Mitochondrial Membranes and Mitochondrial Genome: Interactions and Clinical Syndromes

Almannai, Mohammed; Salah, Azza; El‐Hattab, Ayman W.

doi:10.3390/membranes12060625

Cited by 3 publications

(1 citation statement)

References 110 publications

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“…These dangers can be mitigated by keeping an eye out for hyperglycemia throughout pregnancy and maintaining close track of blood sugar levels for the entire nine months [23]. A woman of childbearing age who has diabetes should have preconception counselling, a review of her pharmaceutical regimen (which may involve a higher folic acid dose), intense diabetic treatment, and a carefully crafted conception plan before attempting to conceive [24]. Women with HIP, whether from GDM, undiagnosed DIP, or known diabetes, need the best prenatal care and postpartum support available [25].…”

Section: Management Of Diabetic Mellitusmentioning

confidence: 99%

Combine Therapy of Gallic Acid and Allicin in Management of Diabetes

Kumar¹,

Gardner-Sood²,

Rana³

et al. 2023

J. Res. Appl. Sci. Biotechnol.

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Type 2 diabetes, also known (DM) is a metabolic disorder with a high mortality and disability incidence. The development and activation of oxidative stress (OS) are crucial to the pathogenic development of DM. Pathophysiological evidence suggests that OS contributes to the onset and progression of DM through its association with hyperglycemia, resistance to insulin, and inflammation. It's worth noting that more and more studies are investigating the benefits of natural antioxidants for managing DM. Many different types of culinary and herbal plants contain the antioxidant and anti-inflammatory compounds gallic acid (GA) and allicin, respectively. The synthesis of advanced glycation end products (AGEs) is inhibited, fat is stored less, blood sugar and weight are improved, and the body produces fewer AGEs, according to the study's authors. Inhibition of RAGEs and prevention of AGE activity following treatment with GA and allicin resulted in reduced oxidative stress and enhanced insulin secretion. The goals of this article are to (1) provide evidence that GA and allicin may be effective antihyperglycemic treatments for DM and its complications and (2) provide a comprehensive review of the current state of knowledge regarding studies examining the role of oleic acid in this disease.

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Section: Management Of Diabetic Mellitusmentioning

confidence: 99%

Combine Therapy of Gallic Acid and Allicin in Management of Diabetes

Kumar¹,

Gardner-Sood²,

Rana³

et al. 2023

J. Res. Appl. Sci. Biotechnol.

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Spatiotemporal Distribution and Function of Mitochondria in Oocytes

Kang,

Yan,

Wang

2023

Reprod. Sci.

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Deoxyguanosine kinase deficiency: natural history and liver transplant outcome

Manzoni,

Carli,

Gaignard

et al. 2024

Brain Communications

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Autosomal recessive pathogenetic variants in the DGUOK gene cause deficiency of deoxyguanosine kinase activity and mitochondrial deoxynucleotides pool imbalance, consequently, leading to quantitative and/or qualitative impairment of mitochondrial DNA synthesis. Typically, patients present early-onset liver failure with or without neurological involvement and a clinical course rapidly progressing to death. This is an international multicentre study aiming to provide a retrospective natural history of deoxyguanosine kinase deficient patients. A systematic literature review from January 2001 to June 2023 was conducted. Physicians of research centers or clinicians all around the world caring for previously reported patients were contacted to provide follow-up information or additional clinical, biochemical, histological/histochemical, and molecular genetics data for unreported cases with a confirmed molecular diagnosis of deoxyguanosine kinase deficiency. A cohort of 202 genetically confirmed patients, 36 unreported, and 166 from a systematic literature review, were analyzed. Patients had a neonatal onset (≤ 1 month) in 55.7% of cases, infantile (>1 month and ≤ 1 year) in 32.3%, pediatric (>1 year and ≤18 years) in 2.5%, and adult (>18 years) in 9.5%. Kaplan-Meier analysis showed statistically different survival rates (p < 0.0001) among the four age groups with the highest mortality for neonatal onset. Based on the clinical phenotype, we defined four different clinical subtypes: hepatocerebral (58.8%), isolated hepatopathy (21.9%), hepatomyoencephalopathy (9.6%), and isolated myopathy (9.6%). Muscle involvement was predominant in adult-onset cases whereas liver dysfunction causes morbidity and mortality in early-onset patients with a median survival of less than 1 year. No genotype-phenotype correlation was identified. Liver transplant significantly modified the survival rate in 26 treated patients when compared with untreated. Only six patients had additional mild neurological signs after liver transplant. In conclusion, deoxyguanosine kinase deficiency is a disease spectrum with a prevalent liver and brain tissue-specificity in neonatal and infantile-onset patients and muscle tissue-specificity in adult-onset cases. Our study provides clinical, molecular genetics, and biochemical data for early diagnosis, clinical trial planning, and immediate intervention with liver transplant and/or nucleoside supplementation.

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Mitochondrial Membranes and Mitochondrial Genome: Interactions and Clinical Syndromes

Cited by 3 publications

References 110 publications

Combine Therapy of Gallic Acid and Allicin in Management of Diabetes

Combine Therapy of Gallic Acid and Allicin in Management of Diabetes

Spatiotemporal Distribution and Function of Mitochondria in Oocytes

Deoxyguanosine kinase deficiency: natural history and liver transplant outcome

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