Mitochondrial dysfunction in mouse livers depleted of iron chaperone PCBP1

Jadhav, Shyamalagauri; Protchenko, Olga; Li, Fengmin; Baratz, Ethan; Shakoury‐Elizeh, Minoo; Maschek, J. Alan; Cox, James E.; Philpott, Caroline C.

doi:10.1016/j.freeradbiomed.2021.08.232

Cited by 22 publications

(14 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Deletion of PCBP1 releases labile iron, which leads to mitochondrial damage, lipid peroxidation and ferroptosis. Vitamin E, alone or together with coenzyme Q, removed iron-dependent oxidative stress and prevented ferroptosis in hepatocytes (213,214).…”

Section: Vitamin E and Regulated Necrosismentioning

confidence: 99%

Crosstalk between regulated necrosis and micronutrition, bridged by reactive oxygen species

Zhang

Liu²,

Dai³

et al. 2022

Front. Nutr.

View full text Add to dashboard Cite

The discovery of regulated necrosis revitalizes the understanding of necrosis from a passive and accidental cell death to a highly coordinated and genetically regulated cell death routine. Since the emergence of RIPK1 (receptor-interacting protein kinase 1)-RIPK3-MLKL (mixed lineage kinase domain-like) axis-mediated necroptosis, various other forms of regulated necrosis, including ferroptosis and pyroptosis, have been described, which enrich the understanding of pathophysiological nature of diseases and provide novel therapeutics. Micronutrients, vitamins, and minerals, position centrally in metabolism, which are required to maintain cellular homeostasis and functions. A steady supply of micronutrients benefits health, whereas either deficiency or excessive amounts of micronutrients are considered harmful and clinically associated with certain diseases, such as cardiovascular disease and neurodegenerative disease. Recent advance reveals that micronutrients are actively involved in the signaling pathways of regulated necrosis. For example, iron-mediated oxidative stress leads to lipid peroxidation, which triggers ferroptotic cell death in cancer cells. In this review, we illustrate the crosstalk between micronutrients and regulated necrosis, and unravel the important roles of micronutrients in the process of regulated necrosis. Meanwhile, we analyze the perspective mechanism of each micronutrient in regulated necrosis, with a particular focus on reactive oxygen species (ROS).

show abstract

Section: Vitamin E and Regulated Necrosismentioning

confidence: 99%

Crosstalk between regulated necrosis and micronutrition, bridged by reactive oxygen species

Zhang

Liu²,

Dai³

et al. 2022

Front. Nutr.

View full text Add to dashboard Cite

show abstract

“…However, these resources are scarce and incomplete. Only recently (2021)(2022) have iron-related canonical pathways been added to the curated database from QIAGEN Ingenuity Pathway Analysis (IPA, Qiagen) (https://www. qiagen.com/ingenuity).…”

Section: Bioinformatics Approaches Tailored For the Analysis Of Iron ...mentioning

confidence: 99%

“…PCBP1-deficient livers exhibited depletion of mitochondrial lipids cardiolipin and coenzyme Q. These lipid changes contributed to mitochondrial damage and manifested in multiple signs of mitochondrial dysfunction in PCBP1-depleted livers ( Jadhav et al, 2021 ). Diets supplemented with antioxidants vitamin E or coenzyme Q partially prevented the development of steatosis and liver damage, and coenzyme Q was required to prevent mitochondrial dysfunction.…”

Section: Detoxification Of Iron In Livermentioning

confidence: 99%

Iron-tracking strategies: Chaperones capture iron in the cytosolic labile iron pool

Philpott

Protchenko²,

Wang³

et al. 2023

Front. Mol. Biosci.

Self Cite

View full text Add to dashboard Cite

Cells express hundreds of iron-dependent enzymes that rely on the iron cofactors heme, iron-sulfur clusters, and mono-or di-nuclear iron centers for activity. Cells require systems for both the assembly and the distribution of iron cofactors to their cognate enzymes. Proteins involved in the binding and trafficking of iron ions in the cytosol, called cytosolic iron chaperones, have been identified and characterized in mammalian cells. The first identified iron chaperone, poly C-binding protein 1 (PCBP1), has also been studied in mice using genetic models of conditional deletion in tissues specialized for iron handling. Studies of iron trafficking in mouse tissues have necessitated the development of new approaches, which have revealed new roles for PCBP1 in the management of cytosolic iron. These approaches can be applied to investigate use of other nutrient metals in mammals.

show abstract

“…PCBP1 plays a critical role in systemic iron homeostasis, as hepatocyte-specific PCBP1 knockout (KO) mice show low hepatic ferritin levels, mitochondrial dysfunction, and ROS-mediated lipid peroxidation [ 32 , 33 ]. The direct involvement of PCBP in intestinal ferritin regulation is not clear.…”

Section: Cytosolic Chaperones For Delivering Iron Into Ferritinmentioning

confidence: 99%

The Role of Ferritin in Health and Disease: Recent Advances and Understandings

et al. 2022

View full text Add to dashboard Cite

Systemic iron homeostasis needs to be tightly controlled, as both deficiency and excess iron cause major global health concerns, such as iron deficiency anemia, hemochromatosis, etc. In mammals, sufficient dietary acquisition is critical for fulfilling the systemic iron requirement. New questions are emerging about whether and how cellular iron transport pathways integrate with the iron storage mechanism. Ferritin is the intracellular iron storage protein that stores surplus iron after all the cellular needs are fulfilled and releases it in the face of an acute demand. Currently, there is a surge in interest in ferritin research after the discovery of novel pathways like ferritinophagy and ferroptosis. This review emphasizes the most recent ferritin-related discoveries and their impact on systemic iron regulation.

show abstract

Mitochondrial dysfunction in mouse livers depleted of iron chaperone PCBP1

Cited by 22 publications

References 37 publications

Crosstalk between regulated necrosis and micronutrition, bridged by reactive oxygen species

Crosstalk between regulated necrosis and micronutrition, bridged by reactive oxygen species

Iron-tracking strategies: Chaperones capture iron in the cytosolic labile iron pool

The Role of Ferritin in Health and Disease: Recent Advances and Understandings

Contact Info

Product

Resources

About