Mitochondrial Metabolic Dysfunction Drives Protein Hyperacylation that Weakens Nucleosomes

Abstract

Though many studies have explored the influence of epigenetics on cellular metabolism, the impact of metabolic changes on chromatin organization is not well understood. This is despite the fact that many metabolites are substrates for epigenetic modifier enzymes known to participate in chromatin reorganization. Various acyl-coenzyme A (CoA) metabolites participate in energy production, including fatty acid oxidation and the citric acid cycle. These me