delivery of damaged mitochondria to autophagic vacuoles is controlled by the mitochondrial protein PINK1 (PTEN induced putative kinase 1).…”
Section: Mitochondrial Reactive Oxygen Activates the Inflammasome Folmentioning
confidence: 99%