Mitochondrial dysfunction and oxidative stress in corneal disease

Vallabh, Neeru A.; Romano, Vito; Willoughby, Colin E.

doi:10.1016/j.mito.2017.05.009

Cited by 78 publications

(57 citation statements)

References 143 publications

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“…Mutations in OPA1 and MFN2 genes cause autosomal dominant optic atrophy (DOA); mutations in WFS1 and CISD2 can cause Wolfram syndrome, while Leber's hereditary optic neuropathy (LHON) is associated with mutations in mitochondrial ND1, ND4, and ND6 genes [61,62]. However, many other eye diseases have been linked to mitochondrial dysfunction occurring secondary to other conditions including glaucoma and other optic neuropathies, age-related macular degeneration, diabetic retinopathy, and retinitis pigmentosa [63][64][65][66][67][68][69][70][71].…”

Section: Mitochondrial Intercellular Transfer Via Tnts and Implicatiomentioning

confidence: 99%

Tunneling Nanotubes and the Eye: Intercellular Communication and Implications for Ocular Health and Disease

Chinnery

Keller

2020

BioMed Research International

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Cellular communication is an essential process for the development and maintenance of all tissues including the eye. Recently, a new method of cellular communication has been described, which relies on formation of tubules, called tunneling nanotubes (TNTs). These structures connect the cytoplasm of adjacent cells and allow the direct transport of cellular cargo between cells without the need for secretion into the extracellular milieu. TNTs may be an important mechanism for signaling between cells that reside long distances from each other or for cells in aqueous environments, where diffusion-based signaling is challenging. Given the wide range of cargoes transported, such as lysosomes, endosomes, mitochondria, viruses, and miRNAs, TNTs may play a role in normal homeostatic processes in the eye as well as function in ocular disease. This review will describe TNT cellular communication in ocular cell cultures and the mammalian eye in vivo, the role of TNTs in mitochondrial transport with an emphasis on mitochondrial eye diseases, and molecules involved in TNT biogenesis and their function in eyes, and finally, we will describe TNT formation in inflammation, cancer, and stem cells, focusing on pathological processes of particular interest to vision scientists.

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Section: Mitochondrial Intercellular Transfer Via Tnts and Implicatiomentioning

confidence: 99%

Tunneling Nanotubes and the Eye: Intercellular Communication and Implications for Ocular Health and Disease

Chinnery

Keller

2020

BioMed Research International

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“…Ocular Surface and Corneal Diseases. Due to its structure and function, the ocular surface and especially the cornea are constantly exposed to high oxygen tension, chemical burns, UV radiation (especially UVB), pathogenic microorganisms, or even urban air pollution [17,18], which are the source of ROS and OS. The cornea is particularly susceptible to OS due to an imbalance between ROS and cellular antioxidant capacity.…”

Section: Oxidative Stress and Nrf2 In Ocular Diseasesmentioning

confidence: 99%

Potential Protective and Therapeutic Roles of the Nrf2 Pathway in Ocular Diseases: An Update

Wang

Zhao

Zhang

et al. 2020

Oxidative Medicine and Cellular Longevity

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Nuclear factor- (erythroid-derived 2-) like 2 (Nrf2) is a regulator of many processes of life, and it plays an important role in antioxidant, anti-inflammatory, and antifibrotic responses and in cancer. This review is focused on the potential mechanism of Nrf2 in the occurrence and development of ocular diseases. Also, several Nrf2 inducers, including noncoding RNAs and exogenous compounds, which control the expression of Nrf2 through different pathways, are discussed in ocular disease models and ocular cells, protecting them from dysfunctional changes. Therefore, Nrf2 might be a potential target of protecting ocular cells from various stresses and preventing ocular diseases.

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“…While visible light must be able to transit through the cornea and into the eye itself, UV light penetration must be minimized to prevent damage to the retina. To protect the eye from UV light radiation, the cornea mass‐produces an isoenzyme of aldehyde dehydrogenase (ALDH3) that acts as a filter to minimize penetration into the eye (Vallabh et al, ).…”

Section: Pathogenesismentioning

confidence: 99%

Keratoconus at a Molecular Level: A Review

Volatier

Figueiredo

Connon

2019

The Anatomical Record

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Keratoconus is the most common ectatic disease of the cornea. The disease is usually detected between ages 15 and 25. Incidence is estimated at one out of every 2000 individuals, with some specific ethnic groups being more at risk. Keratoconus manifests itself as a progressive stromal thinning and deformation of the corneal tissue into a conical shape. The etiology of keratoconus is uncertain, although several studies have associated the disease to environmental factors, behavioral conditions and certain genetic disorders. In an effort to better understand how the corneal stroma becomes compromised, multiple experiments have been conducted over the last few years looking at the cells themselves and the factors they produce. The secretion pathways and levels of inflammatory molecules, growth factors, digestive enzymes, and apoptotic factors are all relevant to keratoconus. This review describes the current knowledge of keratoconic pathological signaling pathways within the cornea that may help future developments in disease prevention, treatment and modeling.

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Mitochondrial dysfunction and oxidative stress in corneal disease

Cited by 78 publications

References 143 publications

Tunneling Nanotubes and the Eye: Intercellular Communication and Implications for Ocular Health and Disease

Tunneling Nanotubes and the Eye: Intercellular Communication and Implications for Ocular Health and Disease

Potential Protective and Therapeutic Roles of the Nrf2 Pathway in Ocular Diseases: An Update

Keratoconus at a Molecular Level: A Review

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