Mitochondrial dysfunctions, oxidative stress and neuroinflammation as therapeutic targets for neurodegenerative diseases: An update on current advances and impediments

Rehman, Muneeb U.; Sehar, Nouroz; Dar, Nawab John; Khan, Andleeb; Arafah, Azher; Rashid, Summya; Rashid, Shahzada Mudasir; Ganaie, Majid Ahmad

doi:10.1016/j.neubiorev.2022.104961

Cited by 49 publications

(29 citation statements)

References 330 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is assumed that NM (which is absent in the SN of rats) could reduce the toxicity of iron. The importance of mitochondrial function and impairment for ROS generation and the pathophysiology of PD has been extensivly reviewed in several excellent recent publications (for review: Rehman et al 2023 ) and has also been linked to important steps in neuroinflammation (Han and Le 2023 ; Magalhães, Cardoso 2023 ).…”

Section: Introductionmentioning

confidence: 99%

The heterogeneity of Parkinson’s disease

et al. 2023

View full text Add to dashboard Cite

The heterogeneity of Parkinson’s disease (PD), i.e. the various clinical phenotypes, pathological findings, genetic predispositions and probably also the various implicated pathophysiological pathways pose a major challenge for future research projects and therapeutic trail design. We outline several pathophysiological concepts, pathways and mechanisms, including the presumed roles of α-synuclein misfolding and aggregation, Lewy bodies, oxidative stress, iron and melanin, deficient autophagy processes, insulin and incretin signaling, T-cell autoimmunity, the gut–brain axis and the evidence that microbial (viral) agents may induce molecular hallmarks of neurodegeneration. The hypothesis is discussed, whether PD might indeed be triggered by exogenous (infectious) agents in susceptible individuals upon entry via the olfactory bulb (brain first) or the gut (body-first), which would support the idea that disease mechanisms may change over time. The unresolved heterogeneity of PD may have contributed to the failure of past clinical trials, which attempted to slow the course of PD. We thus conclude that PD patients need personalized therapeutic approaches tailored to specific phenomenological and etiologic subtypes of disease.

show abstract

Section: Introductionmentioning

confidence: 99%

The heterogeneity of Parkinson’s disease

et al. 2023

View full text Add to dashboard Cite

show abstract

“…One of the factors causing brain biochemical disturbance is oxidative stress (Bilgiç et al, 2023). Abundant scientific findings are conforming that the oxidative stress and neuroinflammation are involved in the induction and progression of neurodegenerative diseases such as AD, Parkinson's disease, and neuropsychiatric disorders including anxiety and depression (Rehman et al, 2022). Medicinal plants extract and its ingredients have been understood to be as modulators of oxidative status and inflammation in the brain (Anaeigoudari, 2022b).…”

Section: Methodsmentioning

confidence: 99%

A review of therapeutic impacts of saffron (Crocus sativus L.) and its constituents

Anaeigoudari,

Kheirkhah‐Vakilabad

2023

Physiological Reports

View full text Add to dashboard Cite

Application of herbal medicines in the treatment of diseases is in the center of attention of medical scientific societies. Saffron (Cricus sativus L.) is a medicinal plant belonging to the Iridaceae family with different therapeutic properties. The outcomes of human and animal experiments indicate that therapeutic impacts of saffron and its constituents, crocin, crocetin, and safranal, mainly are mediated via inhibiting the inflammatory reactions and scavenging free radicals. It has been suggested that saffron and crocin extracted from it also up‐regulate the expression of sirtuin 1 (SIRT1) and nuclear factor erythroid 2‐related factor 2 (Nrf2), down‐regulate nuclear factor kappa B (NF‐κB) signaling pathway and untimely improve the body organs dysfunction. Inhibition of inducible nitric oxide synthase and cyclooxygenase‐2 (COX2) also is attributed to crocin. The current review narrates the therapeutic effects of saffron and its constituents on various body systems through looking for the scientific databases including Web of Science, PubMed, Scopus, and Google Scholar from the beginning of 2010 until the end of 2022.

show abstract

“…It is also characterized by an advanced motor disability, including chorea [ 111 ]. Enough evidence suggests that the mutation may cause an alteration in mitochondrial trafficking, an increase in oxidative stress, dyshomeostasis in intracellular calcium content, an alteration in bioenergetics, and an alteration in a respiratory mitochondrial chain [ 112 , 113 , 114 , 115 ]. Huntington’s disease, PD, and Alzheimer’s disease are three neurodegenerative diseases that have 37 common genes and about 40% of whose products act at the mitochondrial level [ 116 ].…”

Section: Role Of Mitochondria In Neurodegenerative Diseasementioning

confidence: 99%

Mitochondrial Bioenergy in Neurodegenerative Disease: Huntington and Parkinson

Tassone

Meringolo

Ponterio

et al. 2023

IJMS

View full text Add to dashboard Cite

Strong evidence suggests a correlation between degeneration and mitochondrial deficiency. Typical cases of degeneration can be observed in physiological phenomena (i.e., ageing) as well as in neurological neurodegenerative diseases and cancer. All these pathologies have the dyshomeostasis of mitochondrial bioenergy as a common denominator. Neurodegenerative diseases show bioenergetic imbalances in their pathogenesis or progression. Huntington’s chorea and Parkinson’s disease are both neurodegenerative diseases, but while Huntington’s disease is genetic and progressive with early manifestation and severe penetrance, Parkinson’s disease is a pathology with multifactorial aspects. Indeed, there are different types of Parkinson/Parkinsonism. Many forms are early-onset diseases linked to gene mutations, while others could be idiopathic, appear in young adults, or be post-injury senescence conditions. Although Huntington’s is defined as a hyperkinetic disorder, Parkinson’s is a hypokinetic disorder. However, they both share a lot of similarities, such as neuronal excitability, the loss of striatal function, psychiatric comorbidity, etc. In this review, we will describe the start and development of both diseases in relation to mitochondrial dysfunction. These dysfunctions act on energy metabolism and reduce the vitality of neurons in many different brain areas.

show abstract

Mitochondrial dysfunctions, oxidative stress and neuroinflammation as therapeutic targets for neurodegenerative diseases: An update on current advances and impediments

Cited by 49 publications

References 330 publications

The heterogeneity of Parkinson’s disease

The heterogeneity of Parkinson’s disease

A review of therapeutic impacts of saffron (Crocus sativus L.) and its constituents

Mitochondrial Bioenergy in Neurodegenerative Disease: Huntington and Parkinson

Contact Info

Product

Resources

About