Mitochondrial functions of polymelanosomes

Woert, Melvin H. Van; Nicholson, Alex; Cotzias, George C.

doi:10.1016/0010-406x(67)90610-x

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Selected Tissues From Animals Fed1

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1985

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Cited by 10 publications

(2 citation statements)

References 13 publications

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“…The melanosomes studied had high manga-nese uptakes, rivaling those of mitochondria (9,15). These considerations agree with our findings in view of the contrast in pigmentation between pallid and black mice.…”

Section: Selected Tissues From Animals Fedsupporting

confidence: 90%

A Mutation Influencing the Transportation of Manganese, L-Dopa, and L-Tryptophan

Cotzias

Tang

Miller

et al. 1972

Science

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Section: Selected Tissues From Animals Fedsupporting

confidence: 90%

A Mutation Influencing the Transportation of Manganese, L-Dopa, and L-Tryptophan

Cotzias

Tang

Miller

et al. 1972

Science

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“…1967;Potts & Au 1976;Lyden et al 1983Lyden et al & 1984. Manganese has affinity for melanin in vivo as well (Van Woert et a/. 1967;Lyden et a/.…”

mentioning

confidence: 99%

Autoradiography of l–Methyl–4–phenyl–l,2,3,6–tetrahydropyridine (MPTP): Uptake in the Monoaminergic Pathways and in Melanin Containing Tissues

Lydén

Bondesson

Larsson

et al. 1985

Acta Pharmacologica et Toxicologica

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A recently discovered neurotoxic compound, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, has been found to cause a parkinsonian-like syndrome in man and monkey, but not in laboratory animals such as rat, mouse and guinea pig. MPTP seems to selectively destroy the melanin containing dopaminergic cells in pars compacta of substantia nigra. Lower mammalian species do not have melanin in these cells, which indicates that the presence of neuromelanin may be of importance for the development of MPTP-induced lesions. By means of whole-body autoradiography of 3H-MPTP in mice, accumulation and retention was observed in the dopaminergic pathways, in locus caeruleus and in structures in the medulla oblongata and spinal cord. A high uptake was also seen in melanin-containing tissues such as in the eyes of pigmented mice. MPTP has earlier been found to have high affinity in vitro for dopamine melanin, which is similar to the pigment in substantia nigra. The typical features of the MPTP-induced neurotoxicity with destruction of pigmented nerve cells and development of parkinsonism may be to to accumulation and retention of MPTP and its metabolites in these cells. In species with pigmented nerve cells, such as man and monkey, the accumulation may be much more pronounced because of the melanin affinity of MPTP and its metabolites.

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Metabolic Modification of Some Neurologic Disorders

Cotzias¹

1969

JAMA

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Mitochondrial functions of polymelanosomes

Cited by 10 publications

References 13 publications

A Mutation Influencing the Transportation of Manganese, L-Dopa, and L-Tryptophan

A Mutation Influencing the Transportation of Manganese, L-Dopa, and L-Tryptophan

Autoradiography of l–Methyl–4–phenyl–l,2,3,6–tetrahydropyridine (MPTP): Uptake in the Monoaminergic Pathways and in Melanin Containing Tissues

Metabolic Modification of Some Neurologic Disorders

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