Mitochondrial fission proteins in peripheral blood lymphocytes are potential biomarkers for Alzheimer’s disease

Wang, S.; Song, Juexian; Tan, Meng-Shan; Albers, Kathryn M.; Jia, Jianping

doi:10.1111/j.1468-1331.2012.03670.x

Cited by 61 publications

(43 citation statements)

References 31 publications

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“…An association between dementia and mitochondrial function has also been reported. For instance, an increased number of mtDNA mutations and abnormal mitochondrial morphologic changes were found in blood [34] and brain [35] samples of Alzheimer disease patients as compared to those of control subjects. Quantitatively, our previous study showed a positive relationship between mtDNA copy number and cognitive function in non-demented elderly adults consistent with our present results [36].…”

Section: Discussionmentioning

confidence: 99%

Combined Impact of Telomere Length and Mitochondrial DNA Copy Number on Cognitive Function in Community-Dwelling Very Old Adults

Jeeyon

Kim²,

Lee³

2017

Dement Geriatr Cogn Disord

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Background: This study was conducted to investigate the combined impact of telomere length and mitochondrial DNA (mtDNA) copy number on cognitive function in community-dwelling very old adults. Methods: In total, 186 subjects over 75 years participated in this study. Cognitive function was assessed using the Korean Mini-Mental State Examination, and leukocyte telomere length and mtDNA copy number were measured using real-time polymerase chain reaction methods. Results: Both the fourth quartile of telomere length and mtDNA copy number were associated with cognitive dysfunction with an adjusted odds ratio of 0.23 (95% confidence interval (CI), 0.10-0.75) and 0.18 (95% CI, 0.03-0.54), respectively. Participants in the high telomere length/high mtDNA copy number group were more likely to have cognitive dysfunction than participants in the low telomere/low mtDNA copy number group with an adjusted odds ratio of 0.19 (95% CI, 0.07-0.58). Conclusion: Our results collectively suggest that the combination of telomere length and mtDNA copy number may be useful for monitoring cognitive decline in older adults.

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Section: Discussionmentioning

confidence: 99%

Combined Impact of Telomere Length and Mitochondrial DNA Copy Number on Cognitive Function in Community-Dwelling Very Old Adults

Jeeyon

Kim²,

Lee³

2017

Dement Geriatr Cogn Disord

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“…In support of a pathological role for S-nitrolyation of Drp1, Drp1 is apparently S-nitrosylated aberrantly because it is found at high levels in postmortem human AD brains but not in control brains [190–191], as well as in peripheral blood lymphocytes of AD but not control patients [194]. …”

Section: Drp1 and Cdk5 In Alzheimer’s Diseasementioning

confidence: 99%

Multiple faces of dynamin-related protein 1 and its role in Alzheimer's disease pathogenesis

Kandimalla¹,

Reddy

2016

Biochimica et Biophysica Acta (BBA) - Molecular Basis of Diseas

124

104

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Mitochondria play a large role in neuronal function by constantly providing energy, particularly at synapses. Recent studies suggest that amyloid beta (Aβ) and phosphorylated tau interact with the mitochondrial fission protein, dynamin-related protein 1 (Drp1), causing excessive fragmentation of mitochondria and leading to abnormal mitochondrial dynamics and synaptic degeneration in Alzheimer’s disease (AD) neurons. Recent research also revealed Aβ-induced and phosphorylated tau-induced changes in mitochondria, particularly affecting mitochondrial shape, size, distribution and axonal transport in AD neurons. These changes affect mitochondrial health and, in turn, could affect synaptic function and neuronal damage and ultimately leading to memory loss and cognitive impairment in patients with AD. This article highlights recent findings in the role of Drp1 in AD pathogenesis. This article also highlights Drp1 and its relationships to glycogen synthase kinase 3, cyclin-dependent kinase 5, p53, and microRNAs in AD pathogenesis.

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“…However, there is controversy over DLP1 expression: reduced DLP1 expression in AD brain was reported by Wang et al and by Bossy et al [9, 57], but not by Manczak et al who actually found increased DLP1 in AD [11]. Reduced DLP1 expression is also demonstrated in fibroblasts and lymphocytes from AD patients [10, 58]. Given that the majority of DLP1 in mammalian cells is cytosolic and mitochondrial recruitment of DLP1 represents a critical step during mitochondrial fission [18], mitochondrial DLP1 serves as a better indicator for mitochondrial fission.…”

Section: Introductionmentioning

confidence: 99%

Abnormal Mitochondrial Dynamics in the Pathogenesis of Alzheimer's Disease

Zhu

Perry

Smith

et al. 2012

JAD

164

130

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Mitochondrial dysfunction is one of the most early and prominent features in vulnerable neurons in the brain of Alzheimer's disease (AD) patients. Recent studies suggest that mitochondria are highly dynamic organelles characterized by a delicate balance of fission and fusion, a concept that has revolutionized our basic understanding of the regulation of mitochondrial structure and function which has far-reaching significance in studies of health and disease. Tremendous progress has been made in studying changes in mitochondrial dynamics in AD brain and models and the potential underlying mechanisms. This review highlights the recent work demonstrating abnormal mitochondrial dynamics and distribution in AD models and discusses how these abnormalities may contribute to various aspects of mitochondrial dysfunction and the pathogenesis of AD.

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Mitochondrial fission proteins in peripheral blood lymphocytes are potential biomarkers for Alzheimer’s disease

Abstract: Altered mitochondrial fission proteins Drp1, SNO-Drp1, and Fis1 in PBL were relatively sensitive and specific in identifying AD patients and could be serving as a biomarker in the procedure of diagnosis.

Cited by 61 publications

References 31 publications

Combined Impact of Telomere Length and Mitochondrial DNA Copy Number on Cognitive Function in Community-Dwelling Very Old Adults

Combined Impact of Telomere Length and Mitochondrial DNA Copy Number on Cognitive Function in Community-Dwelling Very Old Adults

Multiple faces of dynamin-related protein 1 and its role in Alzheimer's disease pathogenesis

Abnormal Mitochondrial Dynamics in the Pathogenesis of Alzheimer's Disease

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