Mitochondrial function and nutrient sensing pathways in ageing: enhancing longevity through dietary interventions

Tomtheelnganbee, Elangbam; Sah, Puja; Sharma, Ramesh

doi:10.1007/s10522-022-09978-7

Cited by 7 publications

(3 citation statements)

References 259 publications

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“…Existing research has confirmed that there are some similarities in physiological characteristics and structure between gut microbiome and mitochondria, both of which jointly regulate host metabolism and longevity (Tomtheelnganbee et al 2022 ; Ghosh et al 2022 ). We hypothesize that there may be a potential cross-talk within the gut microbiome and the host mitochondria because existing studies have provided ample supporting evidence for this interaction mechanism.…”

Section: The Interaction Between Gut Microbial Metabolites and Mitoch...mentioning

confidence: 99%

The potential mechanism of gut microbiota-microbial metabolites-mitochondrial axis in progression of diabetic kidney disease

Ma,

Zhang,

et al. 2023

Mol Med

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Diabetic kidney disease (DKD), has become the main cause of end-stage renal disease (ESRD) worldwide. Lately, it has been shown that the onset and advancement of DKD are linked to imbalances of gut microbiota and the abnormal generation of microbial metabolites. Similarly, a body of recent evidence revealed that biological alterations of mitochondria ranging from mitochondrial dysfunction and morphology can also exert significant effects on the occurrence of DKD. Based on the prevailing theory of endosymbiosis, it is believed that human mitochondria originated from microorganisms and share comparable biological characteristics with the microbiota found in the gut. Recent research has shown a strong correlation between the gut microbiome and mitochondrial function in the occurrence and development of metabolic disorders. The gut microbiome’s metabolites may play a vital role in this communication. However, the relationship between the gut microbiome and mitochondrial function in the development of DKD is not yet fully understood, and the role of microbial metabolites is still unclear. Recent studies are highlighted in this review to examine the possible mechanism of the gut microbiota-microbial metabolites-mitochondrial axis in the progression of DKD and the new therapeutic approaches for preventing or reducing DKD based on this biological axis in the future.

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Section: The Interaction Between Gut Microbial Metabolites and Mitoch...mentioning

confidence: 99%

The potential mechanism of gut microbiota-microbial metabolites-mitochondrial axis in progression of diabetic kidney disease

Ma,

Zhang,

et al. 2023

Mol Med

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“…Conversely, the downregulated GPR19 data cohorts were more strongly associated with ‘Interleukin signaling’, ‘mTOR signaling’, ‘IGF-1 signaling’ and ‘Nuclear Laminopathies’. All of these diverse functions strongly converge with respect to the pathomechanisms linked to pathological aging (DNA damage—[ 73 ]; Cholesterol regulation [ 188 , 189 , 190 ]; stem cell management [ 191 , 192 ]; UPR [ 193 , 194 ]; mTOR signaling [ 195 , 196 ]; IGF-1 signaling [ 197 , 198 ]; laminopathies [ 199 , 200 ]).…”

Section: Functional Gpr19 Molecular Signaturesmentioning

confidence: 99%

Intersection of the Orphan G Protein-Coupled Receptor, GPR19, with the Aging Process

Maudsley

Walter

Schrauwen

et al. 2022

IJMS

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G protein-coupled receptors (GPCRs) represent one of the most functionally diverse classes of transmembrane proteins. GPCRs and their associated signaling systems have been linked to nearly every physiological process. They also constitute nearly 40% of the current pharmacopeia as direct targets of remedial therapies. Hence, their place as a functional nexus in the interface between physiological and pathophysiological processes suggests that GPCRs may play a central role in the generation of nearly all types of human disease. Perhaps one mechanism through which GPCRs can mediate this pivotal function is through the control of the molecular aging process. It is now appreciated that, indeed, many human disorders/diseases are induced by GPCR signaling processes linked to pathological aging. Here we discuss one such novel member of the GPCR family, GPR19, that may represent an important new target for novel remedial strategies for the aging process. The molecular signaling pathways (metabolic control, circadian rhythm regulation and stress responsiveness) associated with this recently characterized receptor suggest an important role in aging-related disease etiology.

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“…This special issue of Biogerontology on dietary interventions for ageing and longevity brings together review articles and original research papers reporting some exciting and novel data. The review article by Tomtheelnganbee et al (2022) discusses how CR/ DR interventions, and CR-mimetics help in alleviating the two major hallmarks of ageing i.e. mitochondrial dysfunction and declining nutrient sensing pathways in ageing organisms.…”

mentioning

confidence: 99%

Editorial note for special issue on ‘dietary interventions for healthy ageing and longevity’

Kaur

Sharma

2022

Biogerontology

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Mitochondrial function and nutrient sensing pathways in ageing: enhancing longevity through dietary interventions

Cited by 7 publications

References 259 publications

The potential mechanism of gut microbiota-microbial metabolites-mitochondrial axis in progression of diabetic kidney disease

The potential mechanism of gut microbiota-microbial metabolites-mitochondrial axis in progression of diabetic kidney disease

Intersection of the Orphan G Protein-Coupled Receptor, GPR19, with the Aging Process

Editorial note for special issue on ‘dietary interventions for healthy ageing and longevity’

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