Mitochondrial encephalopathy, lactic acidosis, and stroke-like episodes diagnosed after metformin-triggered stroke-like episodes

Murakami, Keishu; Sakamoto, Ken; Ishiguchi, Hiroshi; Ito, Hidefumi

doi:10.1016/j.jstrokecerebrovasdis.2023.107080

Cited by 5 publications

(1 citation statement)

References 9 publications

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“…The authors suggest considering Dipeptidyl Peptidase IV (DPP-IV) inhibitors, Sodium-glucose Cotransporter-2 (SGLT2) inhibitors and glucagon-like peptide-1 (GLP-1) receptor agonists as first-line agents. This study adds to four case reports of patients with m.3243A>G who had neurologic symptoms seemingly fomented by metformin initiation [29–32]. However, the association between metformin and neurologic symptoms remains statistically insignificant, and causality has not been established.…”

Section: Endocrinopathies In Primary Mitochondrial Diseasesmentioning

confidence: 77%

Endocrine features of primary mitochondrial diseases

Romo,

Gold,

Walker

2023

Current Opinion in Endocrinology, Diabetes &Amp; Obesity

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Purpose of review Primary mitochondrial diseases are one of the most prevalent groups of multisystem genetic disorders. Endocrinopathies associated with mitochondrial diseases may have clinical features that are distinct from the more common forms. We provide an overview of mitochondrial disorder genetics and phenotypes, focusing on recent studies regarding identification and treatment of associated endocrinopathies. Recent findings Known endocrine phenotypes of mitochondrial disorders continue to expand, and now include growth hormone deficiency, hypogonadism, precocious puberty, hypoparathyroidism, hypo- and hyperthyroidism, diabetes, and adrenal insufficiency. Recent studies suggest several genotype-phenotype correlations, including those related to nuclear variants. Diagnosis is important, as special considerations should be made in the management of endocrinopathies in mitochondrial patients. Finally, new mitochondrial replacement strategies may soon be available for women interested in preventing mitochondrial disease transmission to offspring. Summary Patients with multiple endocrinopathies or atypical endocrinopathies should be evaluated for primary mitochondrial disease, as a diagnosis may impact management of these individuals.

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Section: Endocrinopathies In Primary Mitochondrial Diseasesmentioning

confidence: 77%