The Molecular Biology of Schizosaccharomyces Pombe 2004
DOI: 10.1007/978-3-662-10360-9_28
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Mitochondrial Genetics in a Petite-Negative Yeast

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Cited by 3 publications
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“…It is shown that, as in budding yeast (22), the NTD of Cdc17 is suf®cient to target GFP to both the nucleus and mitochondria, consistent with a model in which the use of alternate in-frame start codons results in the production of distinct nuclear and mitochondrial forms of the Cdc17 protein. Mitochondrial function is known to be essential for ®ssion yeast viability (26). Here it is shown that co-expression of nuclear and mitochondrial forms in vivo restores full viability to cdc17D cells, whereas expression of either protein alone does not.…”
Section: Introductionmentioning
confidence: 82%
“…It is shown that, as in budding yeast (22), the NTD of Cdc17 is suf®cient to target GFP to both the nucleus and mitochondria, consistent with a model in which the use of alternate in-frame start codons results in the production of distinct nuclear and mitochondrial forms of the Cdc17 protein. Mitochondrial function is known to be essential for ®ssion yeast viability (26). Here it is shown that co-expression of nuclear and mitochondrial forms in vivo restores full viability to cdc17D cells, whereas expression of either protein alone does not.…”
Section: Introductionmentioning
confidence: 82%
“…Nevertheless in fission yeast, the Crabtree effect is less pronounced than in S. cerevisiae since the inhibition of oxygen consumption by glucose is smaller; in other words S. pombe maintains a higher respiration rate in the presence of glucose [22] . Consistently, it is hard to isolate respiratory-deficient cells ( petite ) in S. pombe [23] , [24] , while these mutants occur spontaneously in S. cerevisiae . Furthermore, S. pombe differs from S. cerevisiae because of its lack of glyoxylate cycle that makes it inefficient in ethanol consumption as carbon source [25] , [26] .…”
Section: Introductionmentioning
confidence: 99%
“…Lastly, naturally occurring strains of Sz. pombe are petite ‐negative, unable to survive without mtDNA (Schäfer and Wolf, ). It remains unknown what the effect of Sp Mdm31 loss on stability of mtDNA in Sz.…”
Section: Introductionmentioning
confidence: 99%