Mitochondrial DNA Mutations in Individuals Occupationally Exposed to Ionizing Radiation

Wilding, Craig S.; Cadwell, Kevin; Tawn, E. Janet; Relton, Caroline; Taylor, Geoffrey A.; Chinnery, Patrick F.; Turnbull, Douglass M.

doi:10.1667/rr3494.1

Cited by 19 publications

(13 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…NAA synthesis was shut down and this may account for the decrease (26). NAA cannot be restored to normal levels because the neurons cannot regenerate (27).…”

Section: Discussionmentioning

confidence: 99%

Incense use and respiratory tract carcinomas

Friborg

Yuan

Wang

et al. 2008

Cancer

View full text Add to dashboard Cite

BACKGROUND.Incense use is an integral part of daily life in large parts of Asia. The burning of incense is a powerful producer of particulate matter and the smoke contains a multitude of well‐characterized carcinogens. However, to the authors' knowledge, no convincing association has been reported between exposure to incense smoke and the development of cancer. Therefore, the relation between incense use and the risk of respiratory tract carcinomas was analyzed in a prospective cohort study.METHODS.Between 1993 and 1998, a population‐based cohort of 61,320 Singapore Chinese who were free of cancer and ages 45 to 74 years completed a comprehensive interview regarding living conditions and dietary and lifestyle factors. Through linkage to population‐based registries, the cohort was followed through 2005 and cancer occurrence determined. The relative risk for these cancers associated with incense use was estimated using a Cox proportional hazards model.RESULTS.A total of 325 upper respiratory tract (UPT) carcinomas and 821 lung carcinomas were observed during follow‐up. Incense use was associated with a significantly increased risk of UPT carcinomas other than nasopharyngeal, whereas no overall effect was observed on lung cancer. The duration and intensity of incense use were associated with an increased risk of squamous cell carcinomas in the entire respiratory tract (P for trend = .004), whereas there was no significant association noted between incense use and nonsquamous cell carcinomas. The relative risk of squamous cell carcinomas among long‐term incense users was 1.8 (95% confidence interval [95% CI], 1.2‐2.6; P = .004) in the entire respiratory tract.CONCLUSIONS.The results of the current study indicate that long‐term use of incense is associated with an increased risk of squamous cell carcinoma of the respiratory tract. Cancer 2008. © 2008 American Cancer Society.

show abstract

“…NAA synthesis was shut down and this may account for the decrease (26). NAA cannot be restored to normal levels because the neurons cannot regenerate (27).…”

Section: Discussionmentioning

confidence: 99%

Incense use and respiratory tract carcinomas

Friborg

Yuan

Wang

et al. 2008

Cancer

View full text Add to dashboard Cite

show abstract

“…It is also known that point mutations and deletions in mitochondrial DNA (mtDNA) increase cellular radiosensitivity (Prithivirajsingh et al, 2004). Unlike nuclear DNA, mtDNA lacks an efficient DNA repair mechanism and is more vulnerable to the accumulation of DNA damage (Prithivirajsingh et al, 2004;Wilding et al, 2006). High levels of mtDNA mutations in the skin could predispose cancer patients to radiation-induced skin problems.…”

Section: Discussionmentioning

confidence: 99%

Post-treatment skin reactions reported by cancer patients differ by race, not by treatment or expectations

et al. 2007

View full text Add to dashboard Cite

Cancer patients may experience skin problems while undergoing chemotherapy and radiation therapy. Frequency of skin reactions may be influenced by skin pigmentation and psychological factors. A Symptom Inventory completed by 656 cancer patients nationwide before and after chemotherapy, radiation therapy, or chemotherapy plus radiation therapy was analysed to determine if treatment type, race (Black vs White), and pretreatment expectations influenced post-treatment skin reactions. Subsequent analysis of a local Symptom Inventory completed weekly for 5 weeks by 308 patients receiving radiation therapy examined severity of reported skin reactions. Significantly more patients receiving radiation therapy had stronger expectations of skin problems (62%) than patients receiving chemotherapy (40%, P ¼ 0.001) or chemotherapy plus radiation therapy (45%, P ¼ 0.003). Overall, expectations did not correlate with patient reported post-treatment skin problems in white (r ¼ 0.014, P ¼ 0.781) or black (r ¼ 0.021, P ¼ 0.936) patients. Although no significant difference was found between black and white patients in their pretreatment expectations of skin problems (P ¼ 0.32), black patients (10 out of 18, 56%) reported more skin problems than white patients (90 out of 393, 23%, P ¼ 0.001). Similarly, the local study showed that significantly more black patients (1 out of 5, 20%) reported severe skin reactions at the treatment site than white patients (12 out of 161, 8%). A direct correlation was observed between severity of skin problems and pain at the treatment site (r ¼ 0.541, Po0.001). Total radiation exposure did not significantly correlate with the report of skin problems at the treatment site for white or black patients. Overall, black patients reported more severe post-treatment skin problems than white patients. Our results suggest that symptom management for post-treatment skin reactions in cancer patients receiving radiation treatment could differ depending on their racial background.

show abstract

“…The mtDNA was extracted from blood lymphocytes and sequenced with Beckman Coulter CEQ8000. No significant increase in mtDNA mutation was detected among the high dose radiation workers [7]. However, it is important to note that this study only examined somatic mutations, not the inheritance of germ line mutations.…”

Section: Introductionmentioning

confidence: 99%

The use of next generation sequencing technology to study the effect of radiation therapy on mitochondrial DNA mutation

Guo

Cai

Samuels

et al. 2012

Mutation Research/Genetic Toxicology and Environmental Mutagene

Self Cite

View full text Add to dashboard Cite

The human mitochondrial genome has an exclusively maternal mode of inheritance. Mitochondrial DNA (mtDNA) is particularly vulnerable to environmental insults due in part to an underdeveloped DNA repair system, limited to base excision and homologous recombination repair. Radiation exposure to the ovaries may cause mtDNA mutations in oocytes, which may in turn be transmitted to offspring. We hypothesized that the children of female cancer survivors who received radiation therapy may have an increased rate of mtDNA heteroplasmy mutations, which conceivably could increase their risk of developing cancer and other diseases. We evaluated 44 DNA blood samples from 17 Danish and 1 Finnish families (18 mothers and 26 children). All mothers had been treated for cancer as children and radiation doses to their ovaries were determined based on medical records and computational models. DNA samples were sequenced for the entire mitochondrial genome using the Illumina GAII system. Mother’s age at sample collection was positively correlated with mtDNA heteroplasmy mutations. There was evidence of heteroplasmy inheritance in that 9 of the 18 families had at least one child who inherited at least one heteroplasmy site from his or her mother. No significant difference in single nucleotide polymorphisms between mother and offspring, however, was observed. Radiation therapy dose to ovaries also was not significantly associated with the heteroplasmy mutation rate among mothers and children. No evidence was found that radiotherapy for pediatric cancer is associated with the mitochondrial genome mutation rate in female cancer survivors and their children.

show abstract

Mitochondrial DNA Mutations in Individuals Occupationally Exposed to Ionizing Radiation

Cited by 19 publications

References 37 publications

Incense use and respiratory tract carcinomas

Incense use and respiratory tract carcinomas

Post-treatment skin reactions reported by cancer patients differ by race, not by treatment or expectations

The use of next generation sequencing technology to study the effect of radiation therapy on mitochondrial DNA mutation

Contact Info

Product

Resources

About