Mitochondrial Dysfunction in Metabolic Syndrome and Asthma

Mabalirajan, Ulaganathan; Ghosh, Balaram

doi:10.1155/2013/340476

Cited by 33 publications

(38 citation statements)

References 132 publications

(159 reference statements)

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“…The role of fetuin-A in metabolic syndrome and its components Metabolic syndrome, currently affecting 10-30% of the world population, is a clustering of increased waist circumference, dyslipidemia, impaired glucose metabolism and hypertension 14,25 . A close association between fetuin-A concentration and MetS has been shown in cross sectional studies 8,14,26 .…”

Section: Fetuin-a and Inflammationmentioning

confidence: 99%

Fetuin-A (AHSG) and its usefulness in clinical practice. Review of the literature

et al. 2015

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Section: Fetuin-a and Inflammationmentioning

confidence: 99%

Fetuin-A (AHSG) and its usefulness in clinical practice. Review of the literature

et al. 2015

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“…Exposure to air particle pollutants are associated with many human diseases and conditions, including asthma, obesity, hypertension, and cardiovascular disease (CVD), all of which are related to mitochondrial dysfunction [69]. The size of airborne particles varies from 1 nm to 1 μm in diameter [70].…”

Section: Particulate Mattermentioning

confidence: 99%

Mitochondrial Epigenetics and Environmental Exposure

Lambertini

Byun

2016

Curr Envir Health Rpt

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The rising toll of chronic and debilitating diseases brought about by the exposure to an ever expanding number of environmental pollutants and socio-economic factors is calling for action. The understanding of the molecular mechanisms behind the effects of environmental exposures can lead to the development of biomarkers that can support the public health fields of both early diagnosis and intervention to limit the burden of environmental diseases. The study of mitochondrial epigenetics carries high hopes to provide important biomarkers of exposure and disease. Mitochondria are in fact on the frontline of the cellular response to the environment. Modifications of the epigenetic factors regulating the mitochondrial activity are emerging as informative tools that can effectively report on the effects of the environment on the phenotype. Here, we will discuss the emerging field of mitochondrial epigenetics. This review describes the main epigenetic phenomena that modify the activity of the mitochondrial DNA including DNA methylation, long and short non-coding RNAs. We will discuss the unique pattern of mitochondrial DNA methylation, describe the challenges of correctly measuring it, and report on the existing studies that have analysed the correlation between environmental exposures and mitochondrial DNA methylation. Finally, we provide a brief account of the therapeutic approaches targeting mitochondria currently under consideration.

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“…[243-245] for recent reviews). But the impact of mitochondrial complex I malfunction on obesity is not fully understood despite the tight link of decreased complex I activity with obesity [246-248].…”

Section: Representative Applications Of Shotgun Lipidomics In Biolmentioning

confidence: 99%

Novel advances in shotgun lipidomics for biology and medicine

Wang

Han

et al. 2016

Progress in Lipid Research

220

186

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The field of lipidomics, as coined in 2003, has made profound advances and been rapidly expanded. The mass spectrometry-based strategies of this analytical methodology-oriented research discipline for lipid analysis are largely fallen into three categories: direct infusion-based shotgun lipidomics, liquid chromatography-mass spectrometry-based platforms, and matrix-assisted laser desorption/ionization mass spectrometry-based approaches (particularly in imagining lipid distribution in tissues or cells). This review focuses on shotgun lipidomics. After briefly introducing its fundamentals, the major materials of this article cover its recent advances. These include the novel methods of lipid extraction, novel shotgun lipidomics strategies for identification and quantification of previously hardly accessible lipid classes and molecular species including isomers, and novel tools for processing and interpretation of lipidomics data. Representative applications of advanced shotgun lipidomics for biological and biomedical research are also presented in this review. We believe that with these novel advances in shotgun lipidomics, this approach for lipid analysis should become more comprehensive and high throughput, thereby greatly accelerating the lipidomics field to substantiate the aberrant lipid metabolism, signaling, trafficking, and homeostasis under pathological conditions and their underpinning biochemical mechanisms.

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Mitochondrial Dysfunction in Metabolic Syndrome and Asthma

Cited by 33 publications

References 132 publications

Fetuin-A (AHSG) and its usefulness in clinical practice. Review of the literature

Fetuin-A (AHSG) and its usefulness in clinical practice. Review of the literature

Mitochondrial Epigenetics and Environmental Exposure

Novel advances in shotgun lipidomics for biology and medicine

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