Mitochondrial dynamics regulators: implications for therapeutic intervention in cancer

Kumar, Sanjay; Ashraf, Rahail; C.K., Aparna

doi:10.1007/s10565-021-09662-5

Cited by 29 publications

(16 citation statements)

References 220 publications

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“…In particular, in different cancer diseases [ 41 ], emerging evidence highlights that deregulation of mitochondrial dynamics is involved in several aspects of cancer development, such as cancer metastasis, drug resistance and cancer stem cell survival. Thus, mitochondrial shaping proteins and their regulators have been proposed as potential targets for therapeutic approaches [ 41 , 42 ].…”

Section: Mitochondrial Overview In Cancermentioning

confidence: 99%

Ovarian Cancer: A Landscape of Mitochondria with Emphasis on Mitochondrial Dynamics

Rasmo

Cormio

et al. 2023

IJMS

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Ovarian cancer (OC) represents the main cause of death from gynecological malignancies in western countries. Altered cellular and mitochondrial metabolism are considered hallmarks in cancer disease. Several mitochondrial aspects have been found altered in OC, such as the oxidative phosphorylation system, oxidative stress and mitochondrial dynamics. Mitochondrial dynamics includes cristae remodeling, fusion, and fission processes forming a dynamic mitochondrial network. Alteration of mitochondrial dynamics is associated with metabolic change in tumour development and, in particular, the mitochondrial shaping proteins appear also to be responsible for the chemosensitivity and/or chemoresistance in OC. In this review a focus on the mitochondrial dynamics in OC cells is presented.

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Section: Mitochondrial Overview In Cancermentioning

confidence: 99%

Ovarian Cancer: A Landscape of Mitochondria with Emphasis on Mitochondrial Dynamics

Rasmo

Cormio

et al. 2023

IJMS

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“…The relationship between apoptosis and autophagy is complex and difficult to clarify. The process of apoptosis is often accompanied by autophagy ( 40 ). Most evidence show that autophagy is the protective mechanism of cell initiation.…”

Section: Potential Molecular Mechanism Of Mitochondrial Dysfunction I...mentioning

confidence: 99%

Effect of Fluoride on Cytotoxicity Involved in Mitochondrial Dysfunction: A Review of Mechanism

Wei

Ali

et al. 2022

Front. Vet. Sci.

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Fluoride is commonly found in the soil and water environment and may act as chronic poison. A large amount of fluoride deposition causes serious harm to the ecological environment and human health. Mitochondrial dysfunction is a shared feature of fluorosis, and numerous studies reported this phenomenon in different model systems. More and more evidence shows that the functions of mitochondria play an extremely influential role in the organs and tissues after fluorosis. Fluoride invades into cells and mainly damages mitochondria, resulting in decreased activity of mitochondrial related enzymes, weakening of protein expression, damage of respiratory chain, excessive fission, disturbance of fusion, disorder of calcium regulation, resulting in the decrease of intracellular ATP and the accumulation of Reactive oxygen species. At the same time, the decrease of mitochondrial membrane potential leads to the release of Cyt c, causing a series of caspase cascade reactions and resulting in apoptosis. This article mainly reviews the mechanism of cytotoxicity related to mitochondrial dysfunction after fluorosis. A series of mitochondrial dysfunction caused by fluorosis, such as mitochondrial dynamics, mitochondrial Reactive oxygen species, mitochondrial fission, mitochondrial respiratory chain, mitochondrial autophagy apoptosis, mitochondrial fusion disturbance, mitochondrial calcium regulation are emphasized, and the mechanism of the effect of fluoride on cytotoxicity related to mitochondrial dysfunction are further explored.

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“…Tumorigenesis and metastatic dissemination rely on mitochondrial bioenergetics mainly through respiration, signaling and dynamics (Kumar et al, 2021). Mitochondria must sense the surrounding environment in order to adapt to cellular metabolic demands.…”

Section: Mitochondrial Metabolism In Melanomamentioning

confidence: 99%

Connecting Metabolic Rewiring With Phenotype Switching in Melanoma

Falletta

Goding

Vivas-García

2022

Front. Cell Dev. Biol.

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Melanoma is a complex and aggressive cancer type that contains different cell subpopulations displaying distinct phenotypes within the same tumor. Metabolic reprogramming, a hallmark of cell transformation, is essential for melanoma cells to adopt different phenotypic states necessary for adaptation to changes arising from a dynamic milieu and oncogenic mutations. Increasing evidence demonstrates how melanoma cells can exhibit distinct metabolic profiles depending on their specific phenotype, allowing adaptation to hostile microenvironmental conditions, such as hypoxia or nutrient depletion. For instance, increased glucose consumption and lipid anabolism are associated with proliferation, while a dependency on exogenous fatty acids and an oxidative state are linked to invasion and metastatic dissemination. How these different metabolic dependencies are integrated with specific cell phenotypes is poorly understood and little is known about metabolic changes underpinning melanoma metastasis. Recent evidence suggests that metabolic rewiring engaging transitions to invasion and metastatic progression may be dependent on several factors, such as specific oncogenic programs or lineage-restricted mechanisms controlling cell metabolism, intra-tumor microenvironmental cues and anatomical location of metastasis. In this review we highlight how the main molecular events supporting melanoma metabolic rewiring and phenotype-switching are parallel and interconnected events that dictate tumor progression and metastatic dissemination through interplay with the tumor microenvironment.

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Mitochondrial dynamics regulators: implications for therapeutic intervention in cancer

Cited by 29 publications

References 220 publications

Ovarian Cancer: A Landscape of Mitochondria with Emphasis on Mitochondrial Dynamics

Ovarian Cancer: A Landscape of Mitochondria with Emphasis on Mitochondrial Dynamics

Effect of Fluoride on Cytotoxicity Involved in Mitochondrial Dysfunction: A Review of Mechanism

Connecting Metabolic Rewiring With Phenotype Switching in Melanoma

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