Abstract:Resistance to chemotherapy represents a bottleneck in clinical cancer treatment and demands urgent solutions. Dysfunction of glucose metabolism including the Warburg effect is an outstanding hallmark of aberrant cancer metabolism which remarkably fosters chemoresistance. Targeting disordered mitochondrial metabolism have paved the road for enhancing chemosensitivity. Human telomerase reverse transcriptase
(hTERT) is tightly associated with cancer initiation and progression. Notably, hTERT can unconventionally … Show more
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