2010
DOI: 10.1016/j.jneumeth.2010.01.022
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Mitochondrial function and cerebral blood flow variable responses to middle cerebral artery occlusion

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Cited by 10 publications
(3 citation statements)
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“…Ischemia-induced cerebral injury leads to cerebral infarction and, ultimately, brain dysfunction (16,17). In the present study, it was observed that ischemia exacerbated neurological deficits and increased cerebral infarction.…”
Section: Discussionsupporting
confidence: 54%
“…Ischemia-induced cerebral injury leads to cerebral infarction and, ultimately, brain dysfunction (16,17). In the present study, it was observed that ischemia exacerbated neurological deficits and increased cerebral infarction.…”
Section: Discussionsupporting
confidence: 54%
“…Variability in infarct volume or functional outcome attributable to these concerns could decrease reliability of this model. There are methods for confirmation of ischemia during intraluminal MCAO including positron emission tomography (Martin et al, 2012), magnetic resonance imaging (Bihel et al, 2010), laser speckle imaging (Akamatsu et al, 2012), hydrogen clearance (Laing et al, 1993), and fluorometric measurement of mitochondrial NADH (Livnat et al, 2010). While these monitors have important roles in certain experimental paradigms, LDF has been advocated because the LDF system is compact, easy to use, and does not require complex surgery or radionuclide use.…”
Section: Discussionmentioning
confidence: 99%
“…The impact of ischemia -to some degree-can be described by neurological deficits using neurological severit y assessment scores (Bederson, Pitts et al 1986, Garcia, Wagner et al 1995 or behavioral tests (Schallert 2006, Encarnacion, Horie et al 2011). However, one major drawback of the intraluminal method is the occurrence of model-immanent confounding pathologies and complications: incomplete MCAO (Zausinger, Baethmann et al 2002), early, late or missing reperfusion (Livnat, Barbiro-Michaely et al 2010), and subarachnoid hemorrhage (Longa, Weinstein et al 1989, Schmid-Elsaesser, Zausinger et al 1998. Particularly with regard to time-and labour-consuming long-term experiments a reliable and prompt surveillance of the desired vessel occlusion excluding any secondary damages is of great importance because MRI is not always available or feasible and the additional lesions at the time of sacrifice may no longer be recognizable and therefore results may be biased.…”
Section: Introductionmentioning
confidence: 99%