Mitochondrial DNA Polymorphism and Determination of Effects on Reproductive Trait in Pigs

Yen, N. T.; Lin, Chih‐Sheng; Ju, C. C.; Wang, S. C.; Huang, Mu-Chiou

doi:10.1111/j.1439-0531.2006.00797.x

Cited by 13 publications

(8 citation statements)

References 31 publications

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“…In cattle, there have been associations with calving rates [ 8 ], meat [ 9 ] and milk [ 10 ] quality traits, embryo production efficiency [ 11 , 12 ], and body weight in, for example, American bison carrying cattle mtDNA [ 13 ]. In pigs, there are associations with body weight [ 14 ] and meat quality [ 15 ]. Furthermore, associations have been reported with reproductive capacity and litter size in pigs [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

The association of mitochondrial DNA haplotypes and phenotypic traits in pigs

John

Tsai

2018

BMC Genet

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BackgroundThe mitochondrial genome (mtDNA) is an emerging determiner of phenotypic traits and disease. mtDNA is inherited in a strict maternal fashion from the population of mitochondria present in the egg at fertilisation. Individuals are assigned to mtDNA haplotypes and those with sequences that cluster closely have common origins and their migration patterns can be mapped. Previously, we identified five mtDNA haplotypes in the commercial breeding lines of Australian pigs, which defined their common origins, and showed how these mtDNA haplotypes influenced litter size and reproductive function in terms of egg and embryo quality and fertilisation efficiency.ResultsWe have determined whether mtDNA haplotypes influence other phenotypic traits. These include fat density; muscle depth; fat to leanness ratios; lifetime daily gain; teat quality; muscle score; front and rear leg assessments; percentage offspring weaned; weaning to oestrus intervals; gilt age at selection; and gestational length. In all, we assessed 5687 pigs of which 2762 were females and 2925 were males. We assessed all animals together and then by gender. We further assessed by gender based on whether a sire had joined with females from only one haplotype or from more than one haplotype. We determined that fat density, muscle depth, fat to leanness ratios, lifetime daily gain and teat quality were influenced by mtDNA haplotype and that there were gender specific effects on teat quality.ConclusionsOur data illustrate that mtDNA haplotypes are associated with a number of important phenotypic traits indicative of economic breeding values in breeding pigs with gender-specific differences. Interestingly, there are ‘trade offs’ whereby some mtDNA haplotypes perform better for one selection criterion, such as muscle depth, but less so for another, for example teat quality, indicating that pig mtDNA haplotypes are afforded an advantage in one respect but a disadvantage in another.Electronic supplementary materialThe online version of this article (10.1186/s12863-018-0629-4) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

The association of mitochondrial DNA haplotypes and phenotypic traits in pigs

John

Tsai

2018

BMC Genet

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“…However, this is quite a relaxed assumption and, in order to obtain more accurate estimates, quantitative cytoplasmic genetic models have to be further extended to the association analyses of the mitogenome variation (polymorphism), from D-loop mitochondrial DNA (mtDNA) to complete mitogenome, with production traits. Good examples are provided in studies related to cattle (Boettcher et al, 1996a;Mezzadra et al, 2005), poultry (Li et al, 1998;Zhao et al, 2015), swine (Yen et al, 2007;Fernández et al, 2008;Yu et al, 2015, Tsai et al, 2016 and sheep (Chen et al, 2017) populations, as well as to humans (Ruiz-Pesini et al, 2000;Liu et al, 2012), where the association of certain mitogenome polymorphisms with quantitative traits have been analysed.…”

Section: Introductionmentioning

confidence: 99%

Analysis of the impact of cytoplasmic and mitochondrial inheritance on litter size and carcass in rabbits

et al. 2018

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<p>The effects of mitogenome variation on economically important traits have been reported in a number of domestic animal species. In this study, the first of its kind on rabbits, we have performed the estimation of the contribution of cytoplasmic and D-loop mitochondrial DNA (mtDNA) sequence effects on the litter size and carcass traits in three Pannon rabbit breeds (Pannon Ka, Pannon Large and Pannon White). The observed effects of both estimates, coming from cytoplasmic or D-loop mtDNA variation, were negligible. The most likely explanation for the results obtained is the lack of mitogenome polymorphism in all three populations, as suggested from the analysis performed on the D-loop mtDNA sequence, here assigned to the two most frequent rabbit haplotypes. The extent of potential benefits of the introduction, or alteration, of mitogenome variation in rabbit breeding remains an open question for future research.</p>

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“…Mitochondrial genome codes 13 polypeptides, 2 rRNAs and 22 tRNAs [1]. Since the first report of mitochondrial DNA (mtDNA) effect on milk production traits in dairy cattle [2], mtDNA effects on various economic traits have been widely studied in livestock, including pigs [3, 4], dairy cattle [5, 6], beef cattle [7, 8], sheep [9, 10] and chickens [11, 12]. Litter size is one of the vital economic traits for animal breeding and production, which has been studied for decades.…”

Section: Introductionmentioning

confidence: 99%

Mitochondrial DNA T7719G in tRNA-Lys gene affects litter size in Small-tailed Han sheep

Chen

Wang

Xiang

et al. 2017

J Animal Sci Biotechnol

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BackgroundIn farm animals, mitochondrial DNA (mtDNA) effect on economic performance remains hot-topic for breeding and genetic selection. Here, 53 maternal lineages of Small-tailed Han sheep were used to investigate the association of mitochondrial DNA variations and the lambing litter size.ResultsSequence sweeping of the mitochondrial coding regions discovered 31 non-synonymous mutations, and the association study revealed that T7719G in mtDNA tRNA-Lys gene was associated with litter size (P < 0.05), manifesting 0.29 lambs per litter between the G and T carriers. Furthermore, using the mixed linear model, we assayed the potential association of the ovine litter size and haplogroups and multiple-level mtDNA haplotypes, including general haplotypes, assembled haplotypes of electron transport chain contained sequences (H-ETC), mitochondrial respiratory complex contained sequences (H-MRC) and mitochondrial genes (H-gene, including polypeptide-coding genes, rRNA genes and tRNA genes). The strategy for assembled mitochondrial haplotypes was proposed for the first time in mtDNA association analyses on economic traits, although none of the significant relations could be concluded (P > 0.05). In addition, the nuclear major gene BMPR1B was significantly correlated with litter size in the flock (P < 0.05), however, did not interact with mtDNA T7719G mutation (P > 0.05).ConclusionsOur results highlight mutations of ovine mitochondrial coding genes, suggesting T7719G in tRNA-Lys gene be a potentially useful marker for selection of sheep litter size.Electronic supplementary materialThe online version of this article (doi:10.1186/s40104-017-0160-x) contains supplementary material, which is available to authorized users.

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Mitochondrial DNA Polymorphism and Determination of Effects on Reproductive Trait in Pigs

Cited by 13 publications

References 31 publications

The association of mitochondrial DNA haplotypes and phenotypic traits in pigs

The association of mitochondrial DNA haplotypes and phenotypic traits in pigs

Analysis of the impact of cytoplasmic and mitochondrial inheritance on litter size and carcass in rabbits

Mitochondrial DNA T7719G in tRNA-Lys gene affects litter size in Small-tailed Han sheep

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