Mitochondrial Involvement in Neurodegenerative Dementia

Bonanni, Laura; Frazzini, Valério; Thomas, Astrid; Onofrj, Marco

doi:10.1002/9781119017127.ch13

Cited by 2 publications

(1 citation statement)

References 92 publications

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“…Mitochondrial-derived H 2 O 2 activates nuclear factor (NF)-κB, leading to a pro-inflammatory shift in endothelial gene profiles (Ungvari et al, 2007). In addition, oxidative stress damages mitochondrial DNA, further contributing to the pathogenesis of dementia (Bonanni et al, 2015; Coppedè and Migliore, 2015). …”

Section: Cerebrovascular Biology and Agingmentioning

confidence: 99%

The impact of cerebrovascular aging on vascular cognitive impairment and dementia

Yang

Sun

et al. 2017

Ageing Research Reviews

147

128

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As human life expectancy rises, the aged population will increase. Aging is accompanied by changes in tissue structure, often resulting in functional decline. For example, aging within blood vessels contributes to a decrease in blood flow to important organs, potentially leading to organ atrophy and loss of function. In the central nervous system, cerebral vascular aging can lead to loss of the integrity of the blood-brain barrier, eventually resulting in cognitive and sensorimotor decline. One of the major of types of cognitive dysfunction due to chronic cerebral hypoperfusion is vascular cognitive impairment and dementia (VCID). In spite of recent progress in clinical and experimental VCID research, our understanding of vascular contributions to the pathogenesis of VCID is still very limited. In this review, we summarize recent findings on VCID, with a focus on vascular age-related pathologies and their contribution to the development of this condition.

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Section: Cerebrovascular Biology and Agingmentioning

confidence: 99%

The impact of cerebrovascular aging on vascular cognitive impairment and dementia

Yang

Sun

et al. 2017

Ageing Research Reviews

147

128

View full text Add to dashboard Cite

show abstract

Relationship between aging-related pulmonary function, cognition, motor function, and activities of daily living in older adults with dementia

Kang

Lee

Park

2022

NRE

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BACKGROUND: The aging process is related to cerebrovascular dysfunction and physiological changes, such as reduced pulmonary function. This ultimately induces cognitive impairment or dementia. OBJECTIVE: This study aimed to determine the relationship between aging-related pulmonary function, cognition, motor function, and activities of daily living (ADLs) in older adults with dementia. METHODS: This cross-sectional study included 69 older adults diagnosed with dementia. Aging-related pulmonary function and cognition were measured using a hand-held spirometer and the Korean version of the Mini-Mental State Examination (MMSE-K), respectively. To assess motor function and ADLs, the Berg Balance Scale (BBS), 10-meter walk test (10-MWT), 6-minute walk test (6-MWT), and modified Barthel index (MBI) were used to measure balance, walking speed, physical functional capacity (or walking tolerance), and ADLs, respectively. All data were analyzed using the Pearson’s product correlation coefficient (r). RESULTS: Forced vital capacity (FVC) and forced expiratory volume in one second (FEV1) as measures of aging-related pulmonary function correlated only with the 6-MWT (FVC: r = 0.483, p = 0.002; FEV1: r = 0.512, p = 0.001). In cognitive function, MMSE-K was associated with BBS (r = 0.283, p = 0.022) and MBI (r = 0.454, p = 0.000). Additionally, there were significant correlations (r = 0.425–0.671, p = 0.000) between all motor function and ADLs measures in older adults with dementia. CONCLUSIONS: Our findings demonstrated that aging-pulmonary function was related to a lower physical functional capacity, and hence, suggested that the reduced pulmonary function were unable to walk for longer distance in older adults with dementia.

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Mitochondrial Involvement in Neurodegenerative Dementia

Cited by 2 publications

References 92 publications

The impact of cerebrovascular aging on vascular cognitive impairment and dementia

The impact of cerebrovascular aging on vascular cognitive impairment and dementia

Relationship between aging-related pulmonary function, cognition, motor function, and activities of daily living in older adults with dementia

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