Mitochondrial function and cerebral blood flow responses under unilateral carotid occlusion in rats

Early monitoring of cerebral hypoperfusion in rats by laser speckle imaging and functional photoacoustic microscopy

“…Some studies reported that CBF velocity decreased to minimum in several seconds and recovered to baseline within several minutes in transient cerebral hypoperfusion in rats using laser Doppler Flowmetry (LDF). 13,14 Other studies showed that hemoglobal oxygen saturation (SO 2 ) or hemoglobin oxygenation decreased in several seconds immediately after the CCA occlusion using near-infrared spectroscopy (NIRS) or diffuse optical tomography (DOT). [15][16][17] These aforementioned techniques have the potential to detect cerebral hypoperfusion at the early stage by monitoring rapid hemodynamic response or oxygen metabolism changes.…”

Assessment of Brain Metabolic Score (BMS) In Vivo Based on Mitochondrial Activity in Neuropathology

“…In those medical environments the need for objective approach for decision making processes is very important as discussed previously [183][184][185][186][187][188][189][190][191][192][193][194][195][196][197][198][199]. In order to develop the BMS we used the multiparametric monitoring system described in detail in Figure 15 and the development of the score appeared in our publication .…”

“…For the physiological interpretation of the changes in NADH measured in vivo, it was necessary to move from a single parameter monitoring system to the multiparametric monitoring approach) MPA). 8,191,192,194,195,197,198,200,201 As described in Figure 2B the redox state of NADH represent also the balance between oxygen demand and supply. Therefore, the multiparametric monitoring system results could provide better understanding of the pathophysiological processes developed.…”