Mitochondrial megaconia and pleioconia in the rat brain as possible adaptive reactions in conditions of lethal radiation and radiomodified lesions

Zabolotskii, N. N.; Onishchenko, L. S.; Galeev, I. Sh.

doi:10.1007/bf02462605

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“…The histological effects of radiation on normal brain tissues have been studied by numerous investigators and the morphological character described has generally been the same, regardless of species or the type of radiation used to induce the damage (17)(18)(19)(20). The majority of these studies used single X-ray (17)(18)(19) rather than fractionated radiotherapy (FRT) (20,21) although fractionated radiation is more commonly used clinically.…”

Section: Introductionmentioning

confidence: 99%

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Radioprotective effects of valproic acid, a histone deacetylase inhibitor, in the rat brain

Zhou

Niu

et al. 2014

Biomedical Reports

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Abstract. Radiotherapy is commonly used in the treatment of brain tumors but can cause significant damage to surrounding normal brain. The radioprotective effects of valproic acid (VPA) on normal tissue in the rat brain were evaluated following irradiation. Male Wistar rats were used in the present study and 48 rats were randomly divided into four groups consisting of 12 rats each. The whole-brain irradiation (WBI) was delivered by X-ray and the rats received the following treatment once a day for 5 days. The control group (sham-exposed group) received sham irradiation plus physiological saline. The VPA group received sham irradiation plus 150 mg VPA/kg. The X-ray group received WBI plus physiological saline. The combined group received WBI plus 150 mg/kg intraperitoneally VPA. A total of 6 months post-irradiation, the rats were sacrificed and the brains were harvested. Cell apoptosis in the cortex was determined by immunohistochemistry 24 h post-irradiation using an antibody for protein caspase-3. Transmission electron microscope (TEM) analyses were used to assess the effects of VPA on the radioprotection of rat normal brain cells 6 months post-irradiation. The weights of the animals in the TEM group measured over the two weeks after the first injection of VPA were also observed. Histological findings demonstrated that apoptosis occurred on the cortex 1 day after treatment, peaking in the X-ray group. The cells of the combined group showed a moderate caspase-3 staining compared to the X-ray group. There was a trend towards a lower body weight of the X-ray group following irradiation compared to either no-irradiation or rats of the combined group, although there was no significant difference in the average weight between the combined group and irradiated rats. Mild swelling of the capillary endothelial cells in the irregular lumen was observed in the combined group, whereas the X-ray group showed a severe structural disorder. In conclusion, VPA supplementation during radiotherapy may be beneficial for radioprotection following WBI by reducing normal brain cell injury.

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Section: Introductionmentioning

confidence: 99%

“…The majority of these studies used single X-ray (17)(18)(19) rather than fractionated radiotherapy (FRT) (20,21) although fractionated radiation is more commonly used clinically. However, radioprotection of VPA in rat brain following moderate-dose FRT is not clearly understood.…”

Section: Introductionmentioning

confidence: 99%

Radioprotective effects of valproic acid, a histone deacetylase inhibitor, in the rat brain

Zhou

Niu

et al. 2014

Biomedical Reports

View full text Add to dashboard Cite

show abstract

Mitochondrial megaconia and pleioconia in the rat brain as possible adaptive reactions in conditions of lethal radiation and radiomodified lesions

Cited by 1 publication

References 1 publication

Radioprotective effects of valproic acid, a histone deacetylase inhibitor, in the rat brain

Radioprotective effects of valproic acid, a histone deacetylase inhibitor, in the rat brain

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