Mitochondrial DNA haplogroups and ageing mechanisms in osteoarthritis

Valdes, Ana M.; Goldring, Mary B.

doi:10.1136/annrheumdis-2016-210783

Cited by 13 publications

(13 citation statements)

References 25 publications

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“…The mitochondrion is a vital intracellular organelle responsible for energy production and intracellular signaling in the eukaryotic system. Mitochondrial dysfunction often accompanies and contributes to human disease development [27,28]. During the process of oxidative phosphorylation, mitochondria utilize oxygen to generate ATP from organic molecules, but also produce ROS in the same process which affects various signaling processes within the cell.…”

Section: Reactive Oxygen Species (Ros)mentioning

confidence: 99%

Reactive Oxygen Species in Osteoclast Differentiation and Possible Pharmaceutical Targets of ROS-Mediated Osteoclast Diseases

Agidigbi

Kim

2019

IJMS

311

230

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Reactive oxygen species (ROS) and free radicals are essential for transmission of cell signals and other physiological functions. However, excessive amounts of ROS can cause cellular imbalance in reduction–oxidation reactions and disrupt normal biological functions, leading to oxidative stress, a condition known to be responsible for the development of several diseases. The biphasic role of ROS in cellular functions has been a target of pharmacological research. Osteoclasts are derived from hematopoietic progenitors in the bone and are essential for skeletal growth and remodeling, for the maintenance of bone architecture throughout lifespan, and for calcium metabolism during bone homeostasis. ROS, including superoxide ion (O2−) and hydrogen peroxide (H2O2), are important components that regulate the differentiation of osteoclasts. Under normal physiological conditions, ROS produced by osteoclasts stimulate and facilitate resorption of bone tissue. Thus, elucidating the effects of ROS during osteoclast differentiation is important when studying diseases associated with bone resorption such as osteoporosis. This review examines the effect of ROS on osteoclast differentiation and the efficacy of novel chemical compounds with therapeutic potential for osteoclast related diseases.

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Section: Reactive Oxygen Species (Ros)mentioning

confidence: 99%

Reactive Oxygen Species in Osteoclast Differentiation and Possible Pharmaceutical Targets of ROS-Mediated Osteoclast Diseases

Agidigbi

Kim

2019

IJMS

311

230

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“…Recently, it has been shown that the accumulation of ROS in chondrocytes can lead to mtDNA mutations. Researchers have even identified the specific mtDNA haplogroups J and T that have been associated with variations in the prevalence and progression of cartilage loss in some European populations . In particular, the J haplotype has been linked to lower serum levels of markers of collagen type‐II degradation and of MMPs and higher ATP levels in the Spanish population, while the T haplotype correlates with lower disease risk in a small UK cohort …”

Section: Role Of Inflammation and Oxidative Stress In Osteoarthritismentioning

confidence: 99%

Oxidative stress and chronic inflammation in osteoarthritis: can NRF2 counteract these partners in crime?

Marchev

Dimitrova

Burns

et al. 2017

Annals of the New York Academy of Sciences

175

135

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“…Mitochondrial dysfunction is suggested to be the cause of many other age-related degenerative disorders such as Alzheimer. Investigations by Fern andez-Moreno et al, reveled the presence of a J haploid in OA patients 51,52 This haploied is associated with increased risk of OA due to an increase in ROS and oxidative stress. The J haploied slowes the inflamatory cellular self healing process, and induces cellular appopltosis through wnt pathway.…”

Section: Genes Targeted For Gene Therapymentioning

confidence: 99%

Nutritional, metabolic and genetic considerations to optimise regenerative medicine outcome for knee osteoarthritis

Hafsi

McKay

et al. 2019

Journal of Clinical Orthopaedics and Trauma

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Knee osteoarthritis (KOA) is a multifactorial degenerative disorder of joints, affecting the world's population over the age of 65 and with a higher prevalence in females. KOA is responsible for many age associated joint problems such as stiffness and pain. Conventional methods for managing KOA such as nonsteroidal anti-inflammatory drugs (NSAID) may not improve pain or alter the disease progression and may have adverse side effects. Non-pharmacological management of OA is fundamental to management of functional limitations and provides effective symptom relief but has not shown that disease progression can be altered. Regenerative medicine is a relatively new approach which aims to induce cellular regeneration and promote self-healing through minimally invasive methods. The use of regenerative medicine slowed the progression of KOA and revealed significant improvements, yet further investigations are required to optimize the outcomes. Nutritional and metabolic aspects such as supplementations, vitamins and minerals were proven to have an impact on the progression of KOA. Genetic variations are rapidly inspected to identify any potential influence of these variations in the predisposition and diagnosis of KOA. Further supporting evidence suggests the potential influence of metabolic, nutritional and genetic aspects in optimizing the outcomes of regenerative medicine in the management of KOA.

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Mitochondrial DNA haplogroups and ageing mechanisms in osteoarthritis

Cited by 13 publications

References 25 publications

Reactive Oxygen Species in Osteoclast Differentiation and Possible Pharmaceutical Targets of ROS-Mediated Osteoclast Diseases

Reactive Oxygen Species in Osteoclast Differentiation and Possible Pharmaceutical Targets of ROS-Mediated Osteoclast Diseases

Oxidative stress and chronic inflammation in osteoarthritis: can NRF2 counteract these partners in crime?

Nutritional, metabolic and genetic considerations to optimise regenerative medicine outcome for knee osteoarthritis

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