Mitochondrial Dysfunction and Disturbed Coherence: Gate to Cancer

Abstract

Continuous energy supply, a necessary condition for life, excites a state far from thermodynamic equilibrium, in particular coherent electric polar vibrations depending on water ordering in the cell. Disturbances in oxidative metabolism and coherence are a central issue in cancer development. Oxidative metabolism may be impaired by decreased pyruvate transfer to the mitochondrial matrix, either by parasitic consumption and/or mitochondrial dysfunction. This can in turn lead to disturbance in water molecules’ ordering, diminished power, and coherence of the electromagnetic field. In tumors with the Warburg (reverse Warburg) effect, mitochondrial dysfunction affects cancer cells (fibroblasts associated with cancer cells), and the electromagnetic field generated by microtubules in cancer cells has low power (high power due to transport of energy-rich metabolites from fibroblasts), disturbed coherence, and a shifted frequency spectrum according to changed power. Therapeutic strategies restoring mitochondrial function may trigger apoptosis in treated cells; yet, before this step is performed, induction (inhibition) of pyruvate dehydrogenase kinases (phosphatases) may restore the cancer state. In tumor tissues with the reverse Warburg effect, Caveolin-1 levels should be restored and the transport of energy-rich metabolites interrupted to cancer cells. In both cancer phenotypes, achieving permanently reversed mitochondrial dysfunction with metabolic-modulating drugs may be an effective, specific anti-cancer strategy.

The quantum mitochondrion and optimal health

“…Certainly, it has been long known that electrics fields affect cell function and shape: calcium has a strong effect on the electrical energy transfer and transistor-like properties of microtubules [70]. It has also been suggested that differences in mitochondrial function in cancer alter electric fields, in particular, affecting water order and coherence–which could be involved in the disease process [71]. Cancer is clearly associated with changes in mitochondrial dynamics and ultrastructure [72].…”

Models of Distribution of Electric Field of Primary Cilia as Monopole Antennas

“…In the vicinity of a single mitochondrion, the intensity of the electric field reduces almost linearly as a function of distance. Values of 540 kV/m for the electric field were measured at a distance of 2 µm from mitochondrion [5,6]. About 40% of the input chemical energy of the mitochondrion are converted into ATP and GTP, with the remaining 60% liberated from mitochondria as photons and heat [4].…”

“…The oscillations generate EMF. The strong electrostatic field surrounding the mitochondria can move microtubule oscillations into highly nonlinear region [5]. Mitochondrial dysfunction in cancer cells (Warburg effect) or in fibroblasts associated with cancer cells (reverse Warburg effect) results in decreased or increased power of the EMF generated, respectively [5,7].…”

Untitled

“…protein) would be between 2-3 nm, which equates to about 7 to 10 layers of water molecules (Cameron and Fullerton 2014). Pokorný et al, based on work of others including (Stebbings and Hunt 1982), describe "empty layers" measuring 5-20 nm around microtubules with the ability to exclude solutes (Pokorný et al 2015). Collectively these studies imply that so-called "non-bulk" water may "jacket" all biologically-active molecules and membranes, including intracellular organelles, mitochondria, DNA and RNA.…”