Mitochondrial Functionality Is Regulated by Alkylphospholipids in Human Colon Cancer Cells
Margalida Torrens-Mas,
Alejandro Collado-Solé,
Alberto Sola-Leyva
et al.
Abstract:Alkylphospholipids (APLs) have been studied as anticancer drugs that interfere with biological membranes without targeting DNA. Although their mechanism of action is not fully elucidated yet, it is known that they disrupt the intracellular trafficking of cholesterol and its metabolism. Here, we analyzed whether APLs could also interfere with mitochondrial function. For this purpose, we used HT29 colorectal cancer cells, derived from a primary tumor, and SW620 colorectal cancer cells, derived from a metastasis … Show more
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