Mitochondrial function in selected major depressive disorder patients

Gardner, Ann; Johansson, A.; Wibom, Rolf; Nennesmo, Inger; Döbeln, Ulrika von; Hagenfeldt, Lars; Hällström, Tore

doi:10.1016/s0924-9338(02)80556-9

Cited by 2 publications

(2 citation statements)

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“…In addition, FA treatment significantly increased the gene expression levels of Hk and Pc , the rate‐limiting enzymes of the glycolysis and TCA cycle. It was previously reported that there were significant loss of mitochondrial ATP production and reduction in mitochondrial enzyme ratio in the patients with major depression . This present study shows that FA treatment increased the ATP level in the limbic area of the brain of ICR mice.…”

Section: Discussionsupporting

confidence: 74%

Antidepressant‐Like Effect of Ferulic Acid via Promotion of Energy Metabolism Activity

Sasaki

Iwata

Ferdousi

et al. 2019

Molecular Nutrition Food Res

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Scope Ferulic acid (FA), a natural phenolic phytochemical abundantly present in whole grains, herbs, and dried fruits, exhibits anti‐inflammatory, antioxidant, and neuroprotective effects. In the present study, the antidepressant‐like effects of FA in male ICR mice using tail suspension test (TST) are investigated and its molecular mechanisms are explored. Methods and Results Oral administration of FA at a dose of 5 mg kg–1 for 7 days significantly reduces immobility of mice compared to vehicle‐administered control group. Microarray and real‐time PCR analyses reveal that FA upregulates the expression of several genes associated with cell survival and proliferation, energy metabolism, and dopamine synthesis in mice limbic system of brain. Interestingly, it is found that FA, unlike antidepressant drug bupropion, strongly promotes energy metabolism. Additionally, FA increases catecholamine (dopamine and noradrenaline), brain‐derived neurotrophic factor, and ATP levels, and decreases glycogen levels in the limbic system of the mice brain. Conclusion The research provides the first evidence that FA enhances energy production, which can be the underlying mechanism of the antidepressant‐like effects of FA observed in this study.

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Section: Discussionsupporting

confidence: 74%

Antidepressant‐Like Effect of Ferulic Acid via Promotion of Energy Metabolism Activity

Sasaki

Iwata

Ferdousi

et al. 2019

Molecular Nutrition Food Res

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“…However, MDD is increasingly viewed as an illness of the mind as well as the body (8,9). Literature already reports mitochondria-related effects in fibroblasts (1,9), muscle- (10), peripheral mononuclear blood cells (11), and platelets (12,13) of depressed patients, suggesting that mitochondria-related pathomechanisms associated with MDD can be identified and studied in neuronal and also in peripheral non-neuronal cells.…”

Section: Introductionmentioning

confidence: 99%

Induced neural progenitor cells and iPS-neurons from major depressive disorder patients show altered bioenergetics and electrophysiological properties

Triebelhorn

Kuffner

Cardon

et al. 2021

Preprint

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BACKGROUND: The molecular pathomechanisms of major depressive disorder (MDD) are still not completely understood. Here, we follow the hypothesis, that mitochondrial dysfunction which is inevitably associated with bioenergetic misbalance is a risk factor that contributes to the susceptibility of an individual to develop MDD. MDD can be regarded as disease of the mind as well as of the body. Thus, we focused on mitochondrial and cellular function in reprogrammed neural cells from MDD patients and healthy controls. METHODS: We investigated molecular mechanisms related to mitochondrial and cellular functions in induced neuronal progenitor cells (NPCs) as well as in neurons, which were reprogrammed from fibroblasts of depressed patients and non-depressed controls, respectively. RESULTS: We found significantly lower basal respiration rates and a less hyperpolarized mitochondrial membrane potential in NPCs derived from MDD patients. These findings are in line with our earlier observations in patient-derived fibroblasts (1). Furthermore, we differentiated MDD and control NPCs into iPS-neurons and analyzed their passive biophysical and active electrophysiological properties. Interestingly, MDD patient-derived iPS-neurons showed significantly lower membrane capacitance, a more depolarized membrane potential, and increased spontaneous electrical activity. This is the first report showing functional differences in MDD patient-derived and control NPCs and iPS-neurons. CONCLUSION: Our findings indicate that functional differences evident in fibroblasts from depressed patients are also present after reprogramming and differentiation to induced-NPCs and iPS-neurons and might be associated with the aetiology of major depressive disorder.

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Mitochondrial function in selected major depressive disorder patients

Cited by 2 publications

References 0 publications

Antidepressant‐Like Effect of Ferulic Acid via Promotion of Energy Metabolism Activity

Antidepressant‐Like Effect of Ferulic Acid via Promotion of Energy Metabolism Activity

Induced neural progenitor cells and iPS-neurons from major depressive disorder patients show altered bioenergetics and electrophysiological properties

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