Mitochondrial dysfunction and risk of cancer

Lund, Marie; Melbye, Mads; Díaz, Lars Jorge; Dunø, Morten; Wohlfahrt, Jan; Vissing, John

doi:10.1038/bjc.2015.66

Cited by 19 publications

(15 citation statements)

References 29 publications

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“…A recent study of a cohort including 311 individuals with mitochondrial dysfunction (90% maternally inherited mtDNA mutation) has not shown an increased risk of cancer compared with the general population. However, these results do not contradict the hypothesis that secondary mtDNA alterations are formed during tumorigenesis, which can play an essential role in the further malignant transformation [275–277]. …”

Section: Oxidative Dna Damagementioning

confidence: 53%

Mitochondrial dysfunction and oxidative stress in aging and cancer

et al. 2016

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Aging and cancer are the most important issues to research. The population in the world is growing older, and the incidence of cancer increases with age. There is no doubt about the linkage between aging and cancer. However, the molecular mechanisms underlying this association are still unknown. Several lines of evidence suggest that the oxidative stress as a cause and/or consequence of the mitochondrial dysfunction is one of the main drivers of these processes. Increasing ROS levels and products of the oxidative stress, which occur in aging and age-related disorders, were also found in cancer. This review focuses on the similarities between ageing-associated and cancer-associated oxidative stress and mitochondrial dysfunction as their common phenotype.

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Section: Oxidative Dna Damagementioning

confidence: 53%

Mitochondrial dysfunction and oxidative stress in aging and cancer

et al. 2016

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“…Somatic mtDNA mutations are commonly found in cancer (Singh, 2004). Individuals with mitochondrial disease do not appear to be at increased risk of cancer (Lund et al, 2015); however, epidemiologic studies of cancer have provided mixed evidence for a role of inherited mtDNA variation and cancer risk. An increased risk of hematopoietic cancer was reported in individuals with the M7B2 haplogroup in the Japanese population in one previous study (OR=2.46, 95% CI 1.06, 5.73) (Singh and Kulawiec, 2009).…”

Section: Discussionmentioning

confidence: 99%

Association between mitochondrial DNA haplogroup and myelodysplastic syndromes

Poynter

Richardson

Langer

et al. 2016

Genes Chromosomes & Cancer

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Polymorphisms in mitochondrial DNA (mtDNA) are used to group individuals into haplogroups reflecting human global migration and are associated with multiple diseases, including cancer. Here, we evaluate the association between mtDNA haplogroup and risk of myelodysplastic syndromes (MDS). Cases were identified by the Minnesota Cancer Surveillance System (MCSS). Controls were identified through the Minnesota State driver’s license/identification card list. Because haplogroup frequencies vary by race and ethnicity, we restricted analyses to non-Hispanic whites. We genotyped 15 mtSNPs that capture common European mitochondrial haplogroup variation. We used SAS v.9.3 (SAS Institute, Cary, NC) to calculate odds ratios (OR) and 95% confidence intervals (CI) overall and stratified by MDS subtype and IPSS-R risk category. We were able to classify 215 cases with confirmed MDS and 522 controls into one of the 11 common European haplogroups. Due to small sample sizes in some subgroups, we combined mt haplogroups into larger bins based on the haplogroup evolutionary tree, including HV (H+V), JT (J+T), IWX (I+W+X), UK (U+K), and Z for comparisons of cases and controls. Using haplogroup HV as the reference group, we found a statistically significant association between haplogroup JT and MDS (OR=0.58, 95% CI 0.36, 0.92, P=0.02). No statistically significant heterogeneity was observed in subgroup analyses. In this population-based study of MDS, we observed an association between mtDNA haplogroup JT and risk of MDS. While previously published studies provide biological plausibility for the observed association, further studies of the relationship between mtDNA variation and MDS are warranted in larger sample sizes.

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“…Somatic mtDNA mutations are commonly found in cancer (Singh, 2004). Individuals with mitochondrial disease do not appear to be at increased risk of cancer (Lund et al, 2015); however, epidemiologic studies of cancer have provided mixed evidence for a role of inherited mtDNA variation and cancer risk. An increased risk of hematopoietic cancer was reported in individuals with the M7B2 haplogroup in the Japanese population in one previous study (OR 5 2.46, 95% CI 1.06, 5.73) (Singh and Kulawiec, 2009).…”

Section: Discussionmentioning

confidence: 99%

Association Between Mitochondrial DNA Haplogroup and Myelodysplastic Syndromes

Poynter

Richardson

Langer

et al. 2015

Blood

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Polymorphisms in mitochondrial DNA (mtDNA) are used to group individuals into haplogroups reflecting human global migration and are associated with multiple diseases, including cancer. Here, we evaluate the association between mtDNA haplogroup and risk of myelodysplastic syndromes (MDS). Cases were identified by the Minnesota Cancer Surveillance System. Controls were identified through the Minnesota State driver's license/identification card list. Because haplogroup frequencies vary by race and ethnicity, we restricted analyses to non-Hispanic whites. We genotyped 15 mtSNPs that capture common European mitochondrial haplogroup variation. We used SAS v.9.3 (SAS Institute, Cary, NC) to calculate odds ratios (OR) and 95% confidence intervals (CI) overall and stratified by MDS subtype and IPSS-R risk category. We were able to classify 215 cases with confirmed MDS and 522 controls into one of the 11 common European haplogroups. Due to small sample sizes in some subgroups, we combined mt haplogroups into larger bins based on the haplogroup evolutionary tree, including HV (H 1 V), JT (J 1 T), IWX (I 1 W 1 X), UK (U 1 K), and Z for comparisons of cases and controls. Using haplogroup HV as the reference group, we found a statistically significant association between haplogroup JT and MDS (OR 5 0.58, 95% CI 0.36, 0.92, P 5 0.02). No statistically significant heterogeneity was observed in subgroup analyses. In this population-based study of MDS, we observed an association between mtDNA haplogroup JT and risk of MDS. While previously published studies provide biological plausibility for the observed association, further studies of the relationship between mtDNA variation and MDS are warranted in larger sample sizes.

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Mitochondrial dysfunction and risk of cancer

Cited by 19 publications

References 29 publications

Mitochondrial dysfunction and oxidative stress in aging and cancer

Mitochondrial dysfunction and oxidative stress in aging and cancer

Association between mitochondrial DNA haplogroup and myelodysplastic syndromes

Association Between Mitochondrial DNA Haplogroup and Myelodysplastic Syndromes

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