Mitochondrial homeostasis is involved in inhibiting hippocampus neuronal apoptosis during ZSWF ameliorate the cognitive dysfunction of SAMP8 mice

Shi, Xinyuan; Ren, Jiale; Yin, Huajun; Li, Dongna; Song, Lili; Zhang, Yanjun

doi:10.1016/j.jff.2022.105010

Cited by 1 publication

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“…As an upstream target of a series of phosphorylation-dependent adaptive modifiers, AMPK works together with PGC-1α to activate catabolic pathways to produce ATP and suppress energy consumption. It has been reported that cognitive ability could be improved by regulating neuronal mitochondrial homeostasis including mitophagy and mitochondrial biogenesis [ 47 , 48 , 49 ]. Likewise, an interesting finding of the present study was that AMPK expression was upregulated in the hippocampus tissue of mice after WOP treatment.…”

Section: Discussionmentioning

confidence: 99%

Walnut Oligopeptide Delayed Improved Aging-Related Learning and Memory Impairment in SAMP8 Mice

et al. 2022

Nutrients

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Aging-related learning and memory decline are hallmarks of aging and pose a significant health burden. The effects of walnut oligopeptides (WOPs) on learning and memory were evaluated in this study. Sixty SAMP8 mice were randomly divided into four groups (15 mice/group), including one SAMP8 age-control group and three WOP-treated groups. SAMR1 mice (n = 15) that show a normal senescence rate were used as controls. The SAMP8 and SAMR1 controls were administered ordinary sterilized water, while the WOP-intervention groups were administered 110, 220, and 440 mg/kg·bw of WOPs in water, respectively. The whole intervention period was six months. The remaining 15 SAMP8 (4-month-old) mice were used as the young control group. The results showed that WOPs significantly improved the decline in aging-related learning/memory ability. WOPs significantly increased the expression of BDNF and PSD95 and decreased the level of APP and Aβ1-42 in the brain. The mechanism of action may be related to an increase in the activity of antioxidant enzymes (SOD and GSH-Px), a reduction in the expression of inflammatory factors (TNF-α and IL-1β) in the brain and a reduction in oxidative stress injury (MDA). Furthermore, the expression of AMPK, SIRT-1, and PGC-1α was upregulated and the mitochondrial DNA content was increased in brain. These results indicated that WOPs improved aging-related learning and memory impairment. WOP supplementation may be a potential and effective method for the elderly.

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Section: Discussionmentioning

confidence: 99%

Walnut Oligopeptide Delayed Improved Aging-Related Learning and Memory Impairment in SAMP8 Mice

et al. 2022

Nutrients

View full text Add to dashboard Cite

show abstract

Mitochondrial homeostasis is involved in inhibiting hippocampus neuronal apoptosis during ZSWF ameliorate the cognitive dysfunction of SAMP8 mice

Cited by 1 publication

References 20 publications

Walnut Oligopeptide Delayed Improved Aging-Related Learning and Memory Impairment in SAMP8 Mice

Walnut Oligopeptide Delayed Improved Aging-Related Learning and Memory Impairment in SAMP8 Mice

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